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New patent propels UTSA biology researchers toward tularemia vaccine development

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(July 2, 2010)--Karl Klose, director of the UTSA South Texas Center Emerging Infectious Diseases (STCEID), and Bernard Arulanandam, associate dean of research for scientific innovation in the UTSA College of Sciences, have been granted a U.S. patent for developing a process to create a vaccine for the deadly tularemia infection.

Tularemia, caused by the highly infectious bacterium Francisella tularensis, can cause serious disease in humans. F. tularensis is carried primarily by animals such as rabbits and rarely causes human infections, but when breathed in through the lungs, the disease can be fatal. Because of this, F. tularensis is considered a potential bioweapon.

"We developed what is called a 'live attenuated vaccine,' by removing Francisella's IglD gene, which is critical for the bacteria to be able to survive and grow inside infected cells," said Klose. "In a series of studies over three years, we characterized the IglD gene, knocked it out, and observed that the crippled bacterium was able to act as an effective vaccine by inducing an immune response without causing tularemia. This research is a promising advance in our attempts to develop a vaccine against this potential bioweapon."

F. tularensis is one of many organisms the researchers in the STCEID are investigating with an eye for vaccine development. Researchers are also working on vaccines for Valley Fever, Lyme disease and anthrax.

As UTSA continues to move toward Tier One research status, it has developed an increased focus on innovation, commercialization and technology transfer.

"Last year, UTSA signed its first commercial license to develop a chlamydia vaccine with pharmaceutical company Merck based on research from our South Texas Center for Emerging Infectious Diseases and the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio," said Arulanandam. "We are hopeful that the science behind this new patent for Francisella will spur further insight into the creation of an effective vaccine against this pathogen."

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The South Texas Center for Emerging Infectious Diseases (STCEID) focuses on research in molecular microbiology, immunology, medical mycology, virology, microbial genomics, vaccine development and biodefense. The center also provides hands-on training to undergraduate and graduate students who intend to pursue careers in science and technology. Working with the UTSA College of Sciences Department of Biology, center faculty have established an undergraduate academic track in microbiology, a master's program in biology and biotechnology and a Ph.D. program in cell and molecular biology.

 

 

Events
Feb. 13, 10 a.m. - 5 p.m.

29th annual Asian Festival - Year of the Monkey

The UTSA Institute of Texan Cultures invites Texas and Texans to the Asian Festival. What began as a traditional family reunion for the Chinese New Year has expanded to include other Asian communities and participants, showcasing their unique culture and traditions.
The UTSA Institute of Texan Cultures

Feb. 13, 1 p.m.

2016 Interdisciplinary Studies Colloquium

Join the UTSA Department of Interdisciplinary Learning and Teaching in celebrating interdisciplinary inquiry at the 2016  Interdisciplinary Studies Colloquium.  The colloquium will include a panel of faculty and recent doctoral graduate and a showcase of the best IDS undergraduate inquiry projects of the year 2015. The event is free and open to the public.
Business Building (BB 2.06.04), UTSA Main Campus

Feb. 16, 8:30 - 11:30 a.m.

S.T.E.M. Career Fair

Are you looking for career opportunities in Science, Technology, Engineering or Math? Come to the SPRING 2015 STEM Career Fair. Recruiters from across the STEM fields will be present with full-time, part-time and/or internship opportunities. Professional dress is required. Bring plenty of resumes! Download the UTSA Career Fair Plus App on iOS and Android.
Convocation Center, Main Campus

Feb. 16, 1:30 - 4:30 p.m.

Spring 2016 All Majors Career & Internship Fair

Come to the Spring 2016 All Majors and Internship Career Fair. Recruiters from across all industries will be present with full-time or internship opportunities. Professional Dress is Required. Bring plenty of resumes! Download the UTSA Career Fair Plus App on iOS and Android.
Convocation Center, Main Campus

Feb. 17, 5:30 p.m.

CACP Speaker Series continues with Cesar Pelli

The UTSA College of Architecture, Construction and Planning (CACP) welcomes renowned architect Cesar Pelli as part of the CACP’s 2015-16 Speaker Series. Pelli is founder and Senior Principal of the New Haven, Conn. firm Pelli Clarke Pelli Architects. In his talk, “Becoming an Architect,” Pelli will present and discuss projects that were critical steps in his career.
Buena Vista Theater (BV 1.326), Downtown Campus

Feb. 23, 5:30 p.m.

African-American Social Welfare Pioneers Responding to Community Needs

The UTSA College of Public Policy presents the Dean's Distinguished Lecture Series featuring Dr. Iris Carlton-LaNey, Professor of the School of Social Work at the University of North Carolina-Chapel Hill. Dr. Iris Carlton LaNey will speak to the UTSA community about the role and impact of African-Americans in the social work profession.
Buena Vista Theater (BV 1.326), Downtown Campus

Feb. 23, 5:30 p.m.

African-American Social Welfare Pioneers Responding to Community Needs

The UTSA College of Public Policy presents the Dean's Distinguished Lecture Series featuring Dr. Iris Carlton-LaNey, Professor of the School of Social Work at the University of North Carolina-Chapel Hill. Dr. Carlton-LaNey will speak to the UTSA community about the role and impact of African-Americans in the social work profession.
Buena Vista Theater (BV 1.326), Downtown Campus

Feb. 23, 7 p.m.

Presentation and Book Signing with Luis Carlos Montalvan

Please join us for a presentation and book signing by Luis Carlos Montalván (Fmr. Capt., USA), author of the New York Times Bestseller Until Tuesday and the international award-winning childrens book Tuesday Tucks Me In. His books will be available for purchase at the UTSA Bookstore. This event is free and open to the public.
Southwest Room (DB 1.124), Downtown Campus

Feb. 25, 6 p.m.

12th Annual Black Heritage Gala

The 12th Annual Black Heritage Gala is a formal event which includes a student performance, keynote remarks by Michael Brown, an award presentation, dinner and dancing. Tickets are $10 for UTSA students and $15 for all other guests. Tickets are on sale now at Roadrunner Express. Contact (210) 458-4770 for more information.
H-E-B University Center Ballroom, Main Campus

Feb. 27, 9 a.m.

Cultural Contrasts in Latin America

The UTSA Institute of Texan Cultures will host a free workshop focusing on teaching Latin American culture and geography for students seeking their teacher certification. The workshop includes free resources for teaching Latin American subject matter as well as presentations on language, identity, music, geography, and political and developmental history, and a special educators’ tour of the museum’s Los Tejanos exhibit. Free with registration.
The UTSA Institute of Texan Cultures (ITC 3.01.02)


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