UTSA COS Summer Research Experience
Mentors and Research
Q Fever is caused by Coxiella burnetii, an obligate, intracellular pathogen. Acute Q fever is a self-limiting flu-like illness and is readily amenable to treatment with antibiotics. Chronic Q fever, on the other hand, is not easily treated with antibiotics and results in endocarditis, hepatitis, and pneumonia. The lab's current research efforts are therefore directed towards (1) identification of T cell epitopes of C. burnetii, (2) modification of select C. burnetii antigens to enhance protective T cell response against C. burnetii, and (3) generation of targeted deletion mutants of Phase II C. burnetii for study intracellular trafficking kinetics in eukaryotic cells/cell lines.