Tuesday, August 04, 2015

UTSA research confirms epigenetic reprogramming occurs naturally in mice

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(July 2, 2012) -- In collaboration with scholars at the University of Hawaii at Honolulu and the University of Pennsylvania School of Medicine, researchers from The University of Texas at San Antonio Department of Biology have demonstrated in the laboratory for the first time that primary epigenetic mutations are corrected in the germ (sperm and egg) cells of mice.

The findings are critical because they confirm that environmental factors such as those involved in assisted reproductive technologies (ART) such as in vitro fertilization are likely to induce epimutations, but that these defects are subsequently corrected in the germ cells of the individuals produced by ART and so are not transmitted to subsequent generations.

The epigenome is the genetic programming that is responsible for gene expression, which ultimately decides one's outward appearance. Epimutations typically lead to changes in appearance or cellular function when they disrupt the normal function of one or more genes in a cell.

Over six years, UTSA scholar John McCarrey, the Robert and Helen Kleberg Distinguished Chair in Cellular and Molecular Biology, and two of his graduate students, Eric de Waal and Puraskar Ingale, studied three genes in mice artificially derived through a process called intracytoplasmic sperm injection (ICSI). They observed that half of these mice exhibited epigenetic mutations in their somatic cells.

Previous anecdotal observations had suggested that ICSI-derived mice do not pass on epimutations to their naturally conceived offspring. McCarrey and his collaborators wanted to find definitive evidence confirming this notion.

When the researchers allowed ICSI-derived mice that had epimutations in their somatic cells to breed naturally, they observed that the offspring had no epimuations. Their findings demonstrate that the epigenomes of the parent mice were reprogrammed at some point during the natural reproduction process.

Taken together, the science suggests that ART methods can cause epigenetic defects (epimutations) in the individuals produced by this method, but that if these individuals then reproduce naturally, their offspring will not display similar defects.

"The epigenome is made up of reversible modifications of genetic information, and these modifications are highly susceptible to environmental influences," said McCarrey. "There are more than 4 million humans alive today who were conceived by various forms of ART, and these individuals are at risk of having incurred epimutations during the ART process. The good news is that our data suggest that if these individuals reproduce naturally, their children are not likely to inherit these epigenetic defects."

Assisted reproductive technologies (ART) are becoming increasingly common worldwide and now account for two to three percent of human births. McCarrey and his team are continuing their research in an attempt to optimize ART methods so as to minimize the occurrence of epimutations in these individuals.

 

 

Did You Know?

For acclaimed UTSA writer, poetry rhymes with life

Robert Penn Warren said: “How do poems grow? They grow out of your life.” That is certainly true for Carmen Tafolla. An associate professor of practice with the UTSA College of Education and Human Development, Tafolla has authored more than 20 acclaimed books of poetry and prose, including "The Holy Tortilla and a Pot of Beans." It won the Tom´s Rivera Children’s Book Award in 2009.

Tafolla is a San Antonio native who grew up on the West Side. Attending a private high school, she realized that the literature did not positively portray her community or the people who lived there. She determined to change that in her writing. In published works for both adults and children — more than 200 anthologies, magazines, journals, textbooks and readers in four languages — Tafolla reflects on the rich Mexican-American culture of San Antonio in which she grew up.

Did you know? Tafolla was San Antonio's first Poet Laureate, from 2012 to 2014, and currently serves as the Poet Laureate of Texas.

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Aug. 4, 6 - 8 p.m.

Free Teacher Tuesday: Los Tejanos Workshop

Discover resources and strategies for teaching Tejano history and culture and get a special educator's tour of the new long-term exhibit, Los Tejanos.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 6, 5 - 7 p.m.; 9 a.m. - 3:30 p.m.

6th Annual Texas Higher Education Symposium

This annual symposium is an opportunity to discuss Texas higher education issues and trends with Texas higher education scholars, state and local government officials, students, and campus and local community members.
Downtown Campus

Aug. 9, 12 - 5 p.m.

Vaquerocation 2015

This cowboy-themed programming, offered in conjunction with Our Kids Magazine's Kidcation Week, gives families the opportunity to visit with cowboy docents, enjoy readings and visit activity tables.
Institute of Texan Cultures, 801 E. Cesar E. Chavez Blvd.

Aug. 17, 11:30 p.m.

Midnight Light

Join President Ricardo Romo, The Spirit of San Antonio Marching Band, students, faculty and staff to light the monument at the Main Campus entrance at the stroke of midnight.
John Peace Boulevard Entrance, Main Campus

Aug. 18, 11 a.m. - 1 p.m.

President's BBQ on the Plaza

Join university President Ricardo Romo on the Bill Miller Plaza for his annual free BBQ lunch.
Bill Miller Plaza, Downtown Campus

Aug. 18, 5:30 p.m. - 7:30 p.m.

President's BBQ on the Lawn

Join university President Ricardo Romo on the Convocation Center lawn for his annual free BBQ lunch.
Convocation Center East Lawn, Main Campus

Aug. 22, 6 p.m.

UTSA Alumni Gala

The UTSA Alumni Association hosts this annual gala honoring the Alumna of the Year, Alumnus of the Year and the Alumnus of the Year Lifetime Achievement award winners.
Hyatt Regency Hill Country Resort & Spa, 9800 Hyatt Resort Dr.


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UTSA student contemplates life, love in new book

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