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Harry Wellington Jarrett III

• Postdoctoral Fellow: 1977-1980, University of California at San Diego
• Postdoctoral Fellow: 1976-1977, The Mayo Clinic
• Ph.D., Biochemistry: 1976, University of North Carolina, Chapel Hill
• B.S., Biology: 1972, University of South Carolina

Research Interests

• Muscular Dystrophy and Signal transduction: Dystrophin, the protein product of the Duchenne muscular dystrophy gene locus, is linked to a signal transduction pathway,
  which links laminin-a-dystroglycan-ß-dystroglycan-dystrophin-syntrophin-Grb2-Sos1-
  Rac1-PAK1-MKK4/7-JNK, causing c-jun phosphorylation and activation.

• Transcription factor purification: We developed oligonucleotide trapping, a method for purifying transcription factors to near homogeneity in a single step. Current experiments involve promoter trapping, a method which interfaces DNA-HPLC with proteomic techniques (MALDI-TOF and ESE-ion trap) to characterize the transcription complex of the c-jun promoter.

Teaching Activities

• Biochemistry

Positions Available