(May 14, 2010)--Researchers at the UTSA Neurosciences Institute are one step closer to understanding the physiology of dopaminergic neurons, the neurons in the brain that generally produce dopamine but die during Parkinson's disease.
Because dopaminergic neurons are the neurons that die during Parkinson's disease, and they also are the neurons affected when a drug user takes psycho-stimulants such as cocaine and amphetamine, the research has profound implications for public health.
Typically, dopaminergic neurons fire fast bursts of electrical activity. Scientists widely agree a protein called the NMDA receptor in the neuron's outer membrane has something to do with the ability to fire such fast bursts.
UTSA Assistant Professor Carlos Paladini and Professor Charles Wilson in the Department of Biology set out to learn how NMDA receptors cause bursts of firing in the brain's dopaminergic neurons. In a series of studies, the researchers observed that the NMDA receptor is highly sensitive to voltages. When the outer membrane's voltage is more positive, the NMDA receptor channel opens and leads to a single spike of electrical activity. When the outer membrane's voltage is more negative, the NMDA receptor channel closes and allows the neuron to recover from the previous spike of electrical activity.
Because the dopaminergic neuron's voltages quickly alternate between positive and negative, the result is NMDA receptors also quickly alternate between open and closed states. Voltage cues cause the NMDA receptors to oscillate rapidly several times between a spike of electrical activity one moment and silence the next, allowing dopaminergic neurons to fire a rapid burst of spikes: one spike with each NMDA receptor oscillation.
"For some reason, dopaminergic neurons are vulnerable in Parkinson's disease," said Paladini. "This study helps us better understand the physiology underlying their vulnerability."
Organizations participating in the golf cart parade will be creatively decorating their carts in the 2017 UTSA Homecoming theme "Spirit, Tradition, and Pride".
University Center Lawn, Main Campus
As he wrote about in his book, Kill It To Save It: An Autopsy of Capitalism's Triumph Over Democracy, Corey Dolgon will speak about what made Donald Trump the preferred choice for many voters and shows how policy is crafted, marketed and sold or rejected.
Buena Vista Street Building, Aula Canaria Lecture Hall (BVB 1.328), Downtown Campus
The UTSA African American Studies Program is proud to present Dr. Rupert Evans, a Harvard Macy Scholar and the immediate past President of the Institute for Diversity in Health Management.
Main Building (MB 0.208), Main Campus
President Taylor Eighmy is inviting all UTSA faculty and staff to "Tacos With Taylor." Take the opportunity to introduce yourself to the President at any one of these casual meet and greets.
Frio Street Building, Food Court Commons Area, Downtown Campus
Celebrate 40 years of BestFest, an annual event hosted by Roadrunner Productions as a part of UTSA Homecoming festivities. The event will feature a carnival, food and drink booths, a golf cart parade, firework and live music from Anthem.
Brackenridge Lot 1, Main Campus
Celebrate homecoming as the Roadrunners take on Rice. Come early for the Spirit Walk, tailgating, games, music and food. Stick around for a halftime show with SOSA and the crowning of Mr. and Ms. UTSA.
Alamodome, 100 Montana St., Downtown San Antonio
The Leadership Storytelling Homecoming Brunch brings together UTSA alumni and students to share a delicious meal as well as a roundtable conversation about how experiences in college carry us forward on unique leadership journeys.
University Center, Denman Room (UC 2.01.28), Main Campus
The conference is dedicated to sharing recent knowledge and experiences gained in the area of Big Data by researchers in academia, industry and the government sectors within the areas of business, national security, infrastructure, healthcare and visualization. The conference fee is $45 and includes breakfast, lunch & parking. Free for students and non-academic government employees. Register here: https://www.regonline.com/UTSAdataconference2017.
H-E-B University Center Ballroom (HUC 1.104), Main Campus
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