(Sept. 11, 2012) -- Taking homegrown discoveries -- research findings observed in laboratories in San Antonio -- and turning them into drugs to treat disease is the focus of the Center for Innovation in Drug Discovery (CIDD) being built at both The University of Texas at San Antonio (UTSA) and the UT Health Science Center San Antonio.
Doug E. Frantz and Stanton McHardy in the UTSA Department of Chemistry are building a medicinal chemistry core facility in labs on the UTSA Main Campus. Frantz, the CIDD co-director, and McHardy, the CIDD medicinal chemistry core director, have nearly 20 years of experience between them with Merck and Pfizer.
"Several top-tier universities have established centers dedicated to the discovery and development of new drugs that will treat devastating human diseases," said Frantz, whose vision was a driving force in the center's formation. "The most successful of these enterprises have included faculty and research staff who bring pharmaceutical industry experience to the table. Both Dr. McHardy and I have worked on U.S. Food and Drug Administration-approved drugs during our professional careers, and we believe these experiences will greatly benefit the CIDD here in San Antonio."
CIDD Co-Director Bruce Nicholson, professor and chair of biochemistry in the School of Medicine at the UT Health Science Center, and Matthew Hart, the CIDD high-throughput screening director, are developing a high-content/high-throughput screening core facility that will enable researchers to rapidly sift through thousands of potentially therapeutic compounds. This will be housed at the Joe R. and Teresa Lozano Long Campus of the Health Science Center starting in November, but the high-content imaging screens are already operational in temporary laboratories at the Texas Research Park.
"In order to identify small molecules or peptides that can bind to a protein or impact a cellular process that could represent a good target for disease therapy, you need the capacity to test and compare thousands of compounds to see which one works the best," said Nicholson. "The high-throughput and high-content screening facility will bring this capability to the San Antonio research community. We will offer not only biochemical screens to test how well potential drugs bind their targets, but we will also provide screens of live cells to assess compound effects on cell behavior."
The CIDD is designed to help develop drugs out of original discoveries made at the Health Science Center and UTSA to treat all forms of disease and infection. "San Antonio has always been among the top Phase I centers in the country," said Nicholson. "But, what we've not done very much is take homegrown discoveries and turn them into the next-generation drugs. This center is designed to facilitate that."
This is particularly true in the case of cancer research, where for many years most of the new drugs tested at the Cancer Therapy and Research Center did not originate from the Health Science Center.
Phase I cancer studies are conducted to demonstrate a novel agent's safety in patients whose tumors are not responding to existing therapies. Phase II and further studies define optimum use of the medications.
The earliest phases of pre-clinical drug discovery can take many forms. Structural biology studies at the Health Science Center have identified many protein targets for therapy in Alzheimer's disease, Parkinson's disease, diabetes, cancer and other disorders, and teams are in the process of obtaining high-resolution structures of these targets. This can be very effective in guiding the design of new drugs.
In other cases, scientists in many departments at the Health Science Center and UTSA have identified specific cellular processes central to the development of a disease that present ideal targets for therapy and in some cases have identified compounds or novel plant extracts that can affect them.
"The pre-clinical advancement of new small molecule drug-like candidates requires a multi-disciplinary approach and a diverse platform of research support," said McHardy. "The overall strategy for the CIDD at UTSA and the Health Science Center is to pull the successful strategies used in the pharmaceutical and biotechnology sectors and provide them to researchers to help advance small-molecule therapeutics for truly novel pharmacological targets and the treatment of numerous diseases."
Education is another key component of the center. Currently, UTSA undergraduate and graduate students in Frantz's laboratory are conducting research on breast cancer, prostate cancer and regenerative medicine involving stem cell differentiation, and addressing diabetes and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Additionally, many graduate students at the Health Science Center are involved in designing therapeutic strategies to combat these same diseases. New courses in the emerging area of academic biomedical research are being developed and could lay the groundwork for a future graduate training program between these institutions.
The new center is expected to help with recruitment of outstanding faculty and graduate students to San Antonio in the field of medicinal chemistry and drug discovery. "Fruitful interactions are also anticipated between the CIDD and the UT Health Science Center's Institute for Integration of Medicine and Science (IIMS)," said IIMS Director Robert Clark, M.D. "Accelerating the pathway of drug discovery and development from the laboratory bench to initial testing in patients is one of our key objectives, and we are very enthusiastic about the impact that the CIDD will have in this area."
"Texas is seeing burgeoning development in biotech and drug discovery, and this new initiative will allow our students to have research opportunities that could eventually have global impacts on therapeutic treatments for patients," Frantz said. "I think this center will be a huge attraction and recruiting tool for us to show outstanding chemists why UTSA, working alongside the UT Health Science Center, is on a phenomenal trajectory to reach Tier One status."
