(Sept. 23, 2014) -- Karl Klose, professor of biology and a researcher in UTSA's South Texas Center for Emerging Infectious Diseases, has teamed up with researchers at Ruhr University in Bochum, Germany, to understand how humans get infected with cholera. Their findings were released this week in an article published by the Proceedings of the National Academy of Sciences.
Cholera is an acute infection caused by ingestion of food or water that is contaminated with the bacterium Vibrio cholerae. An estimated three to five million cases are reported annually and 100,000-120,000 people die from cholera infections every year. Cholera patients suffer from dramatic fluid loss and can lose up to 40 liters of fluid from their body in just a few days.
Klose and his collaborators discovered that Vibrio cholerae, which normally lives in oceans and rivers, senses a shift in temperature as it enters the human body through a mechanism called a Ribonucleic Acid (RNA) thermometer. The thermometer detects the higher body temperature of 98.6 degrees Fahrenheit, and then turns on the virulence factors that lead to cholera.
Klose's laboratory showed that interfering with the thermometer prevents the bacteria from causing disease, suggesting possible therapeutic outcomes from this research. The research collaboration stemmed from a long friendship between Klose and Franz Narberhaus, who trained as microbiologists together at U.C. Berkeley 25 years ago.
"The temperature shift is one of the signals that the bacterium uses to turn on the virulence factors, such as the cholera toxin, that cause the disease," said Klose. "We have shown that the bacteria's thermometer controls temperature-dependent expression of the virulence factors. They only express them when they are at body temperature and not at ocean temperature."
"We found that if the RNA thermometer is prevented from working correctly and detecting the right temperature, the bacteria won't cause any disease at all. The organisms will just pass right through the body," explained Klose. "If you can figure out how to disrupt the RNA thermometer in some manner, then you may have a therapy against this disease."
Klose says the long-term goal is to come up with intervention strategies against cholera. Understanding exactly how the bacterium controls the expression of the virulence factors is one step forward in trying to intervene during cholera epidemics.
Orientation marks a major step toward becoming a Roadrunner. It is a unique experience designed to welcome freshmen and transfers to UTSA and ensure a successful transition into college. They will learn about UTSA, prepare for their first semester and have fun meeting other students. There is also a special Family Orientation program too.
Various locations, Main and Downtown Campuses
Come out and meet Dr. Ray Bateman, ARL South Cyber on-site Lead, and Kristin Schweitzer who form the nucleus of ARL South Cyber on our campus. They will give a brief overview of the Army Research Laboratory (ARL) and how it fits within the Army’s hierarchy. Morning session is 11 a.m. to 12 p.m. Afternoon session is 2 p.m. to 3 p.m.
John Peace Library (JPL 4.04.12C), Main Campus
Join the UTSA Master of Social Work Advanced Social Work Methods Policy Practice Advocacy Class for a panel discussion on child care policies and its effect on higher education. Event is free and open to the public. Doors open at 6:30 p.m.
Buena Vista Street Building (BVB 1.322), Downtown Campus
UTSA Associate Dean/Associate Professor Francine Romero will sit down with San Antonio Mayor Ron Nirenberg for a wide-ranging conversation about the Mayor's vision for the City's future. Seating is at capacity but the San Antonio Express-News will stream it live.
Buena Vista Street Building Theater (BVB 1.326), Downtown Campus
The sympoisum will focus on the interface between aging and neurodegenerative diseases, will educate the wider research community about advancements in this fast-paced field and stimulate collaborative research in this area. Register online for this free event.
H-E-B University Center Ballroom (HUC 1.106), Main Campus
The 23rd International Conference on Historical Linguistics is offering four special panels open and free to the San Antonio public July 31-Aug. 3 to mark the tricentennial next year. The event is co-sponsored by UTSA Research.
Hotel Contessa, 306 W. Market St., San Antonio
The UTSA community welcomes students to their on-campus home! Laurel Village, Chaparral Village and Alvarez Hall are home for 2,300 students during the academic year, and Move-In event kicks off the start of Roadrunner Days.
Laurel Village, Chaparral Village, Alvarez Hall, Main Campus
The College of Engineering hosts this seminar featuring Jeff Adams, Southwest Zone Quality Manager, Siemens Building Technologies Division. The event is free and open to the public.
Engineering Building (EB 3.04.30), Main Campus
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