UTSA COS Summer Research Experience for 2013
Mucosal Defenses Against Acinetobacter Baumannii
Acinetobacter baumannii has emerged as an important nosocomial pathogen observed in injured military service personnel from the Middle East. Many multi-drug resistant strains of A. baumannii have been indentified which create additional therapeutic challenges for effective management of this infection. There is evidence to suggest that gastrointestinal colonization of A. baumannii in humans precedes the onset of other clinical conditions such as septicemia, pneumonia and wound sepsis, with little known about the interaction of this pathogen with the gastrointestinal (GI) tract. Dr. Arulanandam's lab has developed an oral-gastrointestinal (GI) challenge model with A. baumannii to examine the contribution of mucosal immune defenses against gastrointestinal colonization by this pathogen and the subsequent systemic manifestation of this infection.