Hyoung-gon Lee, Ph.D.
John H. Doran, M.D., F.A.C.P., Distinguished Professorship in Peripheral Neuropathy
Phone: (210) 458-5088
Areas of Specialization
» Alzheimer disease
Ph.D.; Case Western Reserve University
Dr. Lee’s research is focused mainly on the understanding of the pathological mechanism(s) underlying the selective neurodegeneration in Alzheimer disease (AD) and other neurodegenerative diseases. Multiple molecular mechanisms identified from previous research in the lab which would lead to the development of the effective therapy. Among these identified mechanisms, ongoing research in the lab is focused on following topics.
Cell cycle re-entry in neurodegeneration
Aberrant cell cycle activation in neurons is now emerging as a key pathogenic mechanism in many neurodegenerative diseases including AD. The lab has recently developed the transgenic mouse models to study the role of aberrant cell cycle re-entry in neurodegeneration and, with theses animal models, the lab focuses on elucidating molecular and cellular mechanism how cell cycle re-entry causes neurodegeneration.
Insulin signaling in AD
Defects in glucose metabolism and insulin signaling in AD brain have also been suggested as an underlying cause of neurodegeneration in AD although its causal mechanism is elusive. Dr. Lee’s lab has been studied potential mechanisms causing dysregulation of neuronal insulin signaling and its pathological effect on AD. Several molecular targets have been identified in the lab and the lab is actively pursuing to reveal the molecular/cellular mechanism and its pathological role in AD.
Click here for a list of publications.