Tuesday, October 13, 2015


UTSA research confirms epigenetic reprogramming occurs naturally in mice


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(July 2, 2012) -- In collaboration with scholars at the University of Hawaii at Honolulu and the University of Pennsylvania School of Medicine, researchers from The University of Texas at San Antonio Department of Biology have demonstrated in the laboratory for the first time that primary epigenetic mutations are corrected in the germ (sperm and egg) cells of mice.

The findings are critical because they confirm that environmental factors such as those involved in assisted reproductive technologies (ART) such as in vitro fertilization are likely to induce epimutations, but that these defects are subsequently corrected in the germ cells of the individuals produced by ART and so are not transmitted to subsequent generations.

The epigenome is the genetic programming that is responsible for gene expression, which ultimately decides one's outward appearance. Epimutations typically lead to changes in appearance or cellular function when they disrupt the normal function of one or more genes in a cell.

Over six years, UTSA scholar John McCarrey, the Robert and Helen Kleberg Distinguished Chair in Cellular and Molecular Biology, and two of his graduate students, Eric de Waal and Puraskar Ingale, studied three genes in mice artificially derived through a process called intracytoplasmic sperm injection (ICSI). They observed that half of these mice exhibited epigenetic mutations in their somatic cells.

Previous anecdotal observations had suggested that ICSI-derived mice do not pass on epimutations to their naturally conceived offspring. McCarrey and his collaborators wanted to find definitive evidence confirming this notion.

When the researchers allowed ICSI-derived mice that had epimutations in their somatic cells to breed naturally, they observed that the offspring had no epimuations. Their findings demonstrate that the epigenomes of the parent mice were reprogrammed at some point during the natural reproduction process.

Taken together, the science suggests that ART methods can cause epigenetic defects (epimutations) in the individuals produced by this method, but that if these individuals then reproduce naturally, their offspring will not display similar defects.

"The epigenome is made up of reversible modifications of genetic information, and these modifications are highly susceptible to environmental influences," said McCarrey. "There are more than 4 million humans alive today who were conceived by various forms of ART, and these individuals are at risk of having incurred epimutations during the ART process. The good news is that our data suggest that if these individuals reproduce naturally, their children are not likely to inherit these epigenetic defects."

Assisted reproductive technologies (ART) are becoming increasingly common worldwide and now account for two to three percent of human births. McCarrey and his team are continuing their research in an attempt to optimize ART methods so as to minimize the occurrence of epimutations in these individuals.



Oct. 14, 5:30 p.m.

Architecture as Rendered Society

The UTSA College of Architecture, Construction and Planning, in partnership with AIA San Antonio’s Latinos in Architecture, presents architect Andrés Jaque, founder of the Office for Political Innovation, an architectural practice dually based in New York and Madrid.
Buena Vista Building, Aula Canaria Lecture Hall (BV 1.328), Downtown Campus

Oct. 15, 6 p.m.

Take Back the Night 2015

The UTSA Women’s Studies Institute invites you to Take Back the Night, an international initiative to raise awareness and empower survivors while educating allies through a march, poetry, and testimonios. This is a gender-inclusive movement to shatter the silence surrounding sexual and domestic violence.
Sombrilla Plaza, Main Campus

Oct. 19, 10 a.m.-6 p.m.

UTSA Grad Fest Fall 2015

Grad Fest is an event designed to prepare you for commencement while celebrating your achievement. You will have the opportunity to purchase commencement regalia, order class rings, diploma frames, explore graduate school opportunities, learn about successful Stafford loan repayment and discuss career outcomes.
H-E-B University Center Ballroom, Main Campus

Oct. 20, 10 a.m.-3 p.m.

UTSA Grad Fest Fall 2015

Grad Fest is an event designed to prepare you for commencement while celebrating your achievement. You will have the opportunity to purchase commencement regalia, order class rings, diploma frames, explore graduate school opportunities, learn about successful Stafford loan repayment and discuss career outcomes.
H-E-B University Center Ballroom, Main Campus

Oct. 20-21, 9 a.m. - 3 p.m.

SECC Book Sale

Looking for a good read? Shop for yourself or for gifts and help change a life at the same time. Browse and buy children’s stories, novels and more at the 2015 SECC Book Sale.
Sombrilla Plaza, Main Campus

Oct. 21, 7-8:30 p.m.

Texas Water Symposium

The Texas Water Symposium will take a close look at the SAWS/Vista Ridge pipeline project. The program will feature a conversation about the regional, financial and ecological considerations of the 142-mile pipeline. The event is free and open to the public.
Main Building (MB 0.106), Main Campus

Oct. 22, 6 p.m.

Phi Kappa Phi Last Lecture

What would Dr. John Bartkowski say if it were his last lecture? The UTSA professor of sociology will speak about “The Power of Listening” in this annual event sponsored by the UTSA chapter of Phi Kappa Phi. A reception will follow.
Denman Room (UC 2.201.28), Main Campus

Oct. 27, 11:30 a.m.

Lecture by Composer Larry Groupe

The UTSA Music Department presents Emmy-award winning Composer Larry Groupe. Groupe has composed music for films such as "The Contender," "Straw Dogs" and "Miami Vice," and TV shows such as "Star Trek: The Next Generation," "Ren and Stimpy" and "American Gladiators." Lecture is free and open to the public.
Arts Building (ART 2.03.15-18), Main Campus

Oct. 29, 5:30 p.m.

White Bound: Nationalists, Anti-Racists and the Shared Meanings of Race

The Dean's Distinguished Lecture Series continues with Dr. Matthew Hughey, a scholar of race, racism and racial inequality.
Buena Vista Building (BV 1.328), Downtown Campus

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Did You Know?

UTSA writes the book on all-digital libraries

As touch screens and e-books demand more and more attention from both casual readers and scholars, many people say the handwriting is on the wall for the printed page.

At UTSA, the handwriting is on the wall for a library that doesn't have any printed books.

Since March 2010, the bookless library in the Applied Engineering and Technology Building has given UTSA students an innovative way to read, research and work with each other to solve problems.

With ultra-modern furniture and a décor featuring desktop computers, scanners and LCD screens, the AET Library is designed to engage students in an online format. But it also offers group study niches and study rooms with whiteboards and glass walls on which students can write. The space encourages teamwork, communications and problem solving for the next generation of scientists and professional engineers.

Did you know? The UTSA AET Library is the nation's first completely bookless library on a college or university campus. It served as a model for Bexar County's first-in-the-nation public bookless library system and one of its branches, the Dr. Ricardo Romo BiblioTech.

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