Specification of foundational spermatogonial stem cells

Differential regulation of the transcriptome of germ cells throughout development

Development of the baboon for studies of stem cell therapies

Early work

Meiotic sex chromosome inactivation (MSCI)

Maintenance of genetic & epigenetic intergirty in stem & germ cells

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Research in the McCarrey lab is centered on mammalian germ cells and stem cells. Experimental models include the mouse, baboon, and human samples. We are interested in the epigenetic regulation of cell functions, including determination of cell fate, maintenance of genetic integrity, regulation of gene expression, and epigenomic reprogramming in the embryo and germ lines, including genomic imprinting. We are also interested in disruption of normal epigenetic programming (epimutations) caused by either methods of assisted reproduction, environmental exposures, or adverse lifestyles, and the potential for these induced epimutations to be transmitted to subsequent generations by transgenerational epigenetic inheritance. Finally we are interested in the evolution of tissue-specific gene expression in mammalian species, and developing the baboon as a model system for testing stem cell-based therapeutic applications.

Inquiries regarding opportunities for graduate student or postdoctoral positions can be addressed to john.mccarrey@utsa.edu.


For more information about UTSA graduate programs with which Dr. McCarrey is affiliated please visit:

Cell and Molecular Biology PhD program

Biology Masters program

Biotechnology Masters program

For more information about UTSA research centers & organizations with which Dr. McCarrey is affiliated, please visit:

San Antonio Cellular Therapeutics Institute (SACTI)

RegenMed SA

Department of Cell Systems & Anatomy, UT Health San Antonio

Department of Obstetrics & Gynecology, UT Health San Antonio

Southwest National Primate Research Center

Center for reproductive Biology, Washington State University

 

John McCarrey Ph.D.