Nov. 12, 2019 — UTSA researchers are pioneering an innovative brain study that sheds light on how the amygdala portion of the brain functions and could contribute to a better understanding of post-traumatic stress disorder, anxiety, depression and Alzheimer’s disease.
The researchers, Alfonso Apicella, an associate professor in the Department of Biology, research associate Alice Bertero, postdoctoral fellow Paul Luc Caroline Feyen, and graduate student Hector Zurita, published their study, “A non-canonical cortico-amygdala inhibitory loop,” in The Journal of Neuroscience, the flagship journal of the Society for Neuroscience. Their research was also featured on the Oct. 23 cover of the journal.
Conditions such as PTSD, anxiety and depression are thought to be linked to the abnormal functioning of the amygdala, which is located within the temporal lobes and plays a key role in processing emotions, actions and cognition.
“This novel research paper provides anatomical and physiological evidence for the existence of a long-range inhibitory pathway from the auditory cortex to the amygdala in the mouse brain,” Apicella said. “For the first time, in our paper we show this emotional pathway.”
Apicella explained that advances in the techniques for labeling individual neuronal cells made it possible to study the individual neurons extending from the auditory cortex to the amygdala.
He added that the inhibitory cortical neurons can alter the activity of the amygdala’s principal neurons and can therefore directly control the output of the amygdala. The neurons contain a substance called somatostatin, and it regulates physiological functions and forms a connection with principal neurons that project to other brain regions outside the amygdala that are involved in fear and aversive behavior.
“The discovery that the amygdala receives both excitatory and inhibitory inputs from that cortex suggests that the timing and relative strength of these inputs can affect the activity of the amygdala,” Acipella said.
Apicella and his research team noted that future experiments should examine whether this is a general mechanism by which sensory stimuli can influence the processes controlled by the amygdala, such as fear/aversive behavior and how the disruption of this pathway can lead to several neurological and psychiatric disorders, such as,Alzheimer’s, anxiety, depression and PTSD.
Research related to this topic will continue in Apicella’s lab. His research group investigates the neural basis of perception. More specifically, the researchers want to understand how cortical microcircuits process sensory information leading to behavioral outcomes.
Learn more about Alfonso Apicella’s Lab at UTSA.
Celebrate UTSA’s 50th Anniversary and share social media posts about the 50th using the hashtag #UTSA50.
UTSA Main Campus will serve as a designated polling station during the early voting period, today through October 30, and on Election Day, November 3.H-E-B Student Union Ballroom (HSU 1.104)
The First Generation and Transfer Student Center (FGTSC), Transfer and Transition Student Success Services (T2S3), and Alamo Runners invite you to join the virtual fun as we celebrate National Transfer Student Week. UTSA is enriched by transfer students who bring their diverse experiences, backgrounds, and assets to our campus. National Transfer Student Week seeks to celebrate, empower, and support transfer students with events and workshops specifically designed for transfers.Virtual Event
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Dr. Mo. Jamshidi is an Endowed chaired professor at the University of Texas-San Antonio. He is a Persian Native, born in Shiraz, Iran in 1944. He was an advisor to NASA for 10 years (including with the first MARS Mission and seven years with NASA Headquarters (Washington, DC), among other organizations. He has over 800 technical publications including 74 books in English and 5 foreign languages. For the past 20 years, he has been collecting data on Persian Scientists and Poets from 1000 BC to 2021 AD. This presentation will be about the book written by Dr. Jamshidi that collects information on Persian scientists and poets.Virtual Event
Join this informative, interactive webinar with practical tips on how to plan your charitable giving now and for the future. Michael Perkins, member of the UTSA Alumni Association and the UTSA College of Business Accounting Advisory Board, is no stranger to gift planning. As managing partner and CEO of Slattery Perkins Ramirez P.C. (“SPR”) his primary areas of focus include counseling business owners, executives, and other high net worth individuals on personal financial issues, including estate planning, wealth transfer, and income tax planning techniques. Michael also practices philanthropy himself – establishing an endowed scholarship at UTSA as well as supporting numerous charitable causes throughout San Antonio.Virtual Event
UTSA Main Campus is a voting poll for Election Day on November 3.H-E-B Student Union Ballroom (HSU 1.104
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