Saturday, September 05, 2015

UTSA brain research offers lead in treatment of Parkinson's disease

brain neurons

Dopaminergic neurons in the brain

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(May 14, 2010)--Researchers at the UTSA Neurosciences Institute are one step closer to understanding the physiology of dopaminergic neurons, the neurons in the brain that generally produce dopamine but die during Parkinson's disease.

Because dopaminergic neurons are the neurons that die during Parkinson's disease, and they also are the neurons affected when a drug user takes psycho-stimulants such as cocaine and amphetamine, the research has profound implications for public health.

Typically, dopaminergic neurons fire fast bursts of electrical activity. Scientists widely agree a protein called the NMDA receptor in the neuron's outer membrane has something to do with the ability to fire such fast bursts.

UTSA Assistant Professor Carlos Paladini and Professor Charles Wilson in the Department of Biology set out to learn how NMDA receptors cause bursts of firing in the brain's dopaminergic neurons. In a series of studies, the researchers observed that the NMDA receptor is highly sensitive to voltages. When the outer membrane's voltage is more positive, the NMDA receptor channel opens and leads to a single spike of electrical activity. When the outer membrane's voltage is more negative, the NMDA receptor channel closes and allows the neuron to recover from the previous spike of electrical activity.

Because the dopaminergic neuron's voltages quickly alternate between positive and negative, the result is NMDA receptors also quickly alternate between open and closed states. Voltage cues cause the NMDA receptors to oscillate rapidly several times between a spike of electrical activity one moment and silence the next, allowing dopaminergic neurons to fire a rapid burst of spikes: one spike with each NMDA receptor oscillation.

"For some reason, dopaminergic neurons are vulnerable in Parkinson's disease," said Paladini. "This study helps us better understand the physiology underlying their vulnerability."

 

 

Did You Know?

UTSA writes the book on all-digital libraries

As touch screens and e-books demand more and more attention from both casual readers and scholars, many people say the handwriting is on the wall for the printed page.

At UTSA, the handwriting is on the wall for a library that doesn't have any printed books.

Since March 2010, the bookless library in the Applied Engineering and Technology Building has given UTSA students an innovative way to read, research and work with each other to solve problems.

With ultra-modern furniture and a décor featuring desktop computers, scanners and LCD screens, the AET Library is designed to engage students in an online format. But it also offers group study niches and study rooms with whiteboards and glass walls on which students can write. The space encourages teamwork, communications and problem solving for the next generation of scientists and professional engineers.

Did you know? The UTSA AET Library is the nation's first completely bookless library on a college or university campus. It served as a model for Bexar County's first-in-the-nation public bookless library system and one of its branches, the Dr. Ricardo Romo BiblioTech.

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Events
Sept. 7, All Day

Labor Day Holiday

All campuses will be closed for the Labor Day holiday.
All Campuses

Sept. 9, 5:30 p.m.

Architecture Connects

The UTSA College of Architecture, Construction and Planning’s 2015-16 Speaker Series begins Sept. 9 with Toshiko Mori, the Robert P. Hubbard Professor in the Practice of Architecture at the Harvard University Graduate School of Design and principal of Manhattan-based Toshiko Mori Architect.
Buena Vista Building Aula Canaria (BV 1.328), Downtown Campus

Sept. 12, 11 a.m.

UTSA Football vs. Kansas State

Cheer on the UTSA Roadrunners at their home-opener against the Kansas State Wildcats.
Alamodome, 100 Montana St.

Sept. 15, 5:30 - 7 p.m.

Changing the Conversation: Recovery Works!

As part of National Recovery Month, a panel of substance abuse practitioners and members of the recovery community will discuss issues related to substance abuse treatment and recovery.
Durango Building 1.124 (DB 1.124), Downtown Campus

Sept. 24, 6 p.m.

The Power of Story in the Landscape of Memory and Identity

The UTSA College of Education and Human Development will host award-winning children’s author and illustrator Yuyi Morales. Morales will share personal stories that have influenced her work as an author and illustrator.
Buena Vista Building Aula Canaria (BV 1.328), Downtown Campus

Oct. 5, 9 a.m. - 3 p.m.

Civic Engagement Summit

This summit is an opportunity to showcase and share the variety of community engagement activities of UTSA students, faculty, and staff. The summit is currently accepting proposals for poster presentations. The Call for Posters deadline is Friday, Sept. 11.
University Center Denman Room (2.01.28), Main Campus


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