Faculty


 

Hyoung-gon Lee
Hyoung-gon Lee, Ph.D.
Associate Professor
John H. Doran, M.D., F.A.C.P., Distinguished Professorship in Peripheral Neuropathy

Phone: (210) 458-5088
Email: hyoung-gon.lee@utsa.edu

Areas of Specialization

» Alzheimer disease
» Neurobiology
» Neurodegeneration


Brain Health Consortium
UTSA Neurosciences Institute

Education

Ph.D.; Case Western Reserve University

Research Interests

Dr. Lee’s research is focused mainly on the understanding of the pathological mechanism(s) underlying the selective neurodegeneration in Alzheimer disease (AD) and other neurodegenerative diseases. Multiple molecular mechanisms identified from previous research in the lab which would lead to the development of the effective therapy. Among these identified mechanisms, ongoing research in the lab is focused on following topics.

Cell cycle re-entry in neurodegeneration

Aberrant cell cycle activation in neurons is now emerging as a key pathogenic mechanism in many neurodegenerative diseases, including AD. The lab has recently developed the transgenic mouse models to study the role of aberrant cell cycle re-entry in neurodegeneration and, with these animal models, the lab focuses on elucidating molecular and cellular mechanism how cell cycle re-entry causes neurodegeneration.

Insulin signaling in AD

Defects in glucose metabolism and insulin signaling in the AD brain have also been suggested as an underlying cause of neurodegeneration in AD although its causal mechanism is elusive. Dr. Lee’s lab has been studying potential mechanisms causing dysregulation of neuronal insulin signaling and its pathological effect on AD. Several molecular targets have been identified in the lab and the lab is actively pursuing to reveal the molecular/cellular mechanism and its pathological role in AD.

Training Opportunities

Aberrant cell cycle activation in neurons is now emerging as a key pathogenic mechanism in many neurodegenerative diseases, including AD. Dr. Lee's lab has recently developed the transgenic mice models to study the role of aberrant cell cycle re-entry in neurodegeneration and current research focuses on how cell cycle re-entry causes neurodegeneration in these animal models.

Defects in glucose metabolism and insulin signaling in AD brain tissues have been suggested as an underlying cause of neurodegeneration in AD although its causal mechanism is elusive. Dr. Lee's lab has been studying potential mechanisms causing dysregulation of insulin signaling in neurons and its pathological effect on AD.

Publications

Click here for a list of publications.