Department of Chemistry Faculty
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Hyunsoo Han

Hyunsoo Han

  • Ph.D.: 1991, Princeton University
  • M.S.: 1983, Seoul National university
  • B.S.: 1981, Kyung-Pook National University

Research Interests

  • Organic Synthesis: methodology development for the asymmetric synthesis of the polyhydroxylated/polyaminated bioactive compounds
  • Asymmetric catalysis: design, synthesis, and application of a new class of ultra-nucleophilic catalysts
  • Polymer and combinatorial chemistry: polymer-based desymmetrization, parallel kinetic resolution, macrocylization, catenane synthesis, and macrocyclic chemical library synthesis


Positions Available


If the information above or in any of the related sites interests you, please feel free to contact me.

Opportunities for financial support are available on a competitive basis.

Selected Publications
  1. Singh, O. V.; Han, H. Iridium(I)-catalyzed regio- and enantioselective allylic amidation. Accepted for publication in Tetrahedron Letters.
  2. Singh, O. V.; Han, H. Iridium(I)-catalyzed regio- and enantioselective decarboxylative allylic amidation of substituted allyl benzyl imidodicarbonates. Journal of American Chemical Society 2007, 129, 774-775.
  3. Singh, S.; Das, G.; Singh, O. V.; Han, H. Development of more potent 4-dimethylaminopyridine analogues. Organic. Letters 2007, 9, 401-404.
  4. Singh, S.; Das, G.; Singh, O. V.; Han, H. Conformationally restricted 4-dimethylaminopyridine (DMAP) analogs: Synthesis and evaluation of catalytic effectiveness. Tetrahedron Letters 2007, 48, 1983-1986.
  5. Singh, O. V.; Han, H. Stereoselective synthesis of trans-olefins by the copper-mediated SN2' reaction of vinyl oxazines with Grignard reagents. Asymmetric synthesis of D-threo-sphingosines. Tetrahedron Letters 2007, 48, 2345-2348.
  6. Chikkanna, D.; Singh, O. V.; Kong, S. B.; Han, H. A General Asymmetric Route for the Synthesis of the Alexine and Australine Family of Pyrrolizidine Alkaloids. The First Asymmetric Synthesis of 1,2-diepi-Alexine and 1,2,7-triepi-Australine. Tetrahedron Letters 2005, 46, 8865-8868.
  7. Singh, O. V.; Han, H. Tandem Overman Rearrangement and Intramolecular Amidomercuration Reactions. Stereocontrolled Synthesis of cis- and trans-2,6-Dialkylpiperidines. Organic Letters 2004, 6, 3067-3070.
  8. Singh, O. V.; Kampf, D. J.; Han, H. Oxazine Formation by MsCl/Et3N as a Convenient Tool for the Stereochemical Interconversion of the Hydroxyl Group in N-Acetyl 1,3-aminoalcohols. Asymmetric Synthesis of N-Acetyl L-xylo- and L-arabino-phytosphingosines. Tetrahedron Letters 2004, 45, 7239-7242.
  9. Chikkanna, D.; Han, H. Hg(II) Reagent-controlled Stereoselective Synthesis of 2,5-cis- and 2,5-trans-Polyhydroxylated Pyrrolidines. Synlett 2004, 2311-2314.
  10. Singh, S.; Han, H. Stereodivergent Total Asymmetric Synthesis of Polyhydroxylated Pyrrolidines via Tandem Allylic Epoxidation and Intramolecular Cyclization Reactions. Tetrahedron Letters 2004, 45, 6349-6352.
  11. Singh, O. V.; Han, H. A General Methodology for the Asymmetric Synthesis of 1-Deoxyiminosugars. em>Tetrahedron Letters 2003, 44, 2387-2391.
  12. Han, H.; Yang, H. A Complete Asymmetric Synthesis of Polyhydroxypiperidines. Tetrahedron Letters 2003, 44, 1567-1569.
  13. Singh, S.; Chikkanna, D.; Singh, O.; Han, H. A Highly Efficient and Stereoselective Synthesis of Polyhydroxylated Pyrrolidines via Regioselective Asymmetric Aminohydroxylation (RAA) and Intramolecular Amidomercuration Reactions. Synlett 2003, 1279-1282.
  14. Singh, O. V.; Han, H. A Concise and General Methodology for the Complete Asymmetric Synthesis of the Orthogonally Protected 2-Amino-1,3,4-butanetriols (ABRs). Tetrahedron Letters 2003, 44, 5289-5292.
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