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UTSA research confirms epigenetic reprogramming occurs naturally in mice

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(July 2, 2012) -- In collaboration with scholars at the University of Hawaii at Honolulu and the University of Pennsylvania School of Medicine, researchers from The University of Texas at San Antonio Department of Biology have demonstrated in the laboratory for the first time that primary epigenetic mutations are corrected in the germ (sperm and egg) cells of mice.

The findings are critical because they confirm that environmental factors such as those involved in assisted reproductive technologies (ART) such as in vitro fertilization are likely to induce epimutations, but that these defects are subsequently corrected in the germ cells of the individuals produced by ART and so are not transmitted to subsequent generations.

The epigenome is the genetic programming that is responsible for gene expression, which ultimately decides one's outward appearance. Epimutations typically lead to changes in appearance or cellular function when they disrupt the normal function of one or more genes in a cell.

Over six years, UTSA scholar John McCarrey, the Robert and Helen Kleberg Distinguished Chair in Cellular and Molecular Biology, and two of his graduate students, Eric de Waal and Puraskar Ingale, studied three genes in mice artificially derived through a process called intracytoplasmic sperm injection (ICSI). They observed that half of these mice exhibited epigenetic mutations in their somatic cells.

Previous anecdotal observations had suggested that ICSI-derived mice do not pass on epimutations to their naturally conceived offspring. McCarrey and his collaborators wanted to find definitive evidence confirming this notion.

When the researchers allowed ICSI-derived mice that had epimutations in their somatic cells to breed naturally, they observed that the offspring had no epimuations. Their findings demonstrate that the epigenomes of the parent mice were reprogrammed at some point during the natural reproduction process.

Taken together, the science suggests that ART methods can cause epigenetic defects (epimutations) in the individuals produced by this method, but that if these individuals then reproduce naturally, their offspring will not display similar defects.

"The epigenome is made up of reversible modifications of genetic information, and these modifications are highly susceptible to environmental influences," said McCarrey. "There are more than 4 million humans alive today who were conceived by various forms of ART, and these individuals are at risk of having incurred epimutations during the ART process. The good news is that our data suggest that if these individuals reproduce naturally, their children are not likely to inherit these epigenetic defects."

Assisted reproductive technologies (ART) are becoming increasingly common worldwide and now account for two to three percent of human births. McCarrey and his team are continuing their research in an attempt to optimize ART methods so as to minimize the occurrence of epimutations in these individuals.

 

 

Events
Feb. 13, 10 a.m. - 5 p.m.

29th annual Asian Festival - Year of the Monkey

The UTSA Institute of Texan Cultures invites Texas and Texans to the Asian Festival. What began as a traditional family reunion for the Chinese New Year has expanded to include other Asian communities and participants, showcasing their unique culture and traditions.
The UTSA Institute of Texan Cultures

Feb. 13, 1 p.m.

2016 Interdisciplinary Studies Colloquium

Join the UTSA Department of Interdisciplinary Learning and Teaching in celebrating interdisciplinary inquiry at the 2016  Interdisciplinary Studies Colloquium.  The colloquium will include a panel of faculty and recent doctoral graduate and a showcase of the best IDS undergraduate inquiry projects of the year 2015. The event is free and open to the public.
Business Building (BB 2.06.04), UTSA Main Campus

Feb. 16, 8:30 - 11:30 a.m.

S.T.E.M. Career Fair

Are you looking for career opportunities in Science, Technology, Engineering or Math? Come to the SPRING 2015 STEM Career Fair. Recruiters from across the STEM fields will be present with full-time, part-time and/or internship opportunities. Professional dress is required. Bring plenty of resumes! Download the UTSA Career Fair Plus App on iOS and Android.
Convocation Center, Main Campus

Feb. 16, 1:30 - 4:30 p.m.

Spring 2016 All Majors Career & Internship Fair

Come to the Spring 2016 All Majors and Internship Career Fair. Recruiters from across all industries will be present with full-time or internship opportunities. Professional Dress is Required. Bring plenty of resumes! Download the UTSA Career Fair Plus App on iOS and Android.
Convocation Center, Main Campus

Feb. 17, 5:30 p.m.

CACP Speaker Series continues with Cesar Pelli

The UTSA College of Architecture, Construction and Planning (CACP) welcomes renowned architect Cesar Pelli as part of the CACP’s 2015-16 Speaker Series. Pelli is founder and Senior Principal of the New Haven, Conn. firm Pelli Clarke Pelli Architects. In his talk, “Becoming an Architect,” Pelli will present and discuss projects that were critical steps in his career.
Buena Vista Theater (BV 1.326), Downtown Campus

Feb. 23, 5:30 p.m.

African-American Social Welfare Pioneers Responding to Community Needs

The UTSA College of Public Policy presents the Dean's Distinguished Lecture Series featuring Dr. Iris Carlton-LaNey, Professor of the School of Social Work at the University of North Carolina-Chapel Hill. Dr. Iris Carlton LaNey will speak to the UTSA community about the role and impact of African-Americans in the social work profession.
Buena Vista Theater (BV 1.326), Downtown Campus

Feb. 23, 5:30 p.m.

African-American Social Welfare Pioneers Responding to Community Needs

The UTSA College of Public Policy presents the Dean's Distinguished Lecture Series featuring Dr. Iris Carlton-LaNey, Professor of the School of Social Work at the University of North Carolina-Chapel Hill. Dr. Carlton-LaNey will speak to the UTSA community about the role and impact of African-Americans in the social work profession.
Buena Vista Theater (BV 1.326), Downtown Campus

Feb. 23, 7 p.m.

Presentation and Book Signing with Luis Carlos Montalvan

Please join us for a presentation and book signing by Luis Carlos Montalván (Fmr. Capt., USA), author of the New York Times Bestseller Until Tuesday and the international award-winning childrens book Tuesday Tucks Me In. His books will be available for purchase at the UTSA Bookstore. This event is free and open to the public.
Southwest Room (DB 1.124), Downtown Campus

Feb. 25, 6 p.m.

12th Annual Black Heritage Gala

The 12th Annual Black Heritage Gala is a formal event which includes a student performance, keynote remarks by Michael Brown, an award presentation, dinner and dancing. Tickets are $10 for UTSA students and $15 for all other guests. Tickets are on sale now at Roadrunner Express. Contact (210) 458-4770 for more information.
H-E-B University Center Ballroom, Main Campus

Feb. 27, 9 a.m.

Cultural Contrasts in Latin America

The UTSA Institute of Texan Cultures will host a free workshop focusing on teaching Latin American culture and geography for students seeking their teacher certification. The workshop includes free resources for teaching Latin American subject matter as well as presentations on language, identity, music, geography, and political and developmental history, and a special educators’ tour of the museum’s Los Tejanos exhibit. Free with registration.
The UTSA Institute of Texan Cultures (ITC 3.01.02)


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