(April 17, 2019) -- Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. To improve that survival rate, researchers at UTSA and the University of Texas MD Anderson Cancer Center created an online atlas to identify and classify protein signatures present at AML diagnosis.
The new protein classifications will help researchers and clinicians recommend better treatment and personalized medicine for patients suffering from this aggressive cancer, which occurs in the blood and bone marrow. The breakthrough research is published in the latest April issue of Nature Biomedical Engineering.
Researcher Amina Qutub, an associate professor in the UTSA Department of Biomedical Engineering (who joined UTSA in 2018 from Rice University), and oncologist Steven M. Kornblau, a professor and practicing clinician in the Department of Leukemia at UT MD Anderson Cancer Center, examined the genetic, epigenetic and environmental diversity that occurs in cancerous cells due to AML. Analyzing proteomic screens of 205 patient biopsies obtained at MD Anderson Cancer Center, first author Chenyue Wendy Hu (then a graduate student at the Qutub Lab, now at Uber Technologies), Kornblau and Qutub developed a new computational method called MetaGalaxy to categorize the protein signatures into 154 different patterns based on their cellular functions and pathways.
By approaching this challenge through the unique lens of developing a quantitative map for each leukemia patient from protein expression in their blood and bone marrow, rather than the standard lens of qualitative metrics and genetic risks alone, Qutub, Kornblau and their research collaborators will be able to more precisely categorize patients into risk groups and better predict their treatment outcomes.
To better understand the AML hallmarks at the proteomic (protein system) level and to share the results of their work with other researchers, the UTSA biomedical engineering professor and her team including Hu, and students Andrew Ligeralde (now at the University of California, Berkeley) and Allie Raybon (from the UTSA Department of Biomedical Engineering) built a web portal known as the Leukemia Proteome Atlas. Designed by Qutub’s and Kornblau’s teams with input from clinical collaborators worldwide, the online portal gives oncologists and cancer scientists the tools they need to investigate AML protein expression patterns from one patient to the next. It also provides investigators around the world with leads for new leukemia research and new computational tools.
Since many genetic mutations cannot be targeted, the proteomic profiling and target identification process used in this research study will accelerate the identification of therapeutic targets. It also propels researchers much closer to the development of personalized combination therapies for patients based on their unique protein signatures.
“Acute myelogenous leukemia presents as a cancer so heterogeneous that it is often described as not one, but a collection of diseases,” said Qutub. “To decipher the clues found in proteins from blood and bone marrow of leukemia patients, we developed a new computer analysis - MetaGalaxy – that identifies molecular hallmarks of leukemia. These hallmarks are analogous to the way constellations guide navigation of the stars: they provide a map to protein changes for leukemia. Our ‘hallmark’ predictions are being experimentally tested through drug screens and can be ‘programmed’ into cells through synthetic manipulation of proteins. A next step to bring this work to the clinic and impact patient care is testing whether these signatures lead to the aggressive growth or resistance to chemotherapy observed in leukemia patients. At the same time, to rapidly accelerate research in leukemia and advance the hunt for treatments, we provide the hallmarks in an online compendium where fellow researchers and oncologists worldwide can build from the resource, tools and findings, LeukemiaAtlas.org.”
Celebrate UTSA’s 50th Anniversary and share social media posts about the 50th using the hashtag #UTSA50.
UTSA invites you to participate in our community altar by RSVP to this event. You can also use this link to learn more about Día de Los Muertos:https://anendlessconnection.weebly.com/the-project.html.Student Union Window Lounge, Main Campus
October 28th celebrates National Immigrants Day. On this day, we gather to explore the diverse heritage of our nation’s social fabric. We dedicate this day to understanding how our nation was founded and built by immigrants. Our goal is for the UTSA family to recognize and celebrate how all immigrants, regardless of their citizenship status, contribute to our community through their resiliency and ingenuity.Multicultural Student Lounge, HSU 2.207, Main Campus
The COLFA Advanced Career Pathways Workshops are focused on connecting your education with your career aspirations and exploring your pathways to reach your goal.Mesquite Room, Student Union, 2.01.24, Main Campus
The Westside Community Center will be creating an altar or "ofrenda" as many do within San Antonio and the Westside for "Dia de los Muertos." If you would like to participate, we invite you to send in a photo of a loved one that will be placed in this space. You are welcome to join us on October 28th at 3:00 pm to set up the space and come see us at the Westside Community Center.UTSA Westside Community Center, 1310 Guadalupe St., San Antonio, TX 78207
Blueprints For Pangaea is hosting its first on-campus inventory event of the semester! Join us for a Halloween-themed afternoon where we'll inventory medical supplies while enjoying Halloween movies. By the end of the event, you will have positively impacted the health of hundreds of individuals. We require at least one hour of attendance and come dressed up because the best costumes will earn awards.Flawn Sciences Building, 3.02.02, Main Campus
Chris Villanueva and other jazz faculty will perform standards in this concert. More details to come. The Fall 2021 concert schedule is subject to change. Please continue to monitor our website and social media for updates. This concert will be live-streamed via the UTSA Music Facebook page. https://www.facebook.com/UTSAMusic When:UTSA Recital Hall, Main Campus
UTSA Sustainability will have three courses of varying difficulty to accommodate different ages and abilities. There will a one mile walk on generally level surface to introduce you to the student run community garden, a longer walk with stairs and topo changes, and a five mile bike ride to introduce you to the Leon Greenway.Tito Bradshaw Bicycle Repair Shop Ximenes Ave, Main Campus
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