Department of Chemistry Faculty
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Candace M. Coyle

Candace M. Coyle

  • Postdoctoral Research Associate: 2001, Princeton University
  • Ph. D., Physical Chemistry: 1999, West Virginia University
  • B.S., Chemistry: 1994, Virginia Polytechnic Institute and State University

Research Interests

  • Biophysical Spectroscopy: Applications of Surface enhanced Raman scattering (SERS) spectroscopy to elucidate the structural and mechanistic details of the interaction of nucleic bases, DNA and RNA with copper in carcinogenic tissues
  • Biosensors: Optical detection technologies applied to Homeland Security to serves as a basic optical tool that can target both chemical and biological agents of interest Specifically, stand-off detection of the linkage of agent-specific binding proteins to modified gold nanoparticles using SERS
  • Environmental Chemistry: Investigating the nature of manganese oxide degradation of sulfonylurea herbicides in the environment using resonance Raman (RR) and ATR-IR spectroscopies


Positions Available


If the information above or in any of the related sites interests you, please feel free to contact me.

Opportunities for financial support are available on a competitive basis.

Selected Publications
  1. Coyle, C. M.; Vogel, K. M.; Rush III, T. S.; Kozlowski, P.; Dou, Y.; Ikeda-Saito, M.; Spiro T.G.; Olson, J.S. FeNO Structure in Distal Pocket Mutants of Myoglobin from Resonance Raman Spectroscopy. Biochemistry, 2003, 42, 4896-4903.
  2. Coyle, C. M.; Puranik, M.; Youn, H.; Nielsen, S. B.; Williams, R. D.; Roberts, G. P.; Spiro, T. G. Activation Mechanism of the CO Sensor CooA: Mutational and Resonance Raman Spectroscopic Studies. J. Biol. Chem., 2003, 278, 35384-35393.
  3. Coyle, C. M.; Chumanov, G.; Jagodzinski, P. W. Surface-Enhanced Raman Spectra of the Reduction Product of 4-Cyanopyridine on Copper Colloids. J. Raman Spectrosc., 1998, 29, 757-762.
  4. Coyle, C. M.; Chumanov, G.; Jagodzinski, P. W. Transition Metal Assisted Borohydride Reduction of Aromatic and Aliphatic Nitriles on Copper Colloids, in preparation.
  5. Tian, F.; Wang, M.; Coyle, C. M. Copper-Nucleic Acid Binding Dynamics Interrogated by SERS Spectroscopy, in preparation.
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