Bernard Arulanandam, Ph.D., M.B.A.
Professor and Vice President for Research, Economic Development, and Knowledge Enterprise
Jane & Roland Blumberg Professorship in Biology
Areas of Specialization
- Cellular Immunology
- Microbial Pathogenesis
- Mucosal Immunity
M.B.A. in Business Administration; University of Texas at San Antonio
Ph.D. in Microbiology & Immunology; Medical College of Ohio
M.A. in Microbiology; Minnesota State University
B.S. in Toxicology; Minnesota State University
Dr. Arulanandam's lab studies the basic mechanisms of immune defenses at mucosal sites. Mucosal surfaces form the major interface between the host and the environment, and constitute the first line of defense against bacterial pathogens. (A) Using "omics" based approaches, the lab is investigating host immunity and pathogenesis associated with pulmonary and genital Chlamydia trachomatis in murine and guinea pig models of infection. (B) Acinetobacter baumannii has emerged as an important nosocomial pathogen. The lab is focused on characterization of A. baumannii virulence factors using gastrointestinal (GI) and pulmonary infection models to delineate the role of these virulence factors in bacterial GI colonization and pathogenesis.
The Arulanandam Lab utilizes animal models including mice, rats, and guinea pigs to study pathogenesis and host immune responses following Gram-negative bacterial infection. The lab employs various immunological techniques/tools, such as confocal microscopy, flow cytometry, and ELISpot to study immune cell activation and migration in response to bacterial infection. Primary cells are also generated to establish cell coculture systems to delineate underlying immune protective mechanisms. Additionally, the lab tracks bacterial dissemination using a small animal whole body imaging system and evaluates infection induced respiratory dysfunction with the FlexiVent, a small animal ventilator. Molecular and biochemical tools are applied to generate cellular and subunit vaccine candidates against bacterial pathogens. The lab provides training opportunities to students who are interested in studying mucosal immunity against bacterial infection.