(April 17, 2019) -- Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. To improve that survival rate, researchers at UTSA and the University of Texas MD Anderson Cancer Center created an online atlas to identify and classify protein signatures present at AML diagnosis.
The new protein classifications will help researchers and clinicians recommend better treatment and personalized medicine for patients suffering from this aggressive cancer, which occurs in the blood and bone marrow. The breakthrough research is published in the latest April issue of Nature Biomedical Engineering.
Researcher Amina Qutub, an associate professor in the UTSA Department of Biomedical Engineering (who joined UTSA in 2018 from Rice University), and oncologist Steven M. Kornblau, a professor and practicing clinician in the Department of Leukemia at UT MD Anderson Cancer Center, examined the genetic, epigenetic and environmental diversity that occurs in cancerous cells due to AML. Analyzing proteomic screens of 205 patient biopsies obtained at MD Anderson Cancer Center, first author Chenyue Wendy Hu (then a graduate student at the Qutub Lab, now at Uber Technologies), Kornblau and Qutub developed a new computational method called MetaGalaxy to categorize the protein signatures into 154 different patterns based on their cellular functions and pathways.
By approaching this challenge through the unique lens of developing a quantitative map for each leukemia patient from protein expression in their blood and bone marrow, rather than the standard lens of qualitative metrics and genetic risks alone, Qutub, Kornblau and their research collaborators will be able to more precisely categorize patients into risk groups and better predict their treatment outcomes.
To better understand the AML hallmarks at the proteomic (protein system) level and to share the results of their work with other researchers, the UTSA biomedical engineering professor and her team including Hu, and students Andrew Ligeralde (now at the University of California, Berkeley) and Allie Raybon (from the UTSA Department of Biomedical Engineering) built a web portal known as the Leukemia Proteome Atlas. Designed by Qutub’s and Kornblau’s teams with input from clinical collaborators worldwide, the online portal gives oncologists and cancer scientists the tools they need to investigate AML protein expression patterns from one patient to the next. It also provides investigators around the world with leads for new leukemia research and new computational tools.
Since many genetic mutations cannot be targeted, the proteomic profiling and target identification process used in this research study will accelerate the identification of therapeutic targets. It also propels researchers much closer to the development of personalized combination therapies for patients based on their unique protein signatures.
“Acute myelogenous leukemia presents as a cancer so heterogeneous that it is often described as not one, but a collection of diseases,” said Qutub. “To decipher the clues found in proteins from blood and bone marrow of leukemia patients, we developed a new computer analysis - MetaGalaxy – that identifies molecular hallmarks of leukemia. These hallmarks are analogous to the way constellations guide navigation of the stars: they provide a map to protein changes for leukemia. Our ‘hallmark’ predictions are being experimentally tested through drug screens and can be ‘programmed’ into cells through synthetic manipulation of proteins. A next step to bring this work to the clinic and impact patient care is testing whether these signatures lead to the aggressive growth or resistance to chemotherapy observed in leukemia patients. At the same time, to rapidly accelerate research in leukemia and advance the hunt for treatments, we provide the hallmarks in an online compendium where fellow researchers and oncologists worldwide can build from the resource, tools and findings, LeukemiaAtlas.org.”
Celebrate UTSA’s 50th Anniversary and share social media posts about the 50th using the hashtag #UTSA50.
The NSA Codebreaker Challenge provides students with a hands-on opportunity to develop their reverse-engineering, low-level code analysis skills while working on a realistic problem set centered around the NSA’s mission. Developer Eric Bryant will present a Tech Talk and answer questions about the challenge. Doors open at 2:30 p.m. Free pizza. Open to all.John Peace Library (JPL 4.04.22), Main Campus
UTSA's Office of Sustainability hosts a full day of activities to celebrate the opening of the Tito Bradshaw Bicycle Repair Shop. A ribbon-cutting at 6 p.m.will include President Eighmy, Mayor Nirenberg, Councilman Pelaez and Councilwoman Gonzales.Ximenes Ave. between Ximenes Ave. Lot and Brackenridge Ave. Lot 1, Main Campus
Annual symposium to highlight the importance of effective translation and interpreting in our global community.H-E-B Student Union Travis Room (HSU 2.202), Main Campus
The UTSA Institute for Law and Public Affairs and the Southwest Association of Prelaw Advisors will host the annual Law School Fair for students interested in attending law school. Attendees will have the opportunity to meet with representatives from approximately 90 ABA approved law schools (including all law schools in Texas), and learn about admissions, financing, course offerings, student life, program reputation, with the opportunity to gain application fee waivers.H-E-B Student Union, Ballroom (HSU 1.104), Main Campus
This event will showcase the new Large-Scale Testing Laboratory, built to serve students and researchers in UTSA's Department of Civil and Environmental Engineering. The Grand Opening will feature speakers, a live demonstration, and tours.Large Scale Testing Laboratory, Main Campus
To prepare, graduation candidates should attend to obtain important information about the ceremony and life after UTSA. At the event, they can order their ceremonial cap and gown and other Commencement-related items as well as win prizes and capture lasting memories with fellow Roadrunners at a selfie station. UTSA ID Card required; no reservation needed.Buena Vista Street Building, Meeting Assembly Room (BVB 1.338), Downtown Campus
To prepare, graduation candidates should attend to obtain important information about the ceremony and life after UTSA. At the event, they can order their ceremonial cap and gown and other Commencement-related items as well as win prizes and capture lasting memories with fellow Roadrunners at a selfie station. UTSA ID Card required; no reservation needed.H-E-B Student Union, Ballrooms (HSU 1.104 and 1.106), Main Campus
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.