Tuesday, October 06, 2015


UTSA scholar researches safety of common in-vitro fertilization modes


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(Sept. 24, 2012) -- In collaboration with scholars at the University of Hawaii and the University of Pennsylvania School of Medicine, a group of researchers led by John McCarrey, the UTSA College of Sciences' Kleberg Distinguished Chair in Cellular and Molecular Biology, and his graduate student Eric de Waal, who recently received his Ph.D. degree from UTSA, have demonstrated that the hormones known as gonadotropins lead to an increase in epimutations in mice produced in vitro.

The findings are important because they call into question the safety of the methods that are commonly used when couples use the in vitro fertilization process to have children.

The epigenome is the mechanism that programs the genome to control gene expression in each type of cell, and this ultimately decides one's outward appearance and influences development. Epimutations can lead to changes in appearance, development or cellular function when they disrupt the normal function of one or more genes in a cell.

Assisted reproductive technologies (ART) such as in vitro fertilization are a commonly accepted practice and account for more than four million children born worldwide so far, however caution persists among some scholars who point out that the long-term safety of these methods remains generally unknown. Most of the people conceived with the help of ART are currently still under the age of 35.

To better understand how ART and epimutations are linked, the scholars compared the frequency of epimutations in mice produced through an ART process called intracytoplasmic sperm injection (ICSI). They found the epimutation rate to be elevated in mice produced by this method when compared to that in naturally conceived mice.

Next, they compared the frequency of epimutations in three groups of mice: (1) mice produced by natural conception, (2) ICSI-derived mice and (3) mice derived through a process called somatic cell nuclear transfer (SCNT), also known as "cloning". They expected the epimutation rates in the cloned SCNT-derived mice to be higher than those in the ICSI mice. They were surprised, however, to find that the ICSI-derived mice had a higher rate of epimutations than the SCNT-derived mice.

The scholars then reasoned that since gonadotropin-stimulated eggs were used to produce both the ICSI and SCNT-derived offspring, but the nucleus in the egg used for SCNT was then replaced with another nucleus that had not been stimulated with gonadotropin, the lingering effects of gonadotropin exposure in the ICSI-derived offspring must be related to the higher incidence of epimutations in these mice. To test this idea, they subjected female mice to gonadotropin stimulation and then allowed the mice to reproduce naturally to isolate the effects of gonadotropins.

Ultimately, they found that the offspring produced from females subjected to gonadotropin stimulation displayed the same elevated incidence of epimutations they observed in the mice produced by ICSI, confirming that gonadotropin stimulation is a significant factor in inducing epimuations.

Although the mouse sample size the researchers used was small, McCarrey says the findings warrant some caution about the methods associated with ART and call for additional study to determine if the findings hold true in humans.

"ART now accounts for one to four percent of all births in developed countries, so we must work to make this process as completely safe as possible" said McCarrey. "Our results suggest that gonadotropin stimulation, which is typically used in every ART procedure, contributes to the formation of epimutations in the offspring produced. We want to understand why this happens, how it happens and what long-term effects this causes."

The research is available in Human Molecular Genetics.



Oct. 5, 6 p.m.

Film Screening: The Head of Joaquin Murrieta by John Valadez

The Mexican American Studies Program will host a screening of this irreverent, entertaining and often disturbing tale that uses both fiction and documentary story telling devices to tear open a painful and long ignored history: the lynching of Mexican Americans in the southwest.
Buena Vista Building Aula Canaria (BV 1.328), Downtown Campus

Oct. 6, 3 p.m.

State of the University

Join President Ricardo Romo as he gives his address to the UTSA community.
H-E-B University Center Ballroom (UC 1.104), Main Campus

Oct. 7, 6:30 p.m.

The Impact of the 84th Texas Legislative Session on Public Schools: Any Rain in Sight or Are Those Smoke Clouds on the Horizon?

Join the College of Education and Human Development's Center for Educational Leadership, Policy and Professional Development for a discussion about what passed and what didn't in the last legislative session and what it means for Bexar County Public Schools. 
Durango Building Southwest Room (DB 1.124), Main Campus

Oct. 8, 10 a.m.

Graduate Fair

Graduate School representatives from across the country will provide information on options after earning a bachelor's degree. Students, alumni and community members are welcome.
University Center Retama Galleria, Main Campus

Oct. 10, 8:30 a.m. - 3 p.m.

UTSA CITE Technology Entrepreneurship Boot Camp

Kickstart your career as an entrepreneur at The University of Texas at San Antonio’s Center for Innovation, Technology and Entrepreneurship (CITE) Technology Entrepreneurship Boot Camp.
Business Building, Richard S. Liu Auditorium (BB 2.01.02), Main Campus

Oct. 14, 5:30 p.m.

Architecture as Rendered Society

The UTSA College of Architecture, Construction and Planning, in partnership with AIA San Antonio’s Latinos in Architecture, presents architect Andrés Jaque, founder of the Office for Political Innovation, an architectural practice dually based in New York and Madrid.
Buena Vista Building, Aula Canaria Lecture Hall (BV 1.328), Downtown Campus

Oct. 20-21, 9 a.m. - 3 p.m.

SECC Book Sale

Looking for a good read? Shop for yourself or for gifts and help change a life at the same time. Browse and buy children’s stories, novels and more at the 2015 SECC Book Sale.
Sombrilla Plaza, Main Campus

Oct. 27, 11:30 a.m.

Lecture by Composer Larry Groupe

The UTSA Music Department presents Emmy-award winning Composer Larry Groupe. Groupe has composed music for films such as "The Contender," "Straw Dogs" and "Miami Vice," and TV shows such as "Star Trek: The Next Generation," "Ren and Stimpy" and "American Gladiators." Lecture is free and open to the public.
Arts Building (2.03.15-18), Main Campus

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Did You Know?

UTSA writes the book on all-digital libraries

As touch screens and e-books demand more and more attention from both casual readers and scholars, many people say the handwriting is on the wall for the printed page.

At UTSA, the handwriting is on the wall for a library that doesn't have any printed books.

Since March 2010, the bookless library in the Applied Engineering and Technology Building has given UTSA students an innovative way to read, research and work with each other to solve problems.

With ultra-modern furniture and a décor featuring desktop computers, scanners and LCD screens, the AET Library is designed to engage students in an online format. But it also offers group study niches and study rooms with whiteboards and glass walls on which students can write. The space encourages teamwork, communications and problem solving for the next generation of scientists and professional engineers.

Did you know? The UTSA AET Library is the nation's first completely bookless library on a college or university campus. It served as a model for Bexar County's first-in-the-nation public bookless library system and one of its branches, the Dr. Ricardo Romo BiblioTech.

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