Monday, August 03, 2015

$200K grant to aid UTSA chemist Donald Kurtz in researching cancer therapy

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Iron (left) attacks cancer cell

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(Nov. 30, 2010)--Lutcher Brown Distinguished Chair Donald Kurtz in the UTSA Department of Chemistry has been selected to receive $199,906 from the Cancer Prevention and Research Institute of Texas (CPRIT) to develop a novel approach to delivering iron at toxic levels to kill cancer cells and tumors. The two-year research project is considered "High Impact High Risk" and if successful could have a tremendous impact on cancer therapy.

"Iron is essential for all cells in the body to function properly and is safe up to certain levels -- however, the cells' iron transfer process is highly regulated," said Kurtz. "If we overload cells or tissues with iron, it becomes toxic. Our goal is to develop a method for delivering iron at toxic levels specifically to cancer cells."

Over the next two years, Kurtz and his research team will focus on developing a photochemical or light-activated cancer therapy. A nano-scale protein scaffold filled with approximately 2,000 iron atoms in its hollow center will drive the treatment. The scaffold will include peptides on its outer shell that will allow it to be recognized specifically by cancer cells. The peptides would make the scaffold bind to the cancer cells like Velcro.

Once researchers deliver the iron-loaded scaffold to cancer cells, they will zap the scaffold with tissue-penetrating, near-infra-red light. The light treatment will cause the scaffold to release its iron into the cells. The released iron will induce the production of free radicals, which, at sufficiently high levels, will overwhelm the cell's anti-oxidant capacity -- thereby killing the cells. The peptide on the outer shell of the protein scaffold can be varied to target specific types of cancers such as breast or prostate.

"The basic idea is to use light as the trigger to shoot iron out of our protein scaffold and into the cancer cells," said Kurtz. "Think of it as shooting iron bullets to kill cancer." Kurtz joined UTSA's faculty in 2006 after serving 20 years on the chemistry faculty at the University of Georgia. He is a specialist in bioinorganic chemistry and studies metalloenzymes such as non-heme iron enzymes at the molecular level.

Established by Texas voters in 2007, CPRIT will invest up to $3 billion for groundbreaking cancer research, prevention programs and services in Texas.

 

 

Did You Know?

UTSA researcher is a star behind the cloud

A revolution in cloud computing is underway, and Ravi Sandhu believes it will be much bigger than the PC and Internet revolutions that have already changed the way we live. Sandhu, director of the UTSA Institute for Cyber Security, says UTSA is taking a leadership role in tackling three fundamental cloud technology problems: how to build and operate the cloud, how to use it profitably for diverse applications and how to keep it secure.

Sandhu, the Lutcher Brown Distinguished Chair in Cyber Security in the College of Sciences, and Ram Krishnan, assistant professor of electrical engineering in the UTSA College of Engineering, are funded by a $500,000 grant from the National Science Foundation to improve cloud security.

Did you know? Sandhu, a world-renowned cybersecurity expert, holds 30 patents, has authored more than 250 papers and been cited more than 30,000 times.

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Aug. 1, 9 p.m.

"Inside Peace" documentary screening

This documentary, presented by the San Antonio Film Festival, documents the experience of re-entry after incarceration. The film features Michael Gilbert, associate professor in the department of criminal justice and director of the Office of Community and Restorative Justice program at UTSA.
Tobin Center for the Performing Arts, 100 Auditorium Circle

Aug. 4, 6 - 8 p.m.

Free Teacher Tuesday: Los Tejanos Workshop

Discover resources and strategies for teaching Tejano history and culture and get a special educator's tour of the new long-term exhibit, Los Tejanos.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 6, 5 - 7 p,m,; 9 a.m. - 3:30 p.m.

6th Annual Texas Higher Education Symposium

This annual symposium is an opportunity to discuss Texas higher education issues and trends with Texas higher education scholars, state and local government officials, students, and campus and local community members.
Downtown Campus

Aug. 9, 12 - 5 p.m.

Vaquerocation 2015

This cowboy-themed programming, offered in conjunction with Our Kids Magazine's Kidcation Week, gives families the opportunity to visit with cowboy docents, enjoy readings and visit activity tables.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 17, 11:30 p.m.

Midnight Light

Join President Ricardo Romo, The Spirit of San Antonio Marching Band, students, faculty and staff to light the monument at the Main Campus entrance at the stroke of midnight.
John Peace Boulevard Entrance, Main Campus

Aug. 18, 11 a.m. - 1 p.m.

President's BBQ on the Plaza

Join university President Ricardo Romo on the Bill Miller Plaza for his annual free BBQ lunch.
Bill Miller Plaza, Downtown Campus

Aug. 18, 5:30 p.m. - 7:30 p.m.

President's BBQ on the Lawn

Join university President Ricardo Romo on the Convocation Center lawn for his annual free BBQ lunch.
Convocation Center East Lawn, Main Campus

Aug. 22, 6 p.m.

UTSA Alumni Gala

The UTSA Alumni Association hosts this annual gala honoring the Alumna of the Year, Alumnus of the Year and the Alumnus of the Year Lifetime Achievement award winners.
Hyatt Regency Hill Country Resort & Spa, 9800 Hyatt Resort Dr.


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