(Nov. 29, 2012) -- Radiation and chemotherapy can pack a powerful punch against all kinds of cancers. Those who survive, however, are often left with bad news: Their treatments have rendered them infertile.
A UTSA professor has now demonstrated that it is possible to remove testicular stem cells from a monkey prior to chemotherapy, freeze them and later, after cancer treatments, transplant these cells where they can restart sperm production and restore fertility.
UTSA Assistant Professor Brian Hermann worked in collaboration with researchers at the University of Pittsburgh School of Medicine Magee-Women's Research Institute (MWRI) on a technique that might be used to make male cancer patients fertile using their own spermatogonial stem cells.
"This is a really exciting milestone for this research," said John McCarrey, director of the San Antonio Cellular Therapeutics Institute. "This is the first time that anybody has been able to show the concept works in a primate model, and that is an important step in moving the research forward to clinical trials."
While men facing cancer treatments, which could cause infertility, are able to store their own sperm for future use in the fertility clinic, this is not an option for boys before puberty who are not yet making sperm. But, all pre-pubertal boys have spermatogonial stem cells (SSCs) in their testes, which could be used for transplantation.
The concept of using spermatogonial stem cells to restore fertility was first introduced in the mid-1990s by University of Pennsylvania scholar Ralph L. Brinster. Since that time, scholars have been working to demonstrate the concept is viable.
But, more work is required. The research must overcome a number of hurdles before it can become a common clinical practice.
"This research demonstrates the proof of principle -- that the concept works in primates and has a good chance of working in humans," said Hermann. "We need to better understand the optimal timing of transplantation, how to prepare testicular stem cells for transplantation and make them safe for transplantation, and how to maximize their ability to restart sperm production."
But, it's difficult for researchers to know when clinical trials will begin, since the removal and storage of spermatogonial stem cells currently is a rare practice worldwide.
"There are currently only a handful of clinics around the world that will remove and preserve testicular stem cell samples from pre-pubertal patients, and that limits the availability of candidates," said Hermann. "Until more clinics get on board and save stem cells for patients, we are limited in what we can do to test transplantation in clinical trials."
Hermann joined the UTSA College of Sciences faculty in summer 2011, following a post-doctoral fellowship at MWRI alongside Associate Professor Kyle Orwig. At UTSA, he is continuing to focus his research on basic and translational studies of spermatogonial stem cells to preserve fertility in boys treated for cancer and related diseases.
"For a long time, oncologists have been unable to address the long-term consequences of life-saving chemotherapy and radiation treatments such as infertility," said Hermann. "That is now beginning to change as laboratory research such as this study provides new experimental options for patients facing infertility after cancer."
Hermann's research is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Max and Minnie Tomerlin Voelcker Fund, and UTSA.
Learn more about Hermann's research and read his article "Spermatogonial Stem Cell Transplantation into Rhesus Testes Regenerates Spermatogenesis Producing Functional Sperm" in the current issue of Cell Stem Cell, the nation's leading stem cell journal.
The conference is dedicated to sharing recent knowledge and experiences gained in the area of Big Data by researchers in academia, industry and the government sectors within the areas of business, national security, infrastructure, healthcare and visualization.
H-E-B University Center Ballroom (HUC 1.104), Main Campus
Former National Security Advisor Susan Rice, via webcast, will examine America’s economic, political and security relations with China during CHINA Town Hall, an 80-city live discussion and Q&A on China and Sino-American relations.
Building Building, Richard Liu Auditorium (BB 2.01.02), Main Campus
The African American Studies program proudly presents William "Cruz" Shaw, San Antonio City Councilman and UTSA Alumnus. Event is free and open to the public.
University Center, Retama Auditorium (UC 2.02.02), Main Campus
The graduate fair is an opportunity for the UTSA student body and local San Antonio community to learn about graduate education opportunities. The event is free and open to the public.
H-E-B University Center Ballroom (1.104), Main Campus
President Taylor Eighmy is inviting all UTSA students to "Pizza With The Prez." Come grab a slice of pizza and take the opportunity to introduce yourself to the President. Pizza while supplies last.
Frio Street Building, Food Court Commons Area, Downtown Campus
The UTSA Confucius Institute hosts this lecture series on China's Green Movement with Liu Jianqiang, investigative reporter and former Beijing editor for chinadialogue, and Gary Marcuse, Canadian journalist and documentary filmmaker.
McKinney Humanities Building (MH 2.01.12), Main Campus
President Taylor Eighmy is inviting all UTSA faculty and staff to "Tacos With Taylor." Take the opportunity to introduce yourself to the President at any one of these casual meet and greets.
Biotechnology, Science and Engineering Building atrium, Main Campus
The College of Engineering Student Council and the San Antonio Hispanic Chamber of Commerce host this fun and education event. Erika Camacho is the keynote speaker. Children and families are welcome.
East Campus Parking Lot, Valero Way, Main Campus
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.