(Nov. 30, 2010)--Lutcher Brown Distinguished Chair Donald Kurtz in the UTSA Department of Chemistry has been selected to receive $199,906 from the Cancer Prevention and Research Institute of Texas (CPRIT) to develop a novel approach to delivering iron at toxic levels to kill cancer cells and tumors. The two-year research project is considered "High Impact High Risk" and if successful could have a tremendous impact on cancer therapy.
"Iron is essential for all cells in the body to function properly and is safe up to certain levels -- however, the cells' iron transfer process is highly regulated," said Kurtz. "If we overload cells or tissues with iron, it becomes toxic. Our goal is to develop a method for delivering iron at toxic levels specifically to cancer cells."
Over the next two years, Kurtz and his research team will focus on developing a photochemical or light-activated cancer therapy. A nano-scale protein scaffold filled with approximately 2,000 iron atoms in its hollow center will drive the treatment. The scaffold will include peptides on its outer shell that will allow it to be recognized specifically by cancer cells. The peptides would make the scaffold bind to the cancer cells like Velcro.
Once researchers deliver the iron-loaded scaffold to cancer cells, they will zap the scaffold with tissue-penetrating, near-infra-red light. The light treatment will cause the scaffold to release its iron into the cells. The released iron will induce the production of free radicals, which, at sufficiently high levels, will overwhelm the cell's anti-oxidant capacity -- thereby killing the cells. The peptide on the outer shell of the protein scaffold can be varied to target specific types of cancers such as breast or prostate.
"The basic idea is to use light as the trigger to shoot iron out of our protein scaffold and into the cancer cells," said Kurtz. "Think of it as shooting iron bullets to kill cancer." Kurtz joined UTSA's faculty in 2006 after serving 20 years on the chemistry faculty at the University of Georgia. He is a specialist in bioinorganic chemistry and studies metalloenzymes such as non-heme iron enzymes at the molecular level.
Established by Texas voters in 2007, CPRIT will invest up to $3 billion for groundbreaking cancer research, prevention programs and services in Texas.
State Rep. Diego Bernal presents a Q&A panel discussion with MALDEF, RAICES and DMCA Immigration Law Firm about DACA and the current state of affairs for Dreamers. Opening remarks by Congressman Joaquin Castro and Congressman Lloyd Doggett.
Buena Vista Building, Aula Canaria Auditorium (BVB 1.328), Downtown Campus
Come out and enjoy breakfast and beverages at the Official UTSA Tailgate in Albuquerque as our Roadrunners take on the New Mexico Lobos at the Gildan New Mexico Bowl. The official UTSA tailgate will be located in Fan Fest in the University Stadium Parking Lot, Stadium East.
University Stadium parking lot, Albuquerque, NM
Graduates from the College of Architecture, Construction and Planning, College of Business, College of Education and Human Development and the College of Public Policy will participate in the first commencement ceremony. President Romo will deliver the keynote address.
Graduates from the College of Engineering, College of Liberal and Fine Arts, College of Sciences and University College will participate in the second commencement ceremony. President Romo will deliver the keynote address.
All UTSA students, faculty and staff are invited to march with UTSA in the 30th annual MLK March. There will be a FREE shuttle from the UTSA Main Campus. Pick up in front of the Convocation Center at 8:30 a.m. Depart from UTSA at 9 a.m. Buses return to UTSA at 1 p.m
Convocation Center, Main Campus
UTSA's Department of Music hosts Dr. David Huron from Ohio State University as part of the Donald Hodges lecture series. Huron is a Canadian arts and humanities distinguished professor at Ohio State University.
John Peace Library, UTSA Faculty Center, (JPL 4.04.22), Main Campus
The Student Center for Community Engagement and Inclusion annually hosts a Volunteer Opportunities Fair to allow students, faculty and staff to learn about volunteer and service-learning opportunities in the San Antonio area.
University Center, 1st floor corridor, Main Campus
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