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UTSA alumna, advisers launch Cardiovate to prevent aortic aneurysm ruptures

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Cardiovate device

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(May 23, 2012) ---University of Texas at San Antonio (UTSA) alumna Jordan Kaufmann, Ph.D.; UTSA College of Engineering Dean Mauli Agrawal; and UT Medicine San Antonio cardiologist Steven Bailey, M.D., have launched Cardiovate, a technology start-up that will offer a new and much-needed cardiovascular stent-graft to prevent aneurysm leakage following cardiovascular surgeries.

Kaufmann, an alumna of the UTSA College of Engineering's Department of Biomedical Engineering, developed the stent-graft as part of her doctoral research with UTSA's Agrawal and Bailey, division chief for cardiology in the School of Medicine of the UT Health Science Center San Antonio.

"To take an idea that we were throwing around and develop it all the way to a product for a start-up company has been an incredible opportunity," said Kaufmann. "The path epitomized both translational research and multidisciplinary studies, which has been a great educational experience."

Approximately 1.2 million people in the United States suffer from an abdominal aortic aneurysm. Aneurysm rupture is the nation's 13th leading cause of death. Surgeons perform approximately 65,000 abdominal aortic aneurysm repairs annually.

However, in a surgical repair procedure called endovascular aneurysm repair, one of every six patients experiences stent-graft leakage from traditional stent-grafts in the month following surgery. Additionally, 20 to 30 percent of patients require additional corrective surgery as much as six to eight years later.

While pursuing her doctoral degree in biomedical engineering at UTSA under the supervision of Agrawal and Bailey, Kaufmann developed a unique scaffold, which promotes tissue formation. The product, called a tissue-engineering scaffold for aneurysm repair (TESAR), creates a tissue barrier between the blood and the aneurysm after it is implanted.

The scaffold promotes healthy tissue formation to repave the aneurysm wall. Once the scaffold is in place, the aneurysm stops expanding and the risk of rupture decreases. After new tissue is in place, the scaffold degrades and is safely reabsorbed by the body.

Cardiovate's TESAR stent-graft has been shown in the laboratory to reduce post-operative complications during aneurysm repair surgery such as the need for additional corrective surgeries following the initial procedure. Also, the natural tissue is a better match for biological healing than the materials found in traditional stent-grafts.

Between now and March 2013, Kaufmann, Agrawal and Bailey will work together to refine the manufacturing of the TESAR, and they will test it to ensure it conforms to the highest safety and quality standards.

"The launch of Cardiovate is testament to the phenomenal technology being created in UTSA labs and the great entrepreneurial ecosystem the university fosters," said Cory Hallam, director of the UTSA Center for Innovation and Technology Entrepreneurship. "These types of spin-offs have the ability to save lives, create jobs, build multi-million-dollar markets and significantly reduce health-care costs caused by complications that arise with the existing technologies."

The scholars expect to make the product available for licensing to a larger company in 2013. Ideally, it then would be on the market for vascular surgeons to use shortly after being evaluated by the FDA.

 

 

Events

Tuesday, May 3, 5 p.m.

Henry B. Gonzalez Centennial Tribute

The College of Public Policy and the Office for Community Services present a 100th anniversary salute to the late Congressman Henry B. Gonzalez. A distinguished panel will discuss Gonzalez's historical impact. Free and open to the public.
Aula Canaria Lecture Hall (BV 1.328) , Downtown Campus

Wednesday, May 4, 5 p.m.

School Psychology Symposium and Reception

Student posters will present case studies based on practicum experiences, literature reviews on topics relevant to educational psychology, and other research experiences this year. The event is free and open to the public.
Durango Building (1.124), Downtown Campus

Thursday, May 5, 5 p.m.

String Project Spring Concert

This end-of-semester concert will feature the 3rd through 8th grade students who have participated in the UTSA String Project this year. The event is free and open to the public.
Buena Vista Theater, Downtown Campus

Monday, May 9, 8 a.m.

The Honeynet Project Workshop

This three-day event will focus on the tools, tactics and motives involved in computer and network attacks. Attendees from around the world will take part in world-class hands-on trainings and technical discussions.
H-E-B University Center Ballroom, Main Campus

Thursday, May 12, 4 p.m.

Master of Public Administration Open House

Visit with faculty, alumni and students to discuss the benefits of and requirements for a Master Degree in Public Administration and/or the Graduate Certificate in Nonprofit Administration & Leadership
Buena Vista Building (1.338), Downtown Campus

Saturday, May 14, 10 a.m.

UTSA Spring Commencement: Ceremony One

UTSA Spring Commencement ceremony for the College of Architecture, Construction and Planning, the College of Education and Human Development and the College of Sciences.
Alamodome

Saturday, May 14, 4 p.m.

UTSA Spring Commencement: Ceremony Two

UTSA Spring Commencement ceremony for the College of Business, the College of Public Policy and University College.
Alamodome

Sunday, May 15, 2 p.m.

UTSA Spring Commencement: Ceremony Three

UTSA Spring Commencement ceremony for the College of Engineering and the College of Liberal and Fine Arts.
Alamodome

Wednesday, May 18, 3 p.m.

The Great Staff Appreciation Event

The UTSA community is invited to honor the roughly 2,600 UTSA staff members who contribute to the success of the university and its students.
University Center Ballroom, Main Campus

Thursday, May 19, 6 p.m.

Superintendent Certification Program Information Session

Join UTSA faculty and staff, current students, and area central office administrators/program alumni to learn about this exciting accelerated and web-enhanced program leading to Texas Superintendent Certification. The event is free and open to the public.
Buena Vista Building (1.322), Downtown Campus


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