(Jan. 25, 2016) -- Carlos Paladini, UTSA associate professor of neuroscience, has received a $1.8 million grant from the National Institutes of Health to take a closer look at dopamine bursts in the brain. Paladini, who has done extensive research on methods to treat drug addiction by manipulating dopamine levels, hopes that this new undertaking could help people afflicted by clinical depression, drug addiction, schizophrenia or Parkinson’s disease.
Part of Paladini’s central focus will be dopamine bursts, pops of electricity in the brain that occur as neurons communicate that something exciting is about to happen. For example, a hungry person visits their favorite restaurant and sees their plate coming to the table, which causes some excitement and joy. This reward is caused by the dopamine burst in that person’s brain.
“Drug abuse hijacks that entire system,” Paladini said. “When your brain is addicted to drugs, things that bring you joy, like relationships or food, no longer bring that dopamine reward. You are only able to obtain it from drugs.”
The second part of Paladini’s focus is astrocytes, which act as messenger cells, collecting all the sensory data to let the dopamine cells know that something exciting is about to happen. He likens them to bouncers at a club.
“If the right kind of information reaches an astrocyte, then the dopamine will start firing a burst,” he said.
Because astrocytes, unlike neurons, don’t use electrical signals to communicate with each other, they’re hard to study and aren’t very well understood among neuroscientists. Paladini hopes that by gaining a better understanding of them, he can advance drug therapy to help people with diseases that are affected by dopamine levels.
UTSA’s brain research is supported by the UTSA Neurosciences Institute, of which Paladini is a member. The institute, which is part of the Department of Biology, is made up of more than two dozen top-tier scientists, studies the biological basis of human experience and behavior, as well as the origin and treatment of nervous system diseases.
“If people have overactive dopamine systems, they might hear voices, which is a symptom of schizophrenia,” he said. “On the opposite end of that spectrum is depression, whereas not having any dopamine is a sign of Parkinson’s.”
Too many astrocytes is a sign of Post Traumatic Stress Disorder (PTSD), which can occur as the result of a traumatic brain injury and is a common disorder among soldiers returning from war.
“Any kind of changes or disturbances in these astrocytes can affect these diseases known to be related to dopamine,” Paladini said. “The dopamine system is rewarding. When doesn’t work, those rewards don’t occur for things that should make us happy, and we become depressed.”
Some drugs to treat dopamine-related ailments are already being used, and more are now in clinical trials, though astrocytes are still generally mysterious to neuroscientists.
“We can’t improve upon these drugs unless we understand the cells they’re affecting,” he said. “That’s the best possible road to take.”
Learn more about the UTSA Neurosciences Institute.
Learn more about the UTSA Department of Biology.
President Taylor Eighmy is inviting all UTSA faculty and staff to "Tacos With Taylor." Take the opportunity to introduce yourself to the President at any one of these casual meet and greets.
Frio Street Building, Food Court Commons Area, Downtown Campus
Celebrate 40 years of BestFest, an annual event hosted by Roadrunner Productions as a part of UTSA Homecoming festivities. The event will feature a carnival, food and drink booths, a golf cart parade, firework and live music from Anthem.
Brackenridge Lot 1, Main Campus
Celebrate homecoming as the Roadrunners take on Rice. Come early for the Spirit Walk, tailgating, games, music and food. Stick around for a halftime show with SOSA and the crowning of Mr. and Ms. UTSA.
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The Leadership Storytelling Homecoming Brunch brings together UTSA alumni and students to share a delicious meal as well as a roundtable conversation about how experiences in college carry us forward on unique leadership journeys.
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The conference is dedicated to sharing recent knowledge and experiences gained in the area of Big Data by researchers in academia, industry and the government sectors within the areas of business, national security, infrastructure, healthcare and visualization. The conference fee is $45 and includes breakfast, lunch & parking. Free for students and non-academic government employees. Register here: https://www.regonline.com/UTSAdataconference2017.
H-E-B University Center Ballroom (HUC 1.104), Main Campus
Former National Security Advisor Susan Rice, via webcast, will examine America’s economic, political and security relations with China during CHINA Town Hall, an 80-city live discussion and Q&A on China and Sino-American relations.
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The African American Studies program proudly presents William "Cruz" Shaw, San Antonio City Councilman and UTSA Alumnus. Event is free and open to the public.
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The graduate fair is an opportunity for the UTSA student body and local San Antonio community to learn about graduate education opportunities. The event is free and open to the public.
H-E-B University Center Ballroom (1.104), Main Campus
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