(May 23, 2012) ---University of Texas at San Antonio (UTSA) alumna Jordan Kaufmann, Ph.D.; UTSA College of Engineering Dean Mauli Agrawal; and UT Medicine San Antonio cardiologist Steven Bailey, M.D., have launched Cardiovate, a technology start-up that will offer a new and much-needed cardiovascular stent-graft to prevent aneurysm leakage following cardiovascular surgeries.
Kaufmann, an alumna of the UTSA College of Engineering's Department of Biomedical Engineering, developed the stent-graft as part of her doctoral research with UTSA's Agrawal and Bailey, division chief for cardiology in the School of Medicine of the UT Health Science Center San Antonio.
"To take an idea that we were throwing around and develop it all the way to a product for a start-up company has been an incredible opportunity," said Kaufmann. "The path epitomized both translational research and multidisciplinary studies, which has been a great educational experience."
Approximately 1.2 million people in the United States suffer from an abdominal aortic aneurysm. Aneurysm rupture is the nation's 13th leading cause of death. Surgeons perform approximately 65,000 abdominal aortic aneurysm repairs annually.
However, in a surgical repair procedure called endovascular aneurysm repair, one of every six patients experiences stent-graft leakage from traditional stent-grafts in the month following surgery. Additionally, 20 to 30 percent of patients require additional corrective surgery as much as six to eight years later.
While pursuing her doctoral degree in biomedical engineering at UTSA under the supervision of Agrawal and Bailey, Kaufmann developed a unique scaffold, which promotes tissue formation. The product, called a tissue-engineering scaffold for aneurysm repair (TESAR), creates a tissue barrier between the blood and the aneurysm after it is implanted.
The scaffold promotes healthy tissue formation to repave the aneurysm wall. Once the scaffold is in place, the aneurysm stops expanding and the risk of rupture decreases. After new tissue is in place, the scaffold degrades and is safely reabsorbed by the body.
Cardiovate's TESAR stent-graft has been shown in the laboratory to reduce post-operative complications during aneurysm repair surgery such as the need for additional corrective surgeries following the initial procedure. Also, the natural tissue is a better match for biological healing than the materials found in traditional stent-grafts.
Between now and March 2013, Kaufmann, Agrawal and Bailey will work together to refine the manufacturing of the TESAR, and they will test it to ensure it conforms to the highest safety and quality standards.
"The launch of Cardiovate is testament to the phenomenal technology being created in UTSA labs and the great entrepreneurial ecosystem the university fosters," said Cory Hallam, director of the UTSA Center for Innovation and Technology Entrepreneurship. "These types of spin-offs have the ability to save lives, create jobs, build multi-million-dollar markets and significantly reduce health-care costs caused by complications that arise with the existing technologies."
The scholars expect to make the product available for licensing to a larger company in 2013. Ideally, it then would be on the market for vascular surgeons to use shortly after being evaluated by the FDA.
The annual UTSA Graduate fair gives students an opportunity to meet representatives who can provide the information on admission requirements, fellowship opportunities, and other key information.
University Center, Main Campus
A recruiter will speak to potential candidates for the Archer program. The Archer program has helped students land successful careers in public service.
Durango Building (DB 2.208), Downtown Campus
Canadian scholar Jasmin Hristov will present a lecture on paramilitarism, complex type of politically-motivated violence in different parts of Latin America. This presentation will explain paramilitary violence as a tool of economic globalization.
Buena Vista St. Bldg., Aula Canaria Lecture Hall (BV 1.328), Downtown Campus
Richard Peretz,’85, chief financial officer at UPS, will present the keynote address at the Frost Distinguished Lecture Series, presented by the UTSA College of Business.
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The UTSA Department of Philosophy and Classics hosts Michael Wheeler from University of Stirling as its Brackenridge Distinguished Visiting Professor. He will be giving a talk on how creativity works.
H-E-B University Center (HUC 1.102), Main Campus,
The Dept. of Kinesiology, Health and Nutrition and the South Texas Consortium for HIV and STI Research welcomes Dr. Joshua Rosenberger who will discuss his recent work on using innovative HIV-prevention strategies.
University Center (UC 2.02.12), Main Campus
Join the UTSA African American Studies program for a lecture by Gary Bledsoe, President of the Texas NAACP, who specializes in public interest law, employment and civil rights law.
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The UTSA College of Engineering Technology Symposium showcases innovative student projects and research performed across multiple disciplines including engineering, science and business. The public is invited.
H-E-B UC Ballroom (HUC 1.104), Main Campus
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