(Dec. 1, 2010)--UTSA professors Anand Ramasubramanian in the College of Engineering Department of Biomedical Engineering and Jose Lopez-Ribot in the College of Sciences Department of Biology and South Texas Center for Emerging Infectious Diseases (STCEID) have developed a prototype nanochip that can accelerate testing in drug delivery and diagnostics.
The chip uses high-throughput screening, which is technology that allows researchers to test simultaneously hundreds of thousands of small molecules for specific characteristics.
"This project started when Dr. Lopez-Ribot and I met at an interdisciplinary seminar held at UTSA," said Ramasubramanian. "We talked about his Candida albicans research, and he said that the current industry standard is 96 well plates. We thought there had to be a better way. There had to be a way to leverage today's technology to achieve faster testing."
Following the seminar, the researchers began talking about applying their ideas in practice. Shortly thereafter, with assistance from Anand Srinivasan, a graduate student in biomedical engineering, and Priya Uppuluri, a post-doctoral researcher in biology, they began developing a high-throughput nanochip to screen potential antifungal drug candidates for Candida albicans. Often fatal to individuals with weakened immune systems, this fungal organism is the third most common hospital-derived infection in the United States.
With grants from the UTSA Office for Research Commercialization and Innovation Proof of Concept fund and the University of Texas Health Science Center's Institute for the Integration of Medicine and Science, and capital equipment support from the STCEID, the researchers developed a nanochip comprised of 768 equivalent and spatially distinct Candida albicans nano-biofilms on a single microscope glass slide.
The chip already has shown to be effective in research, offering advantages including:
Now that a prototype has been created, Ramasubramanian and Lopez-Ribot are testing large libraries of compounds for potential anti-fungal activity. Ramasubramanian recently received funds from the Semp Russ Foundation of the San Antonio Area Foundation and from the San Antonio Life Sciences Institute to develop separate high-throughput chips to diagnose chlamydial infection and to screen potential breast cancer drug candidates.
The project will be in collaboration with researchers from UTSA's STCEID and the UT Health Science Center at San Antonio. Shankar Evani, a research fellow in Ramasubramanian's laboratory will assist in the effort. Lopez-Ribot is the recipient of grants from the NIH National Institute of Allergy and Infectious Diseases to study C. albicans biofilms and the pathogenesis of candidiasis.
With the long-term view of successful technology commercialization, the UTSA Center for Innovation and Technology Entrepreneurship (CITE) teams researchers with graduate students in the UTSA Management of Technology program to create a strategic technology business plan that assesses the market potential and outlines the technology roadmap necessary to bridge the gap between research development and new technology venture.
"These are the kind of synergies we can create at UTSA, bringing together phenomenal research innovation with targeted class projects that both improve the educational model for our students and help propel technology from our laboratories into the market," said Cory Hallam, CITE founding director.
The UTSA East Asia Institute hosts District 8 City Councilman Ron Nirenberg who will discuss his recent trip to China for the 8th annual Sister Cities International forum. He will discuss how these conversations help citizens connect in an increasingly global world to exchange ideas and tackle issues affecting all of us.
University Center, Denman Room (UC 2.01.28), Main Campus
Antonio Petrov, assistant professor in the UTSA College of Architecture, Construction and Planning, invites San Antonio to engage in dialogue to gather a broad understanding of Puro. he symposium, which includes UTSA masters students, will be led by community members who embody the term. It's free and open to the public.
Brick at Blue Star Arts Complex, Bldg. 108, 1414 S. Alamo St., San Antonio
Dr. Gaye Theresa Johnson, associate professor of Chicana and Chicano Studies, and African American Studies, at the University of California at Los Angeles is the guest speaker at this free, open event. Johnson is also the author of "Spaces of Conflict Sounds of Solidarity: Music, Race, and Spacial Entitlement in Los Angeles" and "Futures of Black Radicalism."
University Center, Denman Room (UC 02.01.28), Main Campus
The UTSA Consortium for Social Transformation; African American Studies Program presents guest speaker Dr. Gaye Theresa Johnson, associate professor of Chicana and Chicano Studies, and African American Studies, University of California at Los Angelesand author of "Spaces of Conflict Sounds of Solidarity: Music, Race, and Spacial Entitlement in Los Angeles" and "Futures of Black Radicalism." The event is free and open to the public.
University Center, Denman Room (UC 2.01.28), Main Campus
Grab your friends, family, kids and dog for this annual fun run on the UTSA Main Campus benefititng the UTSA Alumni Association.
Convocation Center, Main Campus
Join the Department of Interdisciplinary Learning and Teaching for the 13th annual Storytelling Festival. The festival will feature keynote speaker Carolina Quiroga-Stultz, a Colombian Storyteller and journalist. This event is free and open to the public.
Main Building, ground floor, Main Campus
The IDS Colloquium showcases the excellent scholarship done by the IDS students in the College of Education and Human Development at UTSA. In addition, this event also honors the legacy of Dr. Marian Martinello.
Business Building, University Room (BB 2.06.04), Main Campus
The Department of Biology and the Be the Match Team will collaborate to engage and educate our students in the importance of a life saving donation through peripheral blood stem cells and a marrow harvest.
UC Paseo and Central Plaza, Main Campus
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
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