(Dec. 15, 2009)--Led by Joe L. Martinez Jr., UTSA Ewing Halsell Distinguished Chair in Biology, a team of UTSA researchers found that radiation therapy can prevent the brain from forming some types of fearful memories. Further research may lead to treatments for post-traumatic stress disorder and Alzheimer's disease.
Radiation therapy reduces the number of new granule cells in the hippocampus, the part of the brain responsible for autobiographical memory. Cranial irradiation, or radiation of the skull, is commonly used as a treatment to prevent cancer from spreading to the brain. However, long-term cognitive impairments, such as the inability to learn or remember new tasks, often occur as a result of the procedure.
The researchers tested the ability of rats to form three types of fear memories: delay fear memories, context fear memories and trace fear memories. Delay fear memories form when a fearful situation occurs simultaneously with another event. Context fear memories form when a fearful situation follows another event and both take place in the same physical space. Trace fear memories form when an event and a fearful situation are separated by a pause.
Combining biological and psychological approaches in the laboratory, the researchers observed the behavior of rats not producing new granule cells in their brains. The researchers observed that the rats were able to form delay and fear memories but were unable to form trace fear memories. The findings led them to believe that new granule cells are not required in the hippocampus of the brain to form delay and context fear memories but are required for the formation of trace fear memories.
"This research has broad applications including treatments for post-traumatic stress disorder and Alzheimer's disease," said Martinez. "If we can pinpoint the neurons in the hippocampus that are responsible for storing trace fear memories, we may be able to selectively erase negative memories by decreasing the number of new granule cells in the brain. Or, we may be able to prevent memory loss by preventing the death of new granule cells. Such therapies could definitely enhance an individual's life, but we have a long way to go before we put the theory into practice."
The UTSA community welcomes students to their on-campus home! Laurel Village, Chaparral Village and Alvarez Hall are home for 2,300 students during the academic year, and Move-In event kicks off the start of Roadrunner Days.
Laurel Village, Chaparral Village, Alvarez Hall, Main Campus
This is a terrific opportunity for incoming transfer students to network with staff that serve our veteran, non-traditional, and transferring students, as well as meet transfer peer mentors who can help answer questions about UTSA.
Main Building ground floor lobby, Main Campus
After a day full of moving and getting settled into their new UTSA home, students and their families can have some refreshments and snacks at the Welcome Back Reception. The event tops off with the premiere performance of the Spirit of San Antonio, UTSA's Marching Band.
University Center Paseo, Main Campus
Can you survive the library wilderness? As a part of Roadrunner Days, UTSA Libraries is hosting a mobile adventure for you to play and find out more about the library!
John Peace Library, 2nd floor, Main Campus
Come meet your UTSA Volleyball Team as they gear up for the 2017 season! The game begins at 5 p.m. then the team will hold an autograph and photo session after the game.
Convocation Center, Main Campus
This engaging discussion pulls back the covers on hooking up, clarifying when it’s actually sexual violence and how bystanders can protect potential victims from predators.
University Center, Retama Auditorium (UC 2.02.02), Main Campus
Late Night at the Rec is an awesome UTSA tradition that transforms a standard information session into an exciting night of fun. At this annual event, you’ll be able to learn about our facilities, recreation programs, and wellness services offered at Main and Downtown Campuses.
Recreation and Wellness Center, Main Campus
The UTSA community is invited to the Community Networking events hosted by the Student Center for Community Engagement and Inclusion during Roadrunner Days. Various opportunities will be available that will focus on our diverse population.
H-E-B University Center Ballrooms (HUC 1.104 and HUC 1.106), Main Campus
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
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