(June 7, 2010)--UTSA researchers are learning more about a fungus that can prove fatal for individuals with weakened immune systems.
Although the fungus Candida albicans is most often associated with superficial yeast infections, it also is extremely dangerous and a leading cause of hospital-acquired infections in the United States. Very often, those hospital-based infections are associated with the formation of biofilms or communities of microbes found on the surface of catheters, shunts and other medical devices inside patients. The biofilms promote infection by giving a fungus a safe place from which it can invade tissue, start new infection sites and resist treatment efforts.
Funded by the National Institute of Allergy and Infectious Diseases through the American Recovery and Reinvestment Act 2009, members of the South Texas Center for Emerging Infectious Diseases, Jose Lopez-Ribot, UTSA professor of microbiology, and Anand Ramasubramanian, UTSA assistant professor of biomedical engineering, are closely studying the life cycle of C. albicans in studies spearheaded by Priya Uppuluri, a talented postdoctoral fellow in the laboratory. Collaborators include the University of Texas Health Science Center at San Antonio and Children's Hospital in Boston.
In their research, the scientists used advanced modeling techniques to learn that the fungus continuously disperses to establish new sites of infection. That dispersal is regulated at the molecular level and is dependent upon environmental cues such as the availability of a carbon source and the pH of the biofilm's environment. Moreover, the cells dispersed from biofilms are more virulent than regular cells.
Ultimately, the findings are an important step in curbing candidiasis, an infection with a 30-50 percent mortality rate in patients with compromised immune systems.
"Candida infections are difficult to treat, extremely serious and often fatal," said Lopez-Ribot. "If we can uncover the factors the fungus is dependent upon to survive and proliferate, we can begin to develop treatments that will prevent the spread of the infection."
The American Recovery and Reinvestment Act 2009 is an economic recovery package adopted to help states stabilize budgets and stimulate economic growth. Stimulus funding will be allocated, in part, to modernize health care, improve schools, modernize infrastructure and invest in the clean energy technologies of the future.
The Spring Research Conference offers graduate and undergraduate students pursuing majors in the College of Liberal and Fine Arts the opportunity to present their original work in a forum of interested and critically engaged minds that is at the same time welcoming and inclusive.
Various locations, Main Campus
Mimi Marziani, executive director of the Texas Civil Rights Project, will speak about civil rights advocacy, political campaigns, election law and nonprofit management.
SAWS Headquarters, 2800 U.S. Highway 281 North, San Antonio
Join the Center for Military Families for a panel on Politics in the Service of Military Families, featuring Cedric Leighton, David Splitter, Steve Huerta, and the Office of Congressman Henry Cuellar. The event is free and open to the public.
Buena Vista Street Building, Aula Canaria Lecture Hall (BVB 1.328), Downtown Campus
UTSA Dance classes will take the stage and share their talents and passion for dance! Come support our growing dance program! $10 admission
Buena Vista Street Building Theater (BVB 1.326), Downtown Campus
This panel presentation will look at the history of the YWCA and the impact the organization has had on women in the San Antonio community.
McKinney Humanities Building (MH 2.02.10), Main Campus
The Demography Lecture Series continues with Dr. Barbara Bird of American University. Her topic focuses on Insights Into a Hard to Find Population: Latino Entrepreneurs in Metro Washington, D.C. Event is free and open to the public. Parking is available in the pay stall spaces of the Monterrey surface lot.
Monterrey Building (MNT 3.240), Downtown Campus
This video tells the story of four Latina lesbians who fought for exoneration after being wrongfully convicted of sexually assaulting two girls during the Satanic Panic witch-hunt era of the 1980s and 1990s.
North Paseo Building (NPB 1.114), Main Campus
Tejana/Indígena author Ire'ne Lara Ailva will read from her latest work and discuss her approach to reimagining Tejan@ myths.
Main Building (MB 2.404), Main Campus
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
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