Chin-Hsing Annie Lin, Ph.D.
Ph.D.; University of Alabama at Birmingham
M.S.; University of Alabama at Birmingham
B.S.; Providence University, Taiwan
Dr. Lin’s research is focused on the stem cell and cancer biology. Ongoing studies in the lab related to stem cell biology include: 1) understanding how stem cells in adult brain migrate and homing to their final destination to generate functional neurons; 2) how we can apply stem cells to the regenerative medicine for treating stroke, trauma, spinal cord injury, and neurological disorders; and 3) what extent stem progenitor cells become cancer-initiating cells. The lab's work has potential implications for basic stem cell biology as well as translational significance for treatment and prevention of diseases.
Approaches used in the lab include animal models, genome editing, live and large-scale imaging, and high throughput genome-wide analyses. To analyze discrete populations of cells in the brain regions with spatial complexity, the lab purifies in vivo neural stem progenitor cells (NSPCs) for cutting-edge genome-wide assays (i.e. ChIPSeq; RNA-Seq; quantitative proteome) to glean epigenetic landscape as well as differential expression of proteins and transcripts at different stages of cell fate as they exist in vivo. The lab has mapped out the epigenetic landscape and delineated gene expression between normal and disease conditions; using conditional rodent models, they are currently assessing in vivo phenotypes.
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