Thursday, September 03, 2015

UTSA, SwRI researchers to develop drug-loaded scaffold for bone grafting

bone x-ray

Bone graft

Share this Story

(July 16, 2013) -- Researchers at The University of Texas at San Antonio and Southwest Research Institute (SwRI) jointly announce they are investing $200,000 in new research aimed at developing a synthetic drug-loaded scaffold to use in bone grafting procedures.

More than three million musculoskeletal procedures are currently performed in the United States each year to repair bone tissue damage from trauma, congenital deformities, bone diseases and the removal of cancerous lesions.

The UTSA-SwRI bone graft substitute would be an improvement on the industry's gold standard, autologous grafting. Autologous grafting, the process of transferring bone grafts from one part of the body to another, is generally successful in particular types of bone grafting. However, challenges arise due to tissue scarcity and surgical complications. Additionally, autologous grafts are not effective in treating large bone defects.

UTSA and SwRI researchers Anson Ong, the USAA Foundation Distinguished Professor in Biomedical Engineering, and Jian Ling, staff engineer at SwRI, will use collagen and hydroxyapatite to create their synthetic scaffold. Natural bone is, in large part, made up of collagen, hydroxyapatite and water.

Their proposed scaffold would have a rigid structural framework with complementary elastic properties, making it an ideal bone substitute to endure the body's tough physiological demands. Additionally, the synthetic bone substitute would be scalable. Clinicians would be able to trim it into any shape to fit large bone defects.

Ong and Ling's unique scaffold also would include drug-microparticles. Those microparticles would release active growth factors in a controlled manner over time, causing stem cells to become bone cells to which the implanted scaffold would fuse.

If successful, the new product would tap the unmet needs of an annual $2.5 billion bone graft market.

Ling has more than 19 years of experience in biomedical research, including the development of collagen- hydroxyapatite composite scaffolds. Ong is an established expert in the field of bone-biomaterial tissue interfaces.

The Connect Program, an annual UTSA-SwRI joint funding initiative, was established in 2010 to stimulate inter-organizations research between UTSA scholars and SwRI investigators in fields such as advanced materials, chemistry and chemical engineering, energy, the environment, security and manufacturing.

 

 

Did You Know?

Football standouts make Roadrunner history

For Ashaad Mabry and Triston Wade, football is not just a passing fancy. Both players were part of the UTSA football program almost from the beginning. When UTSA opens the 2015 season Thursday at Arizona, it will be the first time the Roadrunners take the field without them. But Mabry and Wade will still be playing football; their uniforms will just be a different color.

Mabry, a defensive tackle from San Antonio's MacArthur High School, was an honorable mention All-Conference USA selection his final two seasons as a Roadrunner and second among the team's defensive linemen with 49 tackles last year. Wade, a defensive back from Tyler, was the most decorated player in school history. He was a semifinalist for the 2014 Jim Thorpe Award – for the nation's top defensive back – a three-time all-conference honoree and two-year team captain who set a school record of 293 tackles in his career. Both men had outstanding college careers that allowed them to make UTSA history.

Did you know? Mabry and Wade both agreed to terms as undrafted free agents with the New Orleans Saints and Seattle Seahawks, respectively, becoming the first UTSA players to move to the professional ranks.

Read More »
Events
Sept. 7, All Day

Labor Day Holiday

All campuses will be closed for the Labor Day holiday.
All Campuses

Sept. 9, 5:30 p.m.

Architecture Connects

The UTSA College of Architecture, Construction and Planning’s 2015-16 Speaker Series begins Sept. 9 with Toshiko Mori, the Robert P. Hubbard Professor in the Practice of Architecture at the Harvard University Graduate School of Design and principal of Manhattan-based Toshiko Mori Architect.
Buena Vista Building Aula Canaria (BV 1.328), Downtown Campus

Sept. 12, 11 a.m.

UTSA Football vs. Kansas State

Cheer on the UTSA Roadrunners at their home-opener against the Kansas State Wildcats.
Alamodome, 100 Montana St.

Sept. 15, 5:30 - 7 p.m.

Changing the Conversation: Recovery Works!

As part of National Recovery Month, a panel of substance abuse practitioners and members of the recovery community will discuss issues related to substance abuse treatment and recovery.
Durango Building 1.124 (DB 1.124), Downtown Campus

Sept. 24, 6 p.m.

The Power of Story in the Landscape of Memory and Identity

The UTSA College of Education and Human Development will host award-winning children’s author and illustrator Yuyi Morales. Morales will share personal stories that have influenced her work as an author and illustrator.
Buena Vista Building Aula Canaria (BV 1.328), Downtown Campus

Oct. 5, 9 a.m. - 3 p.m.

Civic Engagement Summit

This summit is an opportunity to showcase and share the variety of community engagement activities of UTSA students, faculty, and staff. The summit is currently accepting proposals for poster presentations. The Call for Posters deadline is Friday, Sept. 11.
University Center Denman Room (2.01.28), Main Campus


Other Calendars
» UTSA Events | » Academic | » Institute of Texan Cultures

Submit an Event


Meet a Roadrunner

Teja Guda '08 is an engineer on the cutting edge

Biomedical engineering alum and professor is working to regenerate tissue

UTSA's Mission

The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.

UTSA's Vision

To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.

UTSA's Core Values

We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.

Connect with UTSA News

       


Related Links

Back to Top

2015 © The University of Texas at San Antonio  |  Produced by University Communications and Marketing