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Faculty

Mark Eppinger, Ph.D.

Assistant Professor

Phone: (210) 458-6276
Email: mark.eppinger@utsa.edu

Lab website:
http://stceid.utsa.edu/lab-Eppinger/

Areas of Specialization

» Bioinformatics
» Infectious diseases
» Microbial genomics


South Texas Center for Emerging Infectious Diseases


Education

Ph.D. in Microbial Genetics; Max-Planck Institute for Developmental Biology, University of Tuebingen, Germany
B.S. in Biology; University of Tuebingen, Germany

 

Research Interests

 

The focus of Dr. Eppinger’s research is on the application of microbial genomics to address fundamental questions in emerging infectious diseases research. His current interests are directed towards large-scale sequencing and phylogenomic studies investigating major public health threats, such as the causative agents of plague (Yersinia pestis) and cholera (Vibrio cholera) and the dominant cause of food-borne disease in North America, Escherichia coli O157:H7. Experimental approaches include:

  1. Microbial Genome Sequencing – the gathering of additional sequence data as prerequisite to capture the genome architecture and genomic diversity in environmental or clinical settings
  2. Phylogenomics – the development of bioinformatics tools to survey the plasticity within pathogen populations and elucidate the ancestry of microbial species
  3. Microbial Diversity – the discovery of subtle yet important genetic variations in gene content and activity
  4. Pathogenicity – the study of virulence determinants and dynamic host-pathogen interactions

Data from this research provides crucial insights into the make-up of bacterial pathogens and how genomic variants relate to differences in evolutionary and ecological niches that underlie human transmissibility, infectivity and disease outcome. Most importantly, this research can help to initiate therapeutic and diagnostic countermeasures in an attempt to decrease human morbidity rates.

 

Publications

Click here for a list of publications.

 

Book Chapters

S.M. Shah, T.H. Hazen, D.A. Rasko, M. Eppinger (2015): EHEC genomics: Past, present and future in "Enterohemorrhagic Escherichia coli and Other Shiga Toxin-Producing E. coli," in V. Sperandio, C.J. Hovde-Bohach (Editors). ASM Press (Publisher); 1st edition (May 1st, 2015) (ISBN-10: 1555818781, ISBN-13: 978-1555818784)

M. Eppinger, J. Ravel and L.E. Lindler (2012): Pathogenic Yersinia, in X.Yan, V.K. Juneja, P.M. Fratamico, J.L. Smith, (Editors): Omics, Microbial Modeling and Technologies for Food-borne Pathogens. DEStech Publications, Inc. (Publisher); 1st edition (January 10th, 2012) (ISBN-10: 1605950475ISBN-13: 978-1605950471)