FEBRUARY 10, 2020 — Leaders of the newly-established San Antonio Partnership for Precision Therapeutics (SA PPT) have awarded the partnership’s first research grant. A seven-person team researching sepsis-induced organ failure will receive $200,000 in funding over two years. The award’s purpose is to advance research and breakthroughs in precision therapeutics, which is the development of drug therapies for specific populations based on genetics, lifestyle and environment.
The team, led by principal investigator Madesh Muniswamy of UT Health San Antonio, is studying the cause, prevention and treatment of multi-organ failure during sepsis. Sepsis occurs when an infection spreads to a patient’s blood or tissues causing a high risk of organ failure and death. According to the World Health Organization, an estimated 30 million people worldwide are affected by sepsis every year.
“Despite good antimicrobial therapies currently in use, some sepsis patients do not survive. Those that do survive often suffer compromised organ function and premature death,” Muniswamy said. “The goal of our research is to identify why some patients are more likely to die from sepsis and to develop a treatment that reduces organ dysfunction and damage after a sepsis diagnosis.”
The team is closely examining the mitochondrial calcium uniporter (MCU) channel that carries calcium to cells. In some sepsis patients, an overflow of calcium floods the channel, bombarding and killing healthy cells. When cells die, organs fail. The team aims to develop a drug therapy that controls the flow of calcium through the channel, allowing only necessary amounts of the element to reach cells.
The research project advances precision therapeutics by focusing on why some patients are more likely to experience MCU channel dysfunction and death. The team aims to uncover better treatment options for these patients. The long-term plan includes studying particular populations, such as Hispanic patients, who are at greater risk of sepsis complications.
“This is where precision therapeutics is key,” Muniswamy said. “Each patient is different. Some patients may require antibiotics only. Others may require combination therapies to recover. By administering multiple treatments at once, a sepsis patient may have a better chance of surviving and restoring organ function.”
The SA PPT received 12 research project submissions vying for funding. External reviewers unaffiliated with the SA PPT scored the six proposals that made it to the final round. The winning team’s proposal, Small Molecule Regulation of Mitochondrial Ca2+ Uniporter (MCU) Channel for Treatment of Multi-Organ Failure, received the top score. The presidents of the four institutions that make up the SA PPT — UTSA, Southwest Research Institute (SwRI), Texas Biomedical Research Institute (Texas Biomed), and UT Health San Antonio — made the final selection. The team includes researchers from all four institutions.
“The presidents wanted to direct funding to a research project that displayed strong collaboration among the four SA PPT institutions, as well as one that demonstrated a commitment to advancing precision therapeutics,” said Liz Tullis, SA PPT interim program director. “This team is using the knowledge and resources available at these leading institutions to address a gap in sepsis treatment. We look forward to the potentially life-saving results of their research.”
SA PPT leaders will be funding more research projects that support precision therapeutics and demonstrate collaboration among SwRI, Texas Biomed, UT Health San Antonio and UTSA researchers in 2020. For more information on the partnership, visit SAPPT.org.
The San Antonio Partnership for Precision Therapeutics was established in October 2019 to leverage the unique bioscience capabilities of four prominent San Antonio research institutions — UTSA, SwRI, TX Biomed, and UT Health San Antonio. The partnership focuses on creating breakthrough treatments tailored to specific patient populations, while serving as a model to improve health care in San Antonio, statewide and globally. The field of precision therapeutics integrates precision medicine with the drug discovery pathway, including basic research, compound development, formulation, testing, production and clinical trials leading to new FDA-approved treatments.
UTSA students, faculty, staff and community members are encouraged to raise their voices and participate in the upcoming joint primary runoff election. Any registered Bexar County voter may vote at the H-E-B Student Union Bexar Room (HSU 1.102).Bexar Room (HSU 1.102), H-E-B Student Union, Main Campus
Adult Mental Health First Aid consists of 6 hours of instructor-led training, in which teaches adults how to recognize the signs and symptoms that suggest a potential mental health challenge, how to listen nonjudgmentally and give reassurance to the individual, student/colleague, who may be experiencing a mental health challenge, and how to refer a person to appropriate professional support and services at UTSAJohn Peace Library (4.04.12C), Main Campus
Refusing to Forget is a collaborative effort to examine and expose the devastating impact of state-sanctioned racial violence throughout the early 20th century in the Texas Borderlands. This will be a two-day workshop.Gregory Luna Room, Buena Vista Building, Downtown Campus
Join fellow UTSA accounting alumni for this fun-filled event that includes breakfast, a round of golf, an awards luncheon and great prizes. All proceeds from the tournament benefit student scholarships.Canyon Springs Golf Club, 24405 Wilderness Oak, San Antonio, TX 78260
UTSA students, faculty, staff and community members are encouraged to raise their voices and participate in the upcoming joint primary runoff election. Election day is Tuesday, May 24. Any registered Bexar County voter may vote at the H-E-B Student Union Bexar Room (HSU 1.102).Bexar Room (HSU 1.102), H-E-B Student Union, Main Campus
The Faculty Coffee Chat is designed to provide faculty members the space to discuss current issues they are facing in an inclusive and supportive environment.Virtual Event
These sessions are focused on incoming Freshman who are attending the UTSA Summer Orientation and are intending to major in areas within the College of Liberal and Fine Arts! We'll have important information and giveaways for you - come meet us.Willow room (SU 2.02.1), Main Campus
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.
UTSA is a proud Hispanic Serving Institution (HSI) as designated by the U.S. Department of Education.
The University of Texas at San Antonio, a Hispanic Serving Institution situated in a global city that has been a crossroads of peoples and cultures for centuries, values diversity and inclusion in all aspects of university life. As an institution expressly founded to advance the education of Mexican Americans and other underserved communities, our university is committed to ending generations of discrimination and inequity. UTSA, a premier public research university, fosters academic excellence through a community of dialogue, discovery and innovation that embraces the uniqueness of each voice.