Sunday, August 02, 2015

UTSA biology research could lead to treatments for PTSD and Alzheimer's

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(Dec. 15, 2009)--Led by Joe L. Martinez Jr., UTSA Ewing Halsell Distinguished Chair in Biology, a team of UTSA researchers found that radiation therapy can prevent the brain from forming some types of fearful memories. Further research may lead to treatments for post-traumatic stress disorder and Alzheimer's disease.

Radiation therapy reduces the number of new granule cells in the hippocampus, the part of the brain responsible for autobiographical memory. Cranial irradiation, or radiation of the skull, is commonly used as a treatment to prevent cancer from spreading to the brain. However, long-term cognitive impairments, such as the inability to learn or remember new tasks, often occur as a result of the procedure.

The researchers tested the ability of rats to form three types of fear memories: delay fear memories, context fear memories and trace fear memories. Delay fear memories form when a fearful situation occurs simultaneously with another event. Context fear memories form when a fearful situation follows another event and both take place in the same physical space. Trace fear memories form when an event and a fearful situation are separated by a pause.

Combining biological and psychological approaches in the laboratory, the researchers observed the behavior of rats not producing new granule cells in their brains. The researchers observed that the rats were able to form delay and fear memories but were unable to form trace fear memories. The findings led them to believe that new granule cells are not required in the hippocampus of the brain to form delay and context fear memories but are required for the formation of trace fear memories.

"This research has broad applications including treatments for post-traumatic stress disorder and Alzheimer's disease," said Martinez. "If we can pinpoint the neurons in the hippocampus that are responsible for storing trace fear memories, we may be able to selectively erase negative memories by decreasing the number of new granule cells in the brain. Or, we may be able to prevent memory loss by preventing the death of new granule cells. Such therapies could definitely enhance an individual's life, but we have a long way to go before we put the theory into practice."

 

 

Did You Know?

UTSA researcher is a star behind the cloud

A revolution in cloud computing is underway, and Ravi Sandhu believes it will be much bigger than the PC and Internet revolutions that have already changed the way we live. Sandhu, director of the UTSA Institute for Cyber Security, says UTSA is taking a leadership role in tackling three fundamental cloud technology problems: how to build and operate the cloud, how to use it profitably for diverse applications and how to keep it secure.

Sandhu, the Lutcher Brown Distinguished Chair in Cyber Security in the College of Sciences, and Ram Krishnan, assistant professor of electrical engineering in the UTSA College of Engineering, are funded by a $500,000 grant from the National Science Foundation to improve cloud security.

Did you know? Sandhu, a world-renowned cybersecurity expert, holds 30 patents, has authored more than 250 papers and been cited more than 30,000 times.

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Events
Aug. 1, 9 p.m.

"Inside Peace" documentary screening

This documentary, presented by the San Antonio Film Festival, documents the experience of re-entry after incarceration. The film features Michael Gilbert, associate professor in the department of criminal justice and director of the Office of Community and Restorative Justice program at UTSA.
Tobin Center for the Performing Arts, 100 Auditorium Circle

Aug. 4, 6 - 8 p.m.

Free Teacher Tuesday: Los Tejanos Workshop

Discover resources and strategies for teaching Tejano history and culture and get a special educator's tour of the new long-term exhibit, Los Tejanos.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 6, 5 - 7 p,m,; 9 a.m. - 3:30 p.m.

6th Annual Texas Higher Education Symposium

This annual symposium is an opportunity to discuss Texas higher education issues and trends with Texas higher education scholars, state and local government officials, students, and campus and local community members.
Downtown Campus

Aug. 9, 12 - 5 p.m.

Vaquerocation 2015

This cowboy-themed programming, offered in conjunction with Our Kids Magazine's Kidcation Week, gives families the opportunity to visit with cowboy docents, enjoy readings and visit activity tables.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 17, 11:30 p.m.

Midnight Light

Join President Ricardo Romo, The Spirit of San Antonio Marching Band, students, faculty and staff to light the monument at the Main Campus entrance at the stroke of midnight.
John Peace Boulevard Entrance, Main Campus

Aug. 18, 11 a.m. - 1 p.m.

President's BBQ on the Plaza

Join university President Ricardo Romo on the Bill Miller Plaza for his annual free BBQ lunch.
Bill Miller Plaza, Downtown Campus

Aug. 18, 5:30 p.m. - 7:30 p.m.

President's BBQ on the Lawn

Join university President Ricardo Romo on the Convocation Center lawn for his annual free BBQ lunch.
Convocation Center East Lawn, Main Campus

Aug. 22, 6 p.m.

UTSA Alumni Gala

The UTSA Alumni Association hosts this annual gala honoring the Alumna of the Year, Alumnus of the Year and the Alumnus of the Year Lifetime Achievement award winners.
Hyatt Regency Hill Country Resort & Spa, 9800 Hyatt Resort Dr.


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