State and private funding of $3.5 million is launching the CIDD. Support from the Texas Legislature is enabling renovation of existing research space, and the Legislature also provided funds through the San Antonio Life Sciences Institute. A generous private gift will be announced soon by UTSA.
The University of Texas at San Antonio is one of the largest of nine academic universities and six health institutions in the UT System. As a multicultural institution, UTSA aims to be a national research university providing access to educational excellence and preparing citizen leaders for the global environment. UTSA serves nearly 31,000 students in 135 degree programs in the colleges of architecture, business, education and human development, engineering, honors, liberal and fine arts, public policy, sciences and the Graduate School. Founded in 1969, UTSA is an intellectual and creative resource center and a socioeconomic development catalyst for Texas and beyond.
The University of Texas Health Science Center at San Antonio, one of the country's leading health sciences universities, ranks in the top 3 percent of all institutions worldwide receiving federal funding. Research and other sponsored program activity totaled $231 million in fiscal year 2011. The university's schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced approximately 28,000 graduates. The $736 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg.
The UTSA Department of Physics and Astronomy's Curtis Vaughan Observatory will offer free stargazing for the public beginning on top of the 4th floor of the Flawn Science Building. Experienced astronomers will be on hand to show a variety of astronomical objects and answer any questions. This event is free and open to the public, so feel free to invite friends and family.
Curtis Vaughan Observatory
This year's keynote speaker is Donalyn Miller, author of The Book Whisper. The event will feature breakout sessions and a presentation by the Creative Writers from North East School of the Arts. The event is free and open to all teachers from Pre-K through university level. Attendees can earn a certificate for 3 hours of Professional Development Credit.
Riklin Auditorium (FS1.406), Downtown Campus
The UTSA community is invited to attend the 3rd annual Rowdy Gras celebration! This year Rowdy Gras includes a daytime event from 11 a.m. -1 p.m. with a free food tasting and music on the UC Paseo. The main event takes place from 6 - 9 p.m. in the UC Lawn. The event includes free food, live jazz music, activities and giveaways.
University Center Paseo & Lawn, UTSA Main Campus
The UTSA College of Architecture, Construction and Planning’s 2015-16 Speaker Series continues with Dana Cuff, Ph.D., a professor of architecture and urbanism at the University of California, Los Angeles. In her talk, Cuff will discuss new forms of “studio” and new types of practices. Free and open to the public.
Aula Canaria Lecture Hall (BV 1.328), UTSA Downtown Campus
The UTSA Institute of Texan Cultures invites Texas and Texans to the Asian Festival. What began as a traditional family reunion for the Chinese New Year has expanded to include other Asian communities and participants, showcasing their unique culture and traditions.
The UTSA Institute of Texan Cultures
Join the UTSA Department of Interdisciplinary Learning and Teaching in celebrating interdisciplinary inquiry at the 2016 Interdisciplinary Studies Colloquium. The colloquium will include a panel of faculty and recent doctoral graduate and a showcase of the best IDS undergraduate inquiry projects of the year 2015. The event is free and open to the public.
Business Building (BB 2.06.04), UTSA Main Campus
The UTSA College of Public Policy presents the Dean's Distinguished Lecture Series featuring Dr. Iris Carlton-LaNey, Professor of the School of Social Work at the University of North Carolina-Chapel Hill. Dr. Iris Carlton LaNey will speak to the UTSA community about the role and impact of African-Americans in the social work profession.
Buena Vista Theater (BV 1.326), Downtown Campus
Please join us for a presentation and book signing by Luis Carlos Montalván (Fmr. Capt., USA), author of the New York Times Bestseller Until Tuesday and the international award-winning childrens book Tuesday Tucks Me In. His books will be available for purchase at the UTSA Bookstore. This event is free and open to the public.
Southwest Room (DB 1.124), Downtown Campus
The 12th Annual Black Heritage Gala is a formal event which includes a student performance, keynote remarks by Michael Brown, an award presentation, dinner and dancing. Tickets are $10 for UTSA students and $15 for all other guests. Tickets are on sale now at Roadrunner Express. Contact (210) 458-4770 for more information.
H-E-B University Center Ballroom, Main Campus
The UTSA Institute of Texan Cultures will host a free workshop focusing on teaching Latin American culture and geography for students seeking their teacher certification. The workshop includes free resources for teaching Latin American subject matter as well as presentations on language, identity, music, geography, and political and developmental history, and a special educators’ tour of the museum’s Los Tejanos exhibit. Free with registration.
The UTSA Institute of Texan Cultures (ITC 3.01.02)
Faithful Alabi holds the Raw Teen III American deadlift record
2015 was a significant year for UTSA. As the university moved forward on the road to Tier One research, designations and recruitment of high caliber faculty and students, it also completed its first ever capital campaign. Read about UTSA's accomplishments in the 2015 Year in Review as we look forward to what the next year will bring.
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
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