College of Sciences

Department of Neuroscience, Developmental and Regenerative Biology

cell and UTSA logo

The Hermann Lab

Our laboratory is part of the group of stem cell and developmental biologists at the University of Texas at San Antonio. We study the stem cell system underlying spermatogenesis which are essential for male fertility. A primary interest of the lab is understanding the fundamental biology of these spermatogonial stem cells, normal male germline development, and how stem cells might be used to regenerate spermatogenesis and promote animal transgenesis in nonhuman primates. We are also actively pursuing approaches to preserve fertility in prepubertal male cancer patients.

Publications


acyl-CoA synthetase 6

Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging
Epub: N/A  |  Published: June 8, 2021
Fernandez RF, Pereyra AS, Diaz V, Wilson ES, Litwa KA, Martínez-Gardeazabal J, Jackson SN, Brenna JT, Hermann BP, Eells JB, Ellis JM. JCI Insight 6(11):e144351.

spermatogonia

Differential RA responsiveness among subsets of mouse late progenitor spermatogonia
Epub: May 5, 2021  |  Published: N/A
Suzuki S, McCarrey JR, Hermann BP. Reproduction 161(6):645-655.

mTORC1-dependent switch

An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia
Epub: February 16, 2021  |  Published: February 16, 2021
Suzuki S, McCarrey JR, Hermann BP. Cell Reports 34(7):108752.

pluripotent stem cells

Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells
Epub: N/A  |  Published: November 9, 2020
Hwang YS, Suzuki S, Seita Y, Ito J, Sakata Y, Aso H, Sato K, Hermann BP, Sasaki K. Nature Communications 11(1):5656.

epigenetic programming

Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis
Epub: September 23, 2020  |  Published: October 23, 2020
Cheng K, Chen IC, Cheng CE, Mutoji K, Hale BJ, Hermann BP, Geyer CB, Oatley JM, McCarrey JR. iScience 23(10):101596.

acyl-CoA synthetase 6

Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse
Epub: January 4, 2021  |  Published: September 27, 2019
Hale BJ, Fernandez RF, Kim SQ, Diaz VD, Jackson SN, Liu L, Brenna JT, Hermann BP, Geyer CB, Ellis JM. Journal of Biological Chemistry 294(39):14394-14405.

tissue cryopreservation

Testicular tissue cryopreservation: 8 years of experience from a coordinated network of academic centers
Epub: N/A  |  Published: May 21, 2019
Valli-Pulaski H, Peters KA, Gassei K, Steimer SR, Sukhwani M, Hermann BP, Dwomor L, David S, Fayomi AP, Munyoki SK, Chu T, Chaudhry R, Cannon GM, Fox PJ, Jaffe TM, Sanfilippo JS, Menke MN, Lunenfeld E, Abofoul-Azab M, Sender LS, Messina J, Klimpel LM, Gosiengfiao Y, Rowell EE, Hsieh MH, Granberg CF, Reddy PP, Sandlow JI, Huleihel M, Orwig KE. Human Reproduction 34(6):966-977.

RA responsiveness

Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse
Epub: N/A  |  Published: May 13, 2019
Velte EK, Niedenberger BA, Serra ND, Singh A, Roa-DeLaCruz L, Hermann BP, Geyer CB. Development 146(12):dev173088.

SSC transcriptome

The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids
Epub: November 6, 2018  |  Published: November 6, 2018
Hermann BP, Cheng K, Singh A, Roa-De La Cruz L, Mutoji KN, Chen IC, Gildersleeve H, Lehle JD, Mayo M, Westernströer B, Law NC, Oatley MJ, Velte EK, Niedenberger BA, Fritze D, Silber S, Geyer CB, Oatley JM, McCarrey JR. Cell Reports 25(6):1650-1667.e8.

cytoplasmic projections

Dynamic cytoplasmic projections connect mammalian spermatogonia in vivo
Epub: N/A  |  Published: August 13, 2018
Niedenberger BA, Cook K, Baena V, Serra ND, Velte EK, Agno JE, Litwa KA, Terasaki M, Hermann BP, Matzuk MM, Geyer CB. Development 145(15):dev161323.

cell

G-CSF promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy
Epub: January 11, 2017  |  Published: N/A
Kotzur T, Benavides-Garcia R, Mecklenburg J, Sanchez J, Reilly R and Hermann BP. 2017. Reproductive Biology and Endocrinology 15:7.

