UTSA alumna, advisers launch Cardiovate to prevent aortic aneurysm ruptures
(May 23, 2012) ---University of Texas at San Antonio (UTSA) alumna Jordan Kaufmann, Ph.D.; UTSA College of Engineering Dean Mauli Agrawal; and UT Medicine San Antonio cardiologist Steven Bailey, M.D., have launched Cardiovate, a technology start-up that will offer a new and much-needed cardiovascular stent-graft to prevent aneurysm leakage following cardiovascular surgeries.
Kaufmann, an alumna of the UTSA College of Engineering's Department of Biomedical Engineering, developed the stent-graft as part of her doctoral research with UTSA's Agrawal and Bailey, division chief for cardiology in the School of Medicine of the UT Health Science Center San Antonio.
"To take an idea that we were throwing around and develop it all the way to a product for a start-up company has been an incredible opportunity," said Kaufmann. "The path epitomized both translational research and multidisciplinary studies, which has been a great educational experience."
Approximately 1.2 million people in the United States suffer from an abdominal aortic aneurysm. Aneurysm rupture is the nation's 13th leading cause of death. Surgeons perform approximately 65,000 abdominal aortic aneurysm repairs annually.
However, in a surgical repair procedure called endovascular aneurysm repair, one of every six patients experiences stent-graft leakage from traditional stent-grafts in the month following surgery. Additionally, 20 to 30 percent of patients require additional corrective surgery as much as six to eight years later.
While pursuing her doctoral degree in biomedical engineering at UTSA under the supervision of Agrawal and Bailey, Kaufmann developed a unique scaffold, which promotes tissue formation. The product, called a tissue-engineering scaffold for aneurysm repair (TESAR), creates a tissue barrier between the blood and the aneurysm after it is implanted.
The scaffold promotes healthy tissue formation to repave the aneurysm wall. Once the scaffold is in place, the aneurysm stops expanding and the risk of rupture decreases. After new tissue is in place, the scaffold degrades and is safely reabsorbed by the body.
Cardiovate's TESAR stent-graft has been shown in the laboratory to reduce post-operative complications during aneurysm repair surgery such as the need for additional corrective surgeries following the initial procedure. Also, the natural tissue is a better match for biological healing than the materials found in traditional stent-grafts.
Between now and March 2013, Kaufmann, Agrawal and Bailey will work together to refine the manufacturing of the TESAR, and they will test it to ensure it conforms to the highest safety and quality standards.
"The launch of Cardiovate is testament to the phenomenal technology being created in UTSA labs and the great entrepreneurial ecosystem the university fosters," said Cory Hallam, director of the UTSA Center for Innovation and Technology Entrepreneurship. "These types of spin-offs have the ability to save lives, create jobs, build multi-million-dollar markets and significantly reduce health-care costs caused by complications that arise with the existing technologies."
The scholars expect to make the product available for licensing to a larger company in 2013. Ideally, it then would be on the market for vascular surgeons to use shortly after being evaluated by the FDA.
The NSA Codebreaker Challenge provides students with a hands-on opportunity to develop their reverse-engineering, low-level code analysis skills while working on a realistic problem set centered around the NSA’s mission. Developer Eric Bryant will present a Tech Talk and answer questions about the challenge. Doors open at 2:30 p.m. Free pizza. Open to all.John Peace Library (JPL 4.04.22), Main Campus
UTSA's Office of Sustainability hosts a full day of activities to celebrate the opening of the Tito Bradshaw Bicycle Repair Shop. A ribbon-cutting at 6 p.m.will include President Eighmy, Mayor Nirenberg, Councilman Pelaez and Councilwoman Gonzales.Ximenes Ave. between Ximenes Ave. Lot and Brackenridge Ave. Lot 1, Main Campus
Annual symposium to highlight the importance of effective translation and interpreting in our global community.H-E-B Student Union Travis Room (HSU 2.202), Main Campus
The UTSA Institute for Law and Public Affairs and the Southwest Association of Prelaw Advisors will host the annual Law School Fair for students interested in attending law school. Attendees will have the opportunity to meet with representatives from approximately 90 ABA approved law schools (including all law schools in Texas), and learn about admissions, financing, course offerings, student life, program reputation, with the opportunity to gain application fee waivers.H-E-B Student Union, Ballroom (HSU 1.104), Main Campus
This event will showcase the new Large-Scale Testing Laboratory, built to serve students and researchers in UTSA's Department of Civil and Environmental Engineering. The Grand Opening will feature speakers, a live demonstration, and tours.Large Scale Testing Laboratory, Main Campus
To prepare, graduation candidates should attend to obtain important information about the ceremony and life after UTSA. At the event, they can order their ceremonial cap and gown and other Commencement-related items as well as win prizes and capture lasting memories with fellow Roadrunners at a selfie station. UTSA ID Card required; no reservation needed.Buena Vista Street Building, Meeting Assembly Room (BVB 1.338), Downtown Campus
To prepare, graduation candidates should attend to obtain important information about the ceremony and life after UTSA. At the event, they can order their ceremonial cap and gown and other Commencement-related items as well as win prizes and capture lasting memories with fellow Roadrunners at a selfie station. UTSA ID Card required; no reservation needed.H-E-B Student Union, Ballrooms (HSU 1.104 and 1.106), Main Campus