Anthony Burgos-Robles, Ph.D.
Areas of Specialization
- cortical and amygdala circuits
- learning and memory
Postdoc in Neuroscience; Massachusetts Institute of Technology
Ph.D. in Biomedical Sciences; Ponce School of Medicine, Puerto Rico
B.S. in Chemistry; Pontifical Catholic University of Puerto Rico
One of the main interests of the Burgos Lab is to understand how brain function is affected by chronic exposure to psychological stress, and how stress increases the risk for the development of mental disorders. Particularly, the Burgos Lab uses animal models and sophisticated neurophysiology approaches in behaving animals to evaluate the evolution of changes in the activity of discrete neural populations and pathways in response to stress. Furthermore, the Burgos lab evaluates how such changes in neural activity alter cognitive functions, emotion, and motivation.
Cortico-amygdala circuits which are at the center of aversive and reward processing exhibit prominent abnormalities in response to stress. Combining extracellular recordings, optogenetic, chemogenetic, and pharmacological approaches, the Burgos lab defines prominent neural features and function of discrete cortico-amygdala pathways, and determines how they get affected by stress exposure. Enduring neurophysiological alterations have already been detected, and the Burgos lab now evaluates their implication to promote dysregulation for emotional and motivational functions.
Another interest of the Burgos lab is to explore the neural substrates of social learning, which requires learning by observing others as opposed to via direct experience. In addition, the Burgos lab aims to understand how stress exposure affects social learning and the neural processes required for this important function of the brain.
Training and mentoring future generations of influential neuroscientists and leaders in the field is top priority in the Burgos lab. The lab provides a highly collaborative, supportive, and energetic atmosphere in which everyone is expected to learn from each other, share rigorous scientific standards, and work diligently to achieve their career goals and dreams.
Trainees in the Burgos lab have the opportunity to learn advanced neurophysiological techniques in freely-behaving rodents, as well as optogenetic and chemogenetic approaches to artificially turn discrete neuronal populations "ON" and "OFF" to evaluate their function and establish causal relationships with animal behavior. Other techniques in the Burgos lab include neuropharmacology, immunohistochemistry, and tissue imaging. Trainees in the Burgos lab also have the opportunity to pursue scientific questions related to their interests, design their experiments, and develop innovative behavioral assays to evaluate complex neural functions.
Applicants with computational skills, particularly with expertise on matlab coding and machine learning, are encouraged to apply.
Click here for a list of publications.