(Sept. 23, 2014) -- Karl Klose, professor of biology and a researcher in UTSA's South Texas Center for Emerging Infectious Diseases, has teamed up with researchers at Ruhr University in Bochum, Germany, to understand how humans get infected with cholera. Their findings were released this week in an article published by the Proceedings of the National Academy of Sciences.
Cholera is an acute infection caused by ingestion of food or water that is contaminated with the bacterium Vibrio cholerae. An estimated three to five million cases are reported annually and 100,000-120,000 people die from cholera infections every year. Cholera patients suffer from dramatic fluid loss and can lose up to 40 liters of fluid from their body in just a few days.
Klose and his collaborators discovered that Vibrio cholerae, which normally lives in oceans and rivers, senses a shift in temperature as it enters the human body through a mechanism called a Ribonucleic Acid (RNA) thermometer. The thermometer detects the higher body temperature of 98.6 degrees Fahrenheit, and then turns on the virulence factors that lead to cholera.
Klose's laboratory showed that interfering with the thermometer prevents the bacteria from causing disease, suggesting possible therapeutic outcomes from this research. The research collaboration stemmed from a long friendship between Klose and Franz Narberhaus, who trained as microbiologists together at U.C. Berkeley 25 years ago.
"The temperature shift is one of the signals that the bacterium uses to turn on the virulence factors, such as the cholera toxin, that cause the disease," said Klose. "We have shown that the bacteria's thermometer controls temperature-dependent expression of the virulence factors. They only express them when they are at body temperature and not at ocean temperature."
"We found that if the RNA thermometer is prevented from working correctly and detecting the right temperature, the bacteria won't cause any disease at all. The organisms will just pass right through the body," explained Klose. "If you can figure out how to disrupt the RNA thermometer in some manner, then you may have a therapy against this disease."
Klose says the long-term goal is to come up with intervention strategies against cholera. Understanding exactly how the bacterium controls the expression of the virulence factors is one step forward in trying to intervene during cholera epidemics.
The College of Engineering invites you to the Tech Symposium showcasing innovative student projects & research performed across multiple disciplines. The symposium will not only include work in engineering, but also advances achieved in business and science.
Convocation Center, Main Campus
The Historical Trumpets and Flutes are premier chamber ensembles within the US Army Old Guard Fife and Drum Corps. actively serving their community and official military ceremonies will perform at UTSA. The concert is free and open to the public.
Arts Building, Band Rehearsal Hall (ARTS 2.03.20), Main Campus
Free presentation: Join us as we take a virtual tour of La Provence led by Claudia Carvalho. You will have an opportunity to immerse yourself in France and French culture by experiencing it from a touristical and cultural perspective.
McKinney Humanities (MH 2.01.04), Main Campus
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Durango Building, Southwest Room (DB 1.124), Downtown Campus
The unofficial Fiesta event is an alcohol-free party that's a favorite among the UTSA community and San Antonio families. There will be free food, live music and other activities. Students will also be able to test out texting and driving and drunk driving simulators.
Paseo, Main Campus
United to Serve is a System-wide volunteer initiative involving UT System students, administrators, faculty and staff. Join fellow Roadrunner volunteers for this kickoff event prior to volunteering.
University Center Lawn, Main Campus
This session will cover Texas' high school graduation requirements and more. It is geared toward parents and families of middle school students planning for high school entry and students already in high school considering going to college.
Buena Vista Street Building, Aula Canaria Auditorium (BVB 1.328), Downtown Campus
UTSA Music Biz Day is an annual music symposium for the San Antonio community and students to network with music professionals and learn about how to get involved in the industry independent of experience. The event is free and open to all.
Arts Building, Recital Hall (ARTS 2.03.02), Main Campus
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