TSPAN8

TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis
Epub: October 12, 2016  |  Published: December 1, 2016
Mutoji K, Singh A, Nguyen T, Gildersleeve H, Kaucher AV, Oatley MJ, Oatley JM, Velte EK, Geyer CB, Cheng K, McCarrey JR and Hermann BP. 2016. Biology of Reproduction 95(6):117, 1–14.

graph

The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia
Epub: April 11, 2016  |  Published: June 1, 2016
Lovelace DL, Gao Z, Mutoji KN, Ruan J, and Hermann BP. 2016. Development 143: 1893-1906.

SCC differentiation

Mechanisms regulating spermatogonial differentiation
Epub: N/A  |  Published: 2016
Mecklenburg JM and Hermann BP. 2016. Results Probl Cell Differ 58:253-87.

chart

Adult Human Mesenchymal Stem Cell Differentiation at the Cell Population and Single-Cell Levels Under Alternating Electric Current
Epub: December 28, 2015  |  Published: January 27, 2016
Wechsler ME, Hermann BP, and Bizios R. 2016. Tissue Engineering Part C: Methods 22(2): 155-164.

BOR-singlecell-PCA

Transcriptional and Translational Heterogeneity among Neonatal Mouse Spermatogonia
Epub: January 7, 2015  |  Published: February 2015
Hermann BP, Mutoji KN, Velte EK, Ko D, Oatley JM, Geyer CB, and McCarrey JR. 2015. Biology of Reproduction 92(2):54, 1-12.

granulocyte

Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy
Epub: November 5, 2014  |  Published: January 2015
Benavides-Garcia R*, Joachim R*, Pina N, Mutoji KN, Reilly M, and Hermann BP. Fertility and Sterility 03(1):270-280.e8. (*equal contribution.)

GnRH

Hormone suppression with GnRH antagonist promotes spermatogenic recovery from transplanted spermatogonial stem cells in irradiated cynomolgus monkeys
Epub: September 30, 2013  |  Published: November 2013
Shetty G, Uthamanthil RK, Zhou W, Shao SH, Weng CC, Tailor RC, Hermann BP, Orwig KE and Meistrich ML. Andrology. 1(6):886-98.

graph

Eliminating malignant contamination from therapeutic human spermatogonial stem cells
Epub: March 15, 2013  |  Published: April 1, 2013
Dovey SL, Valli H, Hermann, B.P., Sukhwani M, Donohue J, Castro CA, Chu T, Sanfilippo JS, Orwig KE. Journal of Clinical Investigation. 123(4):1833-43.

transplantation

Spermatogonial stem cell transplantation into Rhesus testes regenerates spermatogenesis producing functional sperm
Epub: November 2, 2012  |  Published: November 2012
Hermann, B.P., Sukhwani, M., Winkler, F. Pascarella, J.N., Peters, K.A., Sheng, Y., Valli, H., Rodriguez, M., Ezzelarab, M., Dargo, G., Peterson, K., Masterson, K., Ramsey, C., Ward, T., Lienesch, M., Volk, A., Cooper, D.K.C., Thomson, A.W., Kiss, J.E., Penedo, M.C.T., Schatten, G.P., Mitalipov, S., and Orwig, K.E. Cell Stem Cell. 11(5): 715-726.

