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UTSA biomedical engineering student wins $25,000 American Heart Association fellowship

nanosystem

Nanochips combined to make a nanosystem

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(June 17, 2013) --University of Texas at San Antonio biomedical engineering Ph.D. candidate Anand Srinivasan has been awarded a $25,000, one-year doctoral fellowship from the American Heart Association (AHA). This highly competitive fellowship provides significant funding to doctoral students to support research and training in cardiovascular and stroke discoveries.

For nearly four years, Srinivasan has developed and tested a series of prototype nanochips under the guidance of UTSA biomedical engineering assistant professor Anand Ramasubramanian and biology professor Jose Lopez-Ribot in collaboration with the director of science at the U.S. Institute of Surgical Research, Kai P. Leung. Their nanochips aid in high-throughput screening, an automated process that allows researchers to quickly test small molecules against an array of thousands of microbial biofilms.

Supported by the AHA, Srinivasan will develop a new chip-based platform that can be used to test the effectiveness of drug treatments for infective endocarditis, a dangerous bacterial-fungal infection of the heart's inner lining. The research is a challenge because it requires Srinivasan to develop a chip that will facilitate bacterial and fungal co-culture biofilms at a nano scale.

Infective endocarditis is an example of a health care-associated infection (HAI), devastating and even deadly infections caused by microorganisms such as bacteria and fungus. Patients generally acquire HAIs when they receive treatment for other conditions, often as a result of their compromised immune systems. According to the Centers for Disease Control and Prevention, approximately one of every 20 hospitalized patients will contract an HAI.

While the medical community is fighting back against HAIs by testing thousands of microbial biofilm samples from hospital surfaces throughout the world, the process is time consuming and costly. The technology currently in use also is outdated.

"The industry standard process currently in place was developed back in the 1950s and tests only a few hundred samples at a time," said Srinivasan. "Using chip-based, high-throughput technology, we have developed a process that is quicker and cheaper. Just one of our nanochips can test 1,200 samples simultaneously."

"We are fortunate to have Anand work on this project," said Ramasubramanian. "He has shown tremendous dedication, resolve and passion all along in integrating microbiology into chip design and fabrication, which is a big challenge."

Srinivasan has authored seven peer-reviewed journal articles and has been invited to give presentations on his discoveries at several conferences across the country, including the American Society of Microbiology and Biomedical Engineering Society. Most recently, his paper, "A High-Throughput Nano-Biofilm Microarray for Antifungal Drug Discovery," was accepted by mBio, the peer-reviewed journal of the American Society for Microbiology, and was published this month.

>> Learn more about the UTSA Department of Biomedical Engineering.

 

 

Events

Wednesday, May 4, 5 p.m.

School Psychology Symposium and Reception

Student posters will present case studies based on practicum experiences, literature reviews on topics relevant to educational psychology, and other research experiences this year. The event is free and open to the public.
Southwest Room (DB 1.124), Downtown Campus

Thursday, May 5, 5 p.m.

String Project Spring Concert

This end-of-semester concert will feature the 3rd through 8th grade students who have participated in the UTSA String Project this year. The event is free and open to the public.
Buena Vista Theater, Downtown Campus

Friday, May 6, 8 p.m.

First Friday Stargazing

The UTSA Department of Physics and Astronomy, Curtis Vaughan Observatory invites everyone to join them for their monthly stargazing event on top of the Flawn Science Building.
Curtis Vaughan Observatory, Main Campus

Sunday, May 8, 1 p.m.

Accordions Across Culture

May’s Free Second Sunday at the UTSA Institute of Texan Cultures features "Accordions Across Cultures," with performances of Mexican, German and Czech accordion music, a documentary screening and crafts for the kids.
UTSA Institute of Texan Cultures

Monday, May 9, 8 a.m.

The Honeynet Project Workshop

This three-day event will focus on the tools, tactics and motives involved in computer and network attacks. Attendees from around the world will take part in world-class hands-on trainings and technical discussions.
H-E-B University Center Ballroom, Main Campus

Thursday, May 12, 4 p.m.

Master of Public Administration Open House

Visit with faculty, alumni and students to discuss the benefits of and requirements for a Master Degree in Public Administration and/or the Graduate Certificate in Nonprofit Administration & Leadership.
Meeting Assembly Room (BVB 1.338), Downtown Campus

Saturday, May 14, 10 a.m.

UTSA Spring Commencement: Ceremony One

UTSA Spring Commencement ceremony for the College of Architecture, Construction and Planning, the College of Education and Human Development and the College of Sciences.
Alamodome

Saturday, May 14, 4 p.m.

UTSA Spring Commencement: Ceremony Two

UTSA Spring Commencement ceremony for the College of Business, the College of Public Policy and University College.
Alamodome

Sunday, May 15, 2 p.m.

UTSA Spring Commencement: Ceremony Three

UTSA Spring Commencement ceremony for the College of Engineering and the College of Liberal and Fine Arts.
Alamodome

Wednesday, May 18, 3 p.m.

The Great Staff Appreciation Event

The UTSA community is invited to honor the roughly 2,600 UTSA staff members who contribute to the success of the university and its students.
H-E-B University Center Ballroom, Main Campus

Thursday, May 19, 6 p.m.

Superintendent Certification Program Information Session

Join UTSA faculty and staff, current students, and area central office administrators/program alumni to learn about this exciting accelerated and web-enhanced program leading to Texas Superintendent Certification. The event is free and open to the public.
BVB 1.322, Downtown Campus


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