UTSA study describes drug that could prevent infertility in cancer patients
(Feb. 13, 2017) -- A new study led by Brian Hermann, assistant professor of biology at The University of Texas at San Antonio (UTSA), shows promising evidence that a medication previously used to prevent infections in cancer patients can also keep them from becoming infertile. Losing fertility is a frequent problem among cancer patients, as treatments for the disease often halt sperm production.
Hermann and his research team have been pursuing a number of cutting-edge research initiatives to restore fertility in men who have lost their ability to have children as a result of cancer treatments they received as children. While working on methods to restart sperm production, the researchers discovered a link between a drug for recovering cancer patients and the absence of normal damage to reproductive ability.
The drug is called G-CSF or granulocyte colony-stimulating factor. It stimulates the bone marrow to produce neutrophils, which are white blood cells that are needed to fight infections. They're commonly lost after chemotherapy and radiation treatments.
"We were using G-CSF to prevent infections in our research experiments," Hermann said. "It turned out that the drug also had the unexpected impact of guarding against male infertility."
Because cancer treatments like radiation and chemotherapy often kill sperm stem cells, male reproduction becomes essentially impossible. In Hermann's laboratory, G-CSF, by promoting cell growth, unexpectedly began creating new sperm stem cells to replace the dead ones.
A study authored by Hermann and his students was recently published in Reproductive Biology and Endocrinology. Hermann's laboratory focuses almost exclusively on regenerating dead testicular tissue through the use of stem cells, making the project an exciting but unexpected detour that he hopes to continue, if possible.
The next step would be observing whether the drug, which is already in wide use by cancer patients, has any correlation with restored fertility among humans. Until then, Hermann is focusing on better understanding the stem cells that make reproduction possible, so he can find more effective solutions to treating male infertility.
"Male infertility is an intuitive disease and we need creative solutions," he said. "But we need to understand how things work before we can fix them."
UTSA is ranked among the top 400 universities in the world and among the top 100 in the nation, according to Times Higher Education.
Read Brian Hermann's study, "Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy."
Learn more about the UTSA Department of Biology.
Connect with UTSA online at Facebook, Twitter, YouTube, Instagram and LinkedIn.
Dr. Michael Doyle has had an immense impact on the field of catalysis and organic chemistry. Join in a one-day symposium. In order to honor Dr. Doyle’s colossal career accomplishments with his upcoming retirement, we are holding a one day symposium eventRiklin Auditorium (FS 1.406,) Frio Street Building, Downtown Campus
The San Antonio Military Health and Universities Research Forum (SURF) attracts presenters from around the nation to showcase the work of students, trainees, faculty and staff. The mission of the SURF conference is to “advance research collaborations among academic, military, and industry partners to improve health outcomes and readiness.”TBD
The NHERI Summer Institute is a free event for early-career faculty, NHERI Graduate Student Council, K-12 educators from the San Antonio area, engineers, and researchers to learn more about the Natural Hazards Engineering Research Infrastructure (NHERI) community.La Villita Room (DBB 1.116,) Durango Building, Main Campus
Connect with peer mentors and fellow first-gen and transfer students, and learn how you can join UTSA's First-Gen programs for the Fall 2023 semester.Mentoring Hub (MS 2.02.02,) Multidisciplinary Studies Building, Main Campus
Building the Dual Language Leader Symposium will provide a safe space for current and aspiring leaders to learn best practices, theories, policies, and systems that support a dual language bilingual education.UTSA Southwest Campus, 300 Augusta St.
Streaming of Spray the Word that will conclude with a discussion with San Antonio's Poet Laureate, Andrea "Vocab" Sanderson.Aula Canaria (BVB 1.328,) Buena Vista Street Building, Downtown Campus
Celebrate Hispanic Heritage Month at our very own street fair - Calle UTSA. We will have activities, performances, food, music, and pinatas to break open! All free to UTSA students, faculty, and staff.Student Union Paseo, Main Campus