(Nov. 30, 2010)--Lutcher Brown Distinguished Chair Donald Kurtz in the UTSA Department of Chemistry has been selected to receive $199,906 from the Cancer Prevention and Research Institute of Texas (CPRIT) to develop a novel approach to delivering iron at toxic levels to kill cancer cells and tumors. The two-year research project is considered "High Impact High Risk" and if successful could have a tremendous impact on cancer therapy.
"Iron is essential for all cells in the body to function properly and is safe up to certain levels -- however, the cells' iron transfer process is highly regulated," said Kurtz. "If we overload cells or tissues with iron, it becomes toxic. Our goal is to develop a method for delivering iron at toxic levels specifically to cancer cells."
Over the next two years, Kurtz and his research team will focus on developing a photochemical or light-activated cancer therapy. A nano-scale protein scaffold filled with approximately 2,000 iron atoms in its hollow center will drive the treatment. The scaffold will include peptides on its outer shell that will allow it to be recognized specifically by cancer cells. The peptides would make the scaffold bind to the cancer cells like Velcro.
Once researchers deliver the iron-loaded scaffold to cancer cells, they will zap the scaffold with tissue-penetrating, near-infra-red light. The light treatment will cause the scaffold to release its iron into the cells. The released iron will induce the production of free radicals, which, at sufficiently high levels, will overwhelm the cell's anti-oxidant capacity -- thereby killing the cells. The peptide on the outer shell of the protein scaffold can be varied to target specific types of cancers such as breast or prostate.
"The basic idea is to use light as the trigger to shoot iron out of our protein scaffold and into the cancer cells," said Kurtz. "Think of it as shooting iron bullets to kill cancer." Kurtz joined UTSA's faculty in 2006 after serving 20 years on the chemistry faculty at the University of Georgia. He is a specialist in bioinorganic chemistry and studies metalloenzymes such as non-heme iron enzymes at the molecular level.
Established by Texas voters in 2007, CPRIT will invest up to $3 billion for groundbreaking cancer research, prevention programs and services in Texas.
As part of the International Cooking Series, the experts in the UTSA Demo Kitchen will show you how to make this stuffed bread Latin dish. Register for this cooking demo here.
Recreation Wellness Center Demo Kitchen, Main Campus
UTSA's annual sustainability festival, showcases the university’s and the City of San Antonio’s progress on researching and developing sustainable solutions to improve the quality life for future generations.
H-E-B University Center Ballroom (HUC 1.104), Main Campus
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Institute of Texan Cultures, Hemisfair Campus
Get involved and register to vote. Click on the link to find out the locations on the Main and Downtown Campuses.
Multiple locations on the Main and Downtown Campuses
Learn about products and services available for studying, working, and making it to graduation! Speak directly to OIT managers, provide feedback on UTSA tech, and have your voice heard! Lunch and OIT gear provided. RSVP at: www.utsa.edu/oit/sic.
University Center, Denman Ballroom (2.01.28), Main Campus
Come meet the candidates looking to take home the crown as Mr. and Ms. UTSA 2017-2018. This is your opportunity to hear the candidates platform and learn how they plan to represent and transform UTSA.
University Center, Retama Auditorium (UC 2.02.02), Main Campus
UTSA's Friends of Shakespeare hosts this annual performance seried by Actors from the London Stage, Sept. 27, 29 and 30 at 7:30 p.m.
Arts Building, Recital Hall (ARTS 2.03.02), Main Campus
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UTSA Institute of Texan Cultures, Hemisfair Campus
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