(Dec. 1, 2010)--UTSA professors Anand Ramasubramanian in the College of Engineering Department of Biomedical Engineering and Jose Lopez-Ribot in the College of Sciences Department of Biology and South Texas Center for Emerging Infectious Diseases (STCEID) have developed a prototype nanochip that can accelerate testing in drug delivery and diagnostics.
The chip uses high-throughput screening, which is technology that allows researchers to test simultaneously hundreds of thousands of small molecules for specific characteristics.
"This project started when Dr. Lopez-Ribot and I met at an interdisciplinary seminar held at UTSA," said Ramasubramanian. "We talked about his Candida albicans research, and he said that the current industry standard is 96 well plates. We thought there had to be a better way. There had to be a way to leverage today's technology to achieve faster testing."
Following the seminar, the researchers began talking about applying their ideas in practice. Shortly thereafter, with assistance from Anand Srinivasan, a graduate student in biomedical engineering, and Priya Uppuluri, a post-doctoral researcher in biology, they began developing a high-throughput nanochip to screen potential antifungal drug candidates for Candida albicans. Often fatal to individuals with weakened immune systems, this fungal organism is the third most common hospital-derived infection in the United States.
With grants from the UTSA Office for Research Commercialization and Innovation Proof of Concept fund and the University of Texas Health Science Center's Institute for the Integration of Medicine and Science, and capital equipment support from the STCEID, the researchers developed a nanochip comprised of 768 equivalent and spatially distinct Candida albicans nano-biofilms on a single microscope glass slide.
The chip already has shown to be effective in research, offering advantages including:
Now that a prototype has been created, Ramasubramanian and Lopez-Ribot are testing large libraries of compounds for potential anti-fungal activity. Ramasubramanian recently received funds from the Semp Russ Foundation of the San Antonio Area Foundation and from the San Antonio Life Sciences Institute to develop separate high-throughput chips to diagnose chlamydial infection and to screen potential breast cancer drug candidates.
The project will be in collaboration with researchers from UTSA's STCEID and the UT Health Science Center at San Antonio. Shankar Evani, a research fellow in Ramasubramanian's laboratory will assist in the effort. Lopez-Ribot is the recipient of grants from the NIH National Institute of Allergy and Infectious Diseases to study C. albicans biofilms and the pathogenesis of candidiasis.
With the long-term view of successful technology commercialization, the UTSA Center for Innovation and Technology Entrepreneurship (CITE) teams researchers with graduate students in the UTSA Management of Technology program to create a strategic technology business plan that assesses the market potential and outlines the technology roadmap necessary to bridge the gap between research development and new technology venture.
"These are the kind of synergies we can create at UTSA, bringing together phenomenal research innovation with targeted class projects that both improve the educational model for our students and help propel technology from our laboratories into the market," said Cory Hallam, CITE founding director.
Recruiters from across all fields looking to hire students with all different majors will be present at this event looking to hire for their full-time and/or internship opportunities. Dress professionally and bring lots of resumes.
H-E-B University Center Ballroom (HUC 1.104), Main Campus
The UTSA Institute for P-20 Initiatives hosts this free breakfast to kick off a new school year and a new opportunity to volunteer at mentoring organizations in our community.
Whataburger, 8680 Fourwinds Dr., San Antonio
As part of the International Cooking Series, the experts in the UTSA Demo Kitchen will show you how to make this stuffed bread Latin dish. Register for this cooking demo here.
Recreation Wellness Center Demo Kitchen, Main Campus
UTSA's annual sustainability festival, showcases the university’s and the City of San Antonio’s progress on researching and developing sustainable solutions to improve the quality life for future generations.
H-E-B University Center Ballroom (HUC 1.104), Main Campus
The institute will feature a performance from Eva Ybarra, the “Queen of the Accordion.” Manuel Medrano will premiere a documentary on Ybarra’s career. Two people receive free admission with a voucher available here.
Institute of Texan Cultures, Hemisfair Campus
Get involved and register to vote. Click on the link to find out the locations on the Main and Downtown Campuses.
Multiple locations on the Main and Downtown Campuses
Learn about products and services available for studying, working, and making it to graduation! Speak directly to OIT managers, provide feedback on UTSA tech, and have your voice heard! Lunch and OIT gear provided. RSVP at: www.utsa.edu/oit/sic.
University Center, Denman Ballroom (2.01.28), Main Campus
Come meet the candidates looking to take home the crown as Mr. and Ms. UTSA 2017-2018. This is your opportunity to hear the candidates platform and learn how they plan to represent and transform UTSA.
University Center, Retama Auditorium (UC 2.02.02), Main Campus
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