Saturday, August 01, 2015

UTSA brain research offers lead in treatment of Parkinson's disease

brain neurons

Dopaminergic neurons in the brain

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(May 14, 2010)--Researchers at the UTSA Neurosciences Institute are one step closer to understanding the physiology of dopaminergic neurons, the neurons in the brain that generally produce dopamine but die during Parkinson's disease.

Because dopaminergic neurons are the neurons that die during Parkinson's disease, and they also are the neurons affected when a drug user takes psycho-stimulants such as cocaine and amphetamine, the research has profound implications for public health.

Typically, dopaminergic neurons fire fast bursts of electrical activity. Scientists widely agree a protein called the NMDA receptor in the neuron's outer membrane has something to do with the ability to fire such fast bursts.

UTSA Assistant Professor Carlos Paladini and Professor Charles Wilson in the Department of Biology set out to learn how NMDA receptors cause bursts of firing in the brain's dopaminergic neurons. In a series of studies, the researchers observed that the NMDA receptor is highly sensitive to voltages. When the outer membrane's voltage is more positive, the NMDA receptor channel opens and leads to a single spike of electrical activity. When the outer membrane's voltage is more negative, the NMDA receptor channel closes and allows the neuron to recover from the previous spike of electrical activity.

Because the dopaminergic neuron's voltages quickly alternate between positive and negative, the result is NMDA receptors also quickly alternate between open and closed states. Voltage cues cause the NMDA receptors to oscillate rapidly several times between a spike of electrical activity one moment and silence the next, allowing dopaminergic neurons to fire a rapid burst of spikes: one spike with each NMDA receptor oscillation.

"For some reason, dopaminergic neurons are vulnerable in Parkinson's disease," said Paladini. "This study helps us better understand the physiology underlying their vulnerability."

 

 

Did You Know?

UTSA researcher is a star behind the cloud

A revolution in cloud computing is underway, and Ravi Sandhu believes it will be much bigger than the PC and Internet revolutions that have already changed the way we live. Sandhu, director of the UTSA Institute for Cyber Security, says UTSA is taking a leadership role in tackling three fundamental cloud technology problems: how to build and operate the cloud, how to use it profitably for diverse applications and how to keep it secure.

Sandhu, the Lutcher Brown Distinguished Chair in Cyber Security in the College of Sciences, and Ram Krishnan, assistant professor of electrical engineering in the UTSA College of Engineering, are funded by a $500,000 grant from the National Science Foundation to improve cloud security.

Did you know? Sandhu, a world-renowned cybersecurity expert, holds 30 patents, has authored more than 250 papers and been cited more than 30,000 times.

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Events
Aug. 1, 9 p.m.

"Inside Peace" documentary screening

This documentary, presented by the San Antonio Film Festival, documents the experience of re-entry after incarceration. The film features Michael Gilbert, associate professor in the department of criminal justice and director of the Office of Community and Restorative Justice program at UTSA.
Tobin Center for the Performing Arts, 100 Auditorium Circle

Aug. 4, 6 - 8 p.m.

Free Teacher Tuesday: Los Tejanos Workshop

Discover resources and strategies for teaching Tejano history and culture and get a special educator's tour of the new long-term exhibit, Los Tejanos.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 6, 5 - 7 p,m,; 9 a.m. - 3:30 p.m.

6th Annual Texas Higher Education Symposium

This annual symposium is an opportunity to discuss Texas higher education issues and trends with Texas higher education scholars, state and local government officials, students, and campus and local community members.
Downtown Campus

Aug. 9, 12 - 5 p.m.

Vaquerocation 2015

This cowboy-themed programming, offered in conjunction with Our Kids Magazine's Kidcation Week, gives families the opportunity to visit with cowboy docents, enjoy readings and visit activity tables.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 17, 11:30 p.m.

Midnight Light

Join President Ricardo Romo, The Spirit of San Antonio Marching Band, students, faculty and staff to light the monument at the Main Campus entrance at the stroke of midnight.
John Peace Boulevard Entrance, Main Campus

Aug. 18, 11 a.m. - 1 p.m.

President's BBQ on the Plaza

Join university President Ricardo Romo on the Bill Miller Plaza for his annual free BBQ lunch.
Bill Miller Plaza, Downtown Campus

Aug. 18, 5:30 p.m. - 7:30 p.m.

President's BBQ on the Lawn

Join university President Ricardo Romo on the Convocation Center lawn for his annual free BBQ lunch.
Convocation Center East Lawn, Main Campus

Aug. 22, 6 p.m.

UTSA Alumni Gala

The UTSA Alumni Association hosts this annual gala honoring the Alumna of the Year, Alumnus of the Year and the Alumnus of the Year Lifetime Achievement award winners.
Hyatt Regency Hill Country Resort & Spa, 9800 Hyatt Resort Dr.


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