(April 17, 2019) -- Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. To improve that survival rate, researchers at UTSA and the University of Texas MD Anderson Cancer Center created an online atlas to identify and classify protein signatures present at AML diagnosis.
The new protein classifications will help researchers and clinicians recommend better treatment and personalized medicine for patients suffering from this aggressive cancer, which occurs in the blood and bone marrow. The breakthrough research is published in the latest April issue of Nature Biomedical Engineering.
Amina Qutub is an Associate Professor in the UTSA Department of Biomedical Engineering.
Researcher Amina Qutub, an associate professor in the UTSA Department of Biomedical Engineering (who joined UTSA in 2018 from Rice University), and oncologist Steven M. Kornblau, a professor and practicing clinician in the Department of Leukemia at UT MD Anderson Cancer Center, examined the genetic, epigenetic and environmental diversity that occurs in cancerous cells due to AML. Analyzing proteomic screens of 205 patient biopsies obtained at MD Anderson Cancer Center, first author Chenyue Wendy Hu (then a graduate student at the Qutub Lab, now at Uber Technologies), Kornblau and Qutub developed a new computational method called MetaGalaxy to categorize the protein signatures into 154 different patterns based on their cellular functions and pathways.
By approaching this challenge through the unique lens of developing a quantitative map for each leukemia patient from protein expression in their blood and bone marrow, rather than the standard lens of qualitative metrics and genetic risks alone, Qutub, Kornblau and their research collaborators will be able to more precisely categorize patients into risk groups and better predict their treatment outcomes.
To better understand the AML hallmarks at the proteomic (protein system) level and to share the results of their work with other researchers, the UTSA biomedical engineering professor and her team including Hu, and students Andrew Ligeralde (now at the University of California, Berkeley) and Allie Raybon (from the UTSA Department of Biomedical Engineering) built a web portal known as the Leukemia Proteome Atlas. Designed by Qutub’s and Kornblau’s teams with input from clinical collaborators worldwide, the online portal gives oncologists and cancer scientists the tools they need to investigate AML protein expression patterns from one patient to the next. It also provides investigators around the world with leads for new leukemia research and new computational tools.
Since many genetic mutations cannot be targeted, the proteomic profiling and target identification process used in this research study will accelerate the identification of therapeutic targets. It also propels researchers much closer to the development of personalized combination therapies for patients based on their unique protein signatures.
“Acute myelogenous leukemia presents as a cancer so heterogeneous that it is often described as not one, but a collection of diseases,” said Qutub. “To decipher the clues found in proteins from blood and bone marrow of leukemia patients, we developed a new computer analysis - MetaGalaxy – that identifies molecular hallmarks of leukemia. These hallmarks are analogous to the way constellations guide navigation of the stars: they provide a map to protein changes for leukemia. Our ‘hallmark’ predictions are being experimentally tested through drug screens and can be ‘programmed’ into cells through synthetic manipulation of proteins. A next step to bring this work to the clinic and impact patient care is testing whether these signatures lead to the aggressive growth or resistance to chemotherapy observed in leukemia patients. At the same time, to rapidly accelerate research in leukemia and advance the hunt for treatments, we provide the hallmarks in an online compendium where fellow researchers and oncologists worldwide can build from the resource, tools and findings, LeukemiaAtlas.org.”
Learn more about the Leukemia Proteome Atlas and read the paper in Nature Biomedical Engineering.
Celebrate UTSA’s 50th Anniversary and share social media posts about the 50th using the hashtag #UTSA50.
Connect with UTSA online at Facebook, Twitter, YouTube, Instagram and LinkedIn.
UTSA Today is produced by University Communications and Marketing, the official news source of The University of Texas at San Antonio. Send your feedback to news@utsa.edu. Keep up-to-date on UTSA news by visiting UTSA Today. Connect with UTSA online at Facebook, Twitter, Youtube and Instagram.
In this hands-on workshop, participants will learn to setup an EndNote library, save references and PDFs, and automatically create and edit a bibliography. Attendees are encouraged, but not required, to have EndNote already installed on a personal computer.
Virtual EventJoin this annual community celebration of Mexico’s independence sponsored by the Avenida Guadalupe Association. UTSA’s Westside Community Center—located at the parade’s starting location at Guadalupe and Brazos Streets—will be open to visitors for the duration of the event.
UTSA Westside Community Center, 1310 Guadalupe St, San Antonio, TX 78207Don’t mind the writing but hate formatting citations and bibliographies? Working on your thesis or dissertation, or even a long paper this semester? Citation managers such as Zotero® can help you store and organize the citations you find during your research. Take part in this session about using Zotero®.
Virtual EventDid you know the library offers much more than books and study spaces? Our librarians can also support your research and publishing and strengthen your instruction. Join us for a one-hour workshop about all that UTSA Libraries offers.
Virtual EventAre you interested in learning more about incorporating digital methods into your research? This workshop will introduce you to approaches and tools that can help support your research. Through hands-on activities, you will learn about text analysis and digital mapping and how these methods can enrich your projects.
Group Spot B, 2.01.22, John Peace LibraryLearn to use the simple but powerful features of EndNote®, a citation management tool. In this hands-on workshop, participants will learn to setup an EndNote library, save references and PDFs, and automatically create and edit a bibliography.
Virtual EventAproduction of the Gudalupe Cultural Arts Center, Rio Bravo showcases the vibrant music and dance traditions of the Texas-Mexico border region. Featuring the Guadalupe Dance Company and Mariachi Azteca de América, the performances will be filmed live both nights, courtesy of UTSA's College of Liberal and Fine Arts.
UTSA Downtown CampusThe University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.
UTSA is a proud Hispanic Serving Institution (HSI) as designated by the U.S. Department of Education .
The University of Texas at San Antonio, a Hispanic Serving Institution situated in a global city that has been a crossroads of peoples and cultures for centuries, values diversity and inclusion in all aspects of university life. As an institution expressly founded to advance the education of Mexican Americans and other underserved communities, our university is committed to promoting access for all. UTSA, a premier public research university, fosters academic excellence through a community of dialogue, discovery and innovation that embraces the uniqueness of each voice.
