(June 11, 2018) -- A new study by Waldemar Gorski, professor and chair of the UTSA Department of Chemistry, and Stanton McHardy, associate professor of research in chemistry and director of the UTSA Center for Innovative Drug Discovery, describes a method that could show quickly and accurately whether a person has been infected with harmful bacteria or other pathogens. Additionally, this new method shows the exact severity of infection in a person.
The most common method of testing for infection in medical facilities is a strip that turns a certain color when infected fluids come into contact with it.
“The problem with this method is that it’s imprecise,” Gorski said. “The human eye is forced to judge the level of infection based on the hue and deepness of a color. It’s difficult to make an accurate call based on that.” Furthermore, roughly a third of samples cannot be tested because the fluids contain blood or are too opaque.
Other methods include microbiology or examining body fluid samples under a microscope and counting white blood cells, also known as leukocytes, which are an indicator of an infection. However, these can be slow processes and require more highly trained personnel.
Gorski, seeing a need for an easier and more rapid method of testing for infection, resolved to test an electrochemical approach, and sought out McHardy, a medicinal chemist. Together, they created molecules that bind to leukocyte enzymes and produce an electrical current to signal the presence of an infection.
Their new molecules are housed on a testing strip. After being contacted with infected bodily fluids, the strip is connected to a computer monitor that displays a clear range of electrochemical responses demonstrating the severity of an infection.
“The signs and symptoms people demonstrate aren’t always reflective of the level of the infection they have,” McHardy said. “This method could very easily show just how serious an infection is and make diagnosis a much quicker process, possibly preventing a more serious illness.”
Gorski believes the method could be especially useful to people who have just undergone surgery, as it could determine definitively whether they have an infection from the procedure before it worsens.
To date, Gorski and McHardy have filed a patent for their invention, published two papers and plan to work with an engineer in the future to streamline its design.
Read Waldemar Gorski and Stanton McHardy’s study, “Synthesis and Characterization of Pyridine Compounds for Amperometric Measurements of Leukocyte Esterase.”
Learn more about the UTSA Department of Chemistry.
Learn more about the UTSA Center for Innovative Drug Discovery.
UTSA invites you to participate in our community altar by RSVP to this event. You can also use this link to learn more about Día de Los Muertos:https://anendlessconnection.weebly.com/the-project.html.Student Union Window Lounge, Main Campus
UTSA students, faculty, and staff are invited to the Health Fair on Wednesday. Health and wellbeing information booths and health screenings will be available.HEB Student Union Paseo, Main Campus
The South Texas Blood and Tissue Center will on campus Wednesday, October 27th from 10am - 3pm in the H-E-B Student Union Ballroom 1 for an additional day this month. Participants will receive a $10 gift card by email from hundreds of retailers and restaurants through your donor portal.HEB Student Union Ballroom I, 1.104, Main Campus
The second of two recitals featuring the tuba and euphonium students of Gary Poffenbarger and John Caputo. More details to come. The Fall 2021 concert schedule is subject to change. Please continue to monitor our website and social media for updates. This concert will be live-streamed via the UTSA Music Facebook page. https://www.facebook.com/UTSAMusicUTSA Recital Hall, Main Campus
October 28th celebrates National Immigrants Day. On this day, we gather to explore the diverse heritage of our nation’s social fabric. We dedicate this day to understanding how our nation was founded and built by immigrants. Our goal is for the UTSA family to recognize and celebrate how all immigrants, regardless of their citizenship status, contribute to our community through their resiliency and ingenuity.Multicultural Student Lounge, HSU 2.207, Main Campus
The COLFA Advanced Career Pathways Workshops are focused on connecting your education with your career aspirations and exploring your pathways to reach your goal.Mesquite Room, Student Union, 2.01.24, Main Campus
The Westside Community Center will be creating an altar or "ofrenda" as many do within San Antonio and the Westside for "Dia de los Muertos." If you would like to participate, we invite you to send in a photo of a loved one that will be placed in this space. You are welcome to join us on October 28th at 3:00 pm to set up the space and come see us at the Westside Community Center.UTSA Westside Community Center, 1310 Guadalupe St., San Antonio, TX 78207
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