(July 2, 2010)--Karl Klose, director of the UTSA South Texas Center Emerging Infectious Diseases (STCEID), and Bernard Arulanandam, associate dean of research for scientific innovation in the UTSA College of Sciences, have been granted a U.S. patent for developing a process to create a vaccine for the deadly tularemia infection.
Tularemia, caused by the highly infectious bacterium Francisella tularensis, can cause serious disease in humans. F. tularensis is carried primarily by animals such as rabbits and rarely causes human infections, but when breathed in through the lungs, the disease can be fatal. Because of this, F. tularensis is considered a potential bioweapon.
"We developed what is called a 'live attenuated vaccine,' by removing Francisella's IglD gene, which is critical for the bacteria to be able to survive and grow inside infected cells," said Klose. "In a series of studies over three years, we characterized the IglD gene, knocked it out, and observed that the crippled bacterium was able to act as an effective vaccine by inducing an immune response without causing tularemia. This research is a promising advance in our attempts to develop a vaccine against this potential bioweapon."
F. tularensis is one of many organisms the researchers in the STCEID are investigating with an eye for vaccine development. Researchers are also working on vaccines for Valley Fever, Lyme disease and anthrax.
As UTSA continues to move toward Tier One research status, it has developed an increased focus on innovation, commercialization and technology transfer.
"Last year, UTSA signed its first commercial license to develop a chlamydia vaccine with pharmaceutical company Merck based on research from our South Texas Center for Emerging Infectious Diseases and the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio," said Arulanandam. "We are hopeful that the science behind this new patent for Francisella will spur further insight into the creation of an effective vaccine against this pathogen."
The South Texas Center for Emerging Infectious Diseases (STCEID) focuses on research in molecular microbiology, immunology, medical mycology, virology, microbial genomics, vaccine development and biodefense. The center also provides hands-on training to undergraduate and graduate students who intend to pursue careers in science and technology. Working with the UTSA College of Sciences Department of Biology, center faculty have established an undergraduate academic track in microbiology, a master's program in biology and biotechnology and a Ph.D. program in cell and molecular biology.
This high school student exhibit features images, videos, interviews and writings that the students learned about while participating in "The Will to Adorn: African American Dress and the Aesthetics of Identity."
Institute of Texan Cultures, Hemisfair Campus
UTSA has a greater focus in 2018 to serve the local community. Learn the many opportunities you can get involved.
Student Union, 1st floor corridor, Main Campus
Dr. Ricky Jones, professor and chair of the Department of Pan-African studies at the University of Louisville. He will share his expertise on the impact of African American history on today’s society.
Student Union, Retama Auditorium (UC 2.02.02), Main Campus
Come meet STEM recruiters in person from companies across the nation that have full-time, part-time and/or internship opportunities.
Convocation Center, Main Campus
The summit is an opportunity to create an open forum for the community to share ideas and perspectives on civic engagement.
H-E-B University Center Ballroom (HUC 1.104), Main Campus
Meet recruiters in person from companies across the nation that have full-time and/or internship opportunities. Professional dress required.
Convocation Center, Main Campus
New exhibit of Latino and Latina artists is curated by Arturo Infante Almeida, art specialist and curator for the UTSA Art Collection. Opening Reception is Feb. 8; exhibit runs through June 10.
Centro de Artes Gallery, 102 S. Santa Rosa, San Antonio
The UTSA commnity is encouraged to get involved in this city-wide initiative to clean up the San Antonio area waterways. Roadsrunners will be cleaning up Maverick Creek on the west side of Main Campus.
Maverick Creek, Main Campus
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