(Aug. 7, 2018) -- Researchers at The University of Texas at San Antonio (UTSA) and Southwest Research Institute (SwRI) are developing a 3D printed implant that, when injected in a patient’s body, could deliver a personalized dose of medicine to treat infections and ailments such as arthritis, cancer and AIDS. The project, led by Lyle Hood in the UTSA College of Engineering and Albert Zwiener in SwRI’s Chemistry and Chemical Engineering Division, is supported by a $125,000 grant from the organizations’ Connecting through Research Partnerships (Connect) program.
For a drug to be effective, patients must take a minimum amount, but not so much that it makes them ill or causes serious harm. Subsequently, someone who needs frequent and precise doses of a specific medicine either has to take a pill each day or visit a doctor for treatment. To remedy this, the San Antonio researchers are developing an implantable device that can deliver a controlled, personalized dose of medicine over several weeks.
“The implant addresses a specific patient’s illness in addition to their medical history and other health issues,” Zwiener said. “We inject this non-invasive device into the body to deliver medicine over a significant period of time.”
The design, which Zwiener and Hood created with UTSA graduate research assistant Priya Jain, incorporates complex geometries to personalize each device to an individual’s ailment and takes advantage of the selective timing and release of the compound. The team will create the device with a specialized 3D printer at UTSA that can print biodegradable materials. This makes removal of the implant unnecessary; it will simply dissolve inside the body when the treatment is complete.
The implant is also engineered to trigger localized immunotherapy for cancer treatments. Immunotherapy enlists the body to attack cancerous tumors. The UTSA-SwRI team believes that the device’s localized treatment capabilities can trigger the body to destroy the invasive cancer.
“If clinically translated, this would allow for doctors and pharmacists to print specific dosages to meet patient’s needs,” Hood said. “In immunotherapy, most strategies employ systemic circulation through an IV line, much like chemotherapy. This can cause issues with immune reactions far away from the intended target. We hope that by delivering locally, we can keep acute effects constrained to the diseased region.”
While the implant is ideal for cancer treatment, it’s designed to be drug agnostic, meaning that it can work with any type of drug and could have a significant impact on a wide array of diseases and ailments.
The Connecting through Research Partnerships (Connect) Program, sponsored by the UTSA Office of the Vice President for Research, Economic Development and Knowledge Enterprise (VPREDKE) and the SwRI Executive Office, is a grant opportunity offered to enhance greater scientific collaboration between the two institutions and to increase both UTSA’s and SwRI’s research-funding base with cross-campus collaborative programs.
Learn more about the UTSA Department of Mechanical Engineering.
Learn more about the UTSA-SwRI Connect program.
The events are a collaborative effort between student organizations, student led-groups, and campus departments.Various locations, Main and Downtown Campuses
UTSA is a designated early voting site for the May 4 Joint, General and Special Election. Any registered Bexar County voter can skip the lines and cast a ballot at UTSA from Monday, April 22 to Tuesday, April 30.H-E-B Student Union (HSU 1.002), Main Campus
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Discussion will explore the new Master of Arts in Global Affairs offered through the Department of Political Science and Geography at UTSA. Guest speakers will include representatives from local and federal government, military, and civil society.H-E-B Student Union Travis Room (HSU 2.202), Main Campus
An evening of fine food and drink inspired by UTSA’s renowned Mexican Cookbook Collection. Proceeds from the event will support UTSA’s Mexican Cookbook Collection.Hotel Emma, 136 E Grayson St., San Antonio
Grab a friend and sign up to bowl with fellow Roadrunners and raise money for scholarships.University Bowl, 12332 I-10 #10, San Antonio
The UTSA Department of Art and Art History present the work of emerging artists who are graduating from UTSA. Work ranges from traditional methods and materials, interdisciplinary and new media. Themes range from social and cultural critique to investigations that are challenging and exquisite explorations in creative form and image.Arts Building, Main Art Gallery (ART 2.03.04), Main Campus
UTSA's first spring Commencement ceremony begins at 10 a.m., May 18 and honors graduates from the College of Liberal and Fine Arts and University College.Alamodome, 100 Montana St., San Antonio
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