direct differentiation

Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells
Epub: August 23, 2012  |  Published: September 2012
Easley IV, C.A., Phillips, B.T., McGuire, M.M., Barringer, J.M., Valli, H., Hermann, B.P., Simerly, C.R., Rajkovic, A., Miki, T., Orwig, K.E., and Schatten G.P. Cell Reports. 2(3):440-6.

dot plot

Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions
Epub: October 20, 2011  |  Published: December 2011
Hermann, B.P., Sukhwani, M., Salati, J., Chu, T., Sheng, Y., and Orwig, K.E. Human Reproduction. 26(12):3222-31.

marker

The elusive spermatogonial stem cell marker?
Epub: May 12, 2011  |  Published: August 2011
Hermann, B.P., Phillips, B.T., and Orwig, K.E. Biology of Reproduction. 85: 221-3.

book cover

Male Germline Stem Cells: Developmental and Regenerative Potential. (Book)
Epub: N/A  |  Published: January 2011
Orwig, K.E. and Hermann, B.P. (editors) Springer. New York, NY.

stem cell transplantation

Translating spermatogonial stem cell transplantation to the clinic. (Book chapter)
Epub: N/A  |  Published: January 2011
Hermann, B.P. and Orwig, K.E. in Male Germline Stem Cells: Developmental and Regenerative Potential. Orwig, K.E. and Hermann, B.P. (editors) Springer. New York, NY.

GFRa1

Spermatogonial stem cells in higher primates: are there differences to those in rodents?
Epub: October 30, 2009  |  Published: March 2010
Hermann, B.P., Sukhwani, M., Hansel M.C., and Orwig, K.E. Reproduction. 139:479-493.

Xeno

Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques
Epub: March 31, 2009  |  Published: July 2009
Hermann, B.P., Sukhwani, M., Simorangkir, D., Chu, T., Plant, T., and Orwig, K.E. Human Reproduction. 24(7):1704-16.

usf model

In vivo regulation of FSH-receptor (Fshr) by the transcription factors USF1 and USF2 is cell specific
Epub: June 19, 2008  |  Published: October 2008
Hermann, B.P., Hornbaker, K., Rice, D.A., Sawadogo, M., and Heckert, L.L. Endocrinology. 149(10):5297-306.

nHP-tubule

Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques
Epub: June 21, 2007  |  Published: September 2007
Hermann, B.P., Sukhwani, M., Lin, C., Sheng, Y., Tomko, J., Rodriguez, M., Shuttleworth, J., McFarland, D., Hobbs, R.M., Pandolfi, P.P., Schatten, G.P., and Orwig, K.E. Stem cells. 25(9):2330-2338.

Fshr expression

Distal regulatory elements are required for Fshr expression, in vivo
Epub: November 9, 2006  |  Published: January 2007
Hermann, B.P., Hornbaker, K., Manimaran, R.R., and Heckert, L.L. Molecular and Cellular Endocrinology. 260-262: 49-58.

FSH receptor

Transcriptional regulation of the FSH receptor: new perspectives
Epub: November 2, 2006  |  Published: January 2007
Hermann, B.P. and Heckert, L.L. Molecular and Cellular Endocrinology. 260-262:100-108.

Fshr model

Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron
April 7, 2005  |  Published: August 2005
Hermann, B.P. and Heckert, L.L. Molecular Endocrinology. 19(8):2112-2131.

Lythraceae pollen

Quantitative evaluation of pollen polymorphism in a tristylous weed, Lythrum salicaria (Lythraceae)
Epub: N/A  |  Published: August 2000
Mal, T.K. and Hermann, B.P. Canadian Journal of Botany. 78(8): 1086-1094.

AJB cover

Quantitative evaluation of stigma polymorphism in a tristylous weed, Lythrum salicaria (Lythraceae)
Epub: N/A  |  Published: August 1999
Hermann, B.P. Mal, T.K., Williams, R.J. and Dollahon, N.R. American Journal of Botany. 86 (8): 1121-1129.

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