(June 7, 2010)--UTSA researchers are learning more about a fungus that can prove fatal for individuals with weakened immune systems.
Although the fungus Candida albicans is most often associated with superficial yeast infections, it also is extremely dangerous and a leading cause of hospital-acquired infections in the United States. Very often, those hospital-based infections are associated with the formation of biofilms or communities of microbes found on the surface of catheters, shunts and other medical devices inside patients. The biofilms promote infection by giving a fungus a safe place from which it can invade tissue, start new infection sites and resist treatment efforts.
Funded by the National Institute of Allergy and Infectious Diseases through the American Recovery and Reinvestment Act 2009, members of the South Texas Center for Emerging Infectious Diseases, Jose Lopez-Ribot, UTSA professor of microbiology, and Anand Ramasubramanian, UTSA assistant professor of biomedical engineering, are closely studying the life cycle of C. albicans in studies spearheaded by Priya Uppuluri, a talented postdoctoral fellow in the laboratory. Collaborators include the University of Texas Health Science Center at San Antonio and Children's Hospital in Boston.
In their research, the scientists used advanced modeling techniques to learn that the fungus continuously disperses to establish new sites of infection. That dispersal is regulated at the molecular level and is dependent upon environmental cues such as the availability of a carbon source and the pH of the biofilm's environment. Moreover, the cells dispersed from biofilms are more virulent than regular cells.
Ultimately, the findings are an important step in curbing candidiasis, an infection with a 30-50 percent mortality rate in patients with compromised immune systems.
"Candida infections are difficult to treat, extremely serious and often fatal," said Lopez-Ribot. "If we can uncover the factors the fungus is dependent upon to survive and proliferate, we can begin to develop treatments that will prevent the spread of the infection."
The American Recovery and Reinvestment Act 2009 is an economic recovery package adopted to help states stabilize budgets and stimulate economic growth. Stimulus funding will be allocated, in part, to modernize health care, improve schools, modernize infrastructure and invest in the clean energy technologies of the future.
Lisa Carrington Firmin, UTSA associate provost for veteran and military affairs, will deliver the keynote at this summit where veterans and professional leaders will share best practices regarding veteran-related opportunities.
The Club at Sonterra, 901 Sonterra Blvd., San Antnio
Campers in 9th grade through college will receive instruction and coaching on agility testing and position specific drills to refine and improve his skillset as a football player.
Recreational Field Complex, Main Campus
Inspired by UTSA's renowned Mexican Cookbook Collection, the evening features cuisine and spirits of celebrated chefs from San Antonio and Mexico.
Hotel Emma, 136 E. Grayson St., San Antonio
Experience a fun, interactive week at UTSA as new students and their families take the first steps to becoming a Roadrunner.
Various locations, Main Campus
Campers 6-12 years old will enjoy the summer learning to read, write and speak the Chinese language. They also will learn about the Chinese culture such as martial arts, painting and drawing, arts and crafts and more.
Confucius Institute at UTSA (MB 1.208), Main Campus
Campers 7th grade and up will focus on individual development with emphasis on simplifying and teaching the specific skills and movements associated with the game. Serving, passing, setting, attacking and individual defense will all be covered. In addition, team concepts will be emphasized.
Convocation Center, Main Campus
Celebrate Texas' diversity with authentic ethnic cuisine, music, dance, arts and crafts from the many countries that make up the rich heritage of Texas.
UTSA Institute of Texan Cultures, Hemisfair Campus
Get kids from kindergarten through high school interested in the fields of science, technology, engineering and math through hands-on activities at UTSA iTEC camps. The instructors go beyond the classroom and understand that kids learn more when they are excited about the topics they’re discovering.
Applied Engineering and Technology (AET 0.102), Main Campus and Buena Vista Street Building (BVB 3.328), Downtown Campus
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