UTSA Alamo CIMA Mentor

Dr. Mark Appleford

Mechanobiology of Surface Modified Titanium Implants for Orthopedic Applications

The osseointegration of implants is directly related to their surface chemistry and topography. In the following project we explore the mechanical biology of how bone cells adhere to commonly used titanium materials. This project will introduce the student to techniques including in vitro human cell behavior, live cell imaging, quantification of cell adhesion biomarkers, and material characterization tools. The outcome of this research are to enhance the clinical success rates of implants used in orthopedics and explore fundamental cell adhesion processes.


  • Bioscience I
  • Calculus I
  • Chemistry I


  • Biochemistry
  • Cell Biology