(Nov. 29, 2012) -- Radiation and chemotherapy can pack a powerful punch against all kinds of cancers. Those who survive, however, are often left with bad news: Their treatments have rendered them infertile.
A UTSA professor has now demonstrated that it is possible to remove testicular stem cells from a monkey prior to chemotherapy, freeze them and later, after cancer treatments, transplant these cells where they can restart sperm production and restore fertility.
UTSA Assistant Professor Brian Hermann worked in collaboration with researchers at the University of Pittsburgh School of Medicine Magee-Women's Research Institute (MWRI) on a technique that might be used to make male cancer patients fertile using their own spermatogonial stem cells.
"This is a really exciting milestone for this research," said John McCarrey, director of the San Antonio Cellular Therapeutics Institute. "This is the first time that anybody has been able to show the concept works in a primate model, and that is an important step in moving the research forward to clinical trials."
While men facing cancer treatments, which could cause infertility, are able to store their own sperm for future use in the fertility clinic, this is not an option for boys before puberty who are not yet making sperm. But, all pre-pubertal boys have spermatogonial stem cells (SSCs) in their testes, which could be used for transplantation.
The concept of using spermatogonial stem cells to restore fertility was first introduced in the mid-1990s by University of Pennsylvania scholar Ralph L. Brinster. Since that time, scholars have been working to demonstrate the concept is viable.
But, more work is required. The research must overcome a number of hurdles before it can become a common clinical practice.
"This research demonstrates the proof of principle -- that the concept works in primates and has a good chance of working in humans," said Hermann. "We need to better understand the optimal timing of transplantation, how to prepare testicular stem cells for transplantation and make them safe for transplantation, and how to maximize their ability to restart sperm production."
But, it's difficult for researchers to know when clinical trials will begin, since the removal and storage of spermatogonial stem cells currently is a rare practice worldwide.
"There are currently only a handful of clinics around the world that will remove and preserve testicular stem cell samples from pre-pubertal patients, and that limits the availability of candidates," said Hermann. "Until more clinics get on board and save stem cells for patients, we are limited in what we can do to test transplantation in clinical trials."
Hermann joined the UTSA College of Sciences faculty in summer 2011, following a post-doctoral fellowship at MWRI alongside Associate Professor Kyle Orwig. At UTSA, he is continuing to focus his research on basic and translational studies of spermatogonial stem cells to preserve fertility in boys treated for cancer and related diseases.
"For a long time, oncologists have been unable to address the long-term consequences of life-saving chemotherapy and radiation treatments such as infertility," said Hermann. "That is now beginning to change as laboratory research such as this study provides new experimental options for patients facing infertility after cancer."
Hermann's research is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Max and Minnie Tomerlin Voelcker Fund, and UTSA.
Learn more about Hermann's research and read his article "Spermatogonial Stem Cell Transplantation into Rhesus Testes Regenerates Spermatogenesis Producing Functional Sperm" in the current issue of Cell Stem Cell, the nation's leading stem cell journal.
The UTSA East Asia Institute hosts District 8 City Councilman Ron Nirenberg who will discuss his recent trip to China for the 8th annual Sister Cities International forum. He will discuss how these conversations help citizens connect in an increasingly global world to exchange ideas and tackle issues affecting all of us.
University Center, Denman Room (UC 2.01.28), Main Campus
Antonio Petrov, assistant professor in the UTSA College of Architecture, Construction and Planning, invites San Antonio to engage in dialogue to gather a broad understanding of Puro. he symposium, which includes UTSA masters students, will be led by community members who embody the term. It's free and open to the public.
Brick at Blue Star Arts Complex, Bldg. 108, 1414 S. Alamo St., San Antonio
Dr. Gaye Theresa Johnson, associate professor of Chicana and Chicano Studies, and African American Studies, at the University of California at Los Angeles is the guest speaker at this free, open event. Johnson is also the author of "Spaces of Conflict Sounds of Solidarity: Music, Race, and Spacial Entitlement in Los Angeles" and "Futures of Black Radicalism."
University Center, Denman Room (UC 02.01.28), Main Campus
The UTSA Consortium for Social Transformation; African American Studies Program presents guest speaker Dr. Gaye Theresa Johnson, associate professor of Chicana and Chicano Studies, and African American Studies, University of California at Los Angelesand author of "Spaces of Conflict Sounds of Solidarity: Music, Race, and Spacial Entitlement in Los Angeles" and "Futures of Black Radicalism." The event is free and open to the public.
University Center, Denman Room (UC 2.01.28), Main Campus
Grab your friends, family, kids and dog for this annual fun run on the UTSA Main Campus benefititng the UTSA Alumni Association.
Convocation Center, Main Campus
Join the Department of Interdisciplinary Learning and Teaching for the 13th annual Storytelling Festival. The festival will feature keynote speaker Carolina Quiroga-Stultz, a Colombian Storyteller and journalist. This event is free and open to the public.
Main Building, ground floor, Main Campus
The IDS Colloquium showcases the excellent scholarship done by the IDS students in the College of Education and Human Development at UTSA. In addition, this event also honors the legacy of Dr. Marian Martinello.
Business Building, University Room (BB 2.06.04), Main Campus
The Department of Biology and the Be the Match Team will collaborate to engage and educate our students in the importance of a life saving donation through peripheral blood stem cells and a marrow harvest.
UC Paseo and Central Plaza, Main Campus
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
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