Latest campus and coronavirus information Roadrunner Return Fall 2020
Tuesday, October 27, 2020

Grant will help researcher explore therapy for peripheral neuropathy

Grant will help researcher explore therapy for peripheral neuropathy

SEPTEMBER 24, 2020 — The Cancer Prevention and Research Institute of Texas has awarded UTSA professor Hyoung-gon Lee $250,000. The two-year grant will fund Lee’s research, which seeks to understand the pathogenic mechanism of peripheral neuropathy and to develop a novel therapeutic approach.

“Chemotherapy-induced peripheral neuropathy is a devastating consequence of cancer treatment regimens that include neurotoxic chemotherapeutic agents such as cisplatin,” said Lee, who is an associate professor in the Department of Biology, housed in UTSA’s College of Sciences. Lee is also a member of UTSA’s Brain Health Consortium.

“CIPN is one of the most common, serious side effects that can lead to dose reductions or early discontinuation of chemotherapy, reducing the efficacy of cancer treatments and significantly impacts the quality of life of the patients due to debilitating neurological symptoms such as pain, tingling sensation, numbness and weakness.”

“Chemotherapy-induced peripheral neuropathy is a devastating consequence of cancer treatment regimens.”

Despite the high prevalence and severity of CIPN, there is currently not an effective treatment to prevent or reverse CIPN. This is mainly due to the scientific community’s limited understanding of the pathogenic mechanism of CIPN. The development of therapeutics is required to improve quality of life in cancer patients and survivors as well as enhance the therapeutic effectiveness of chemotherapy.

“Based on the previous studies, we developed a hypothesis that the induction of cell cycle activity in dorsal root ganglion sensory neurons, the main cell type affected by chemotherapeutic agents, is a key mechanism causing neurotoxicity in cisplatin-induced CIPN and thus targeting this mechanism may provide an effective therapeutic opportunity,” Lee said.

As a part of its continued commitment to cancer research in Texas, CPRIT awarded 62 new grants totaling over $114 million and consisting of 52 academic research grant awards, eight prevention awards, and two product development research awards.

Explore Hyoung-gon Lee’s research at UTSA.
Learn more about the Department of Biology and the College of Sciences.

The awards support cancer research and prevention activities taking place in universities and community organizations across Texas. To date, CPRIT has awarded $2.6 billion in grants to Texas research institutions and organizations through its academic research, prevention and product development research programs.

Lauren Moriarty

UTSA Today is produced by University Strategic Communications,
the official news source
of The University of Texas at San Antonio.

Send your feedback to

UTSA Today is produced by University Communications and Marketing, the official news source of The University of Texas at San Antonio. Send your feedback to Keep up-to-date on UTSA news by visiting UTSA Today. Connect with UTSA online at Facebook, Twitter, Youtube and Instagram.




UTSA receives national recognition for Latino enrollment, degree attainment

UTSA’s Mission

The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.

UTSA’s Vision

To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.

UTSA’s Core Values

We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.

UTSA’S Destinations

UTSA is a proud Hispanic Serving Institution (HSI) as designated by the U.S. Department of Education.

Our Commitment to Inclusivity

The University of Texas at San Antonio, a Hispanic Serving Institution situated in a global city that has been a crossroads of peoples and cultures for centuries, values diversity and inclusion in all aspects of university life. As an institution expressly founded to advance the education of Mexican Americans and other underserved communities, our university is committed to ending generations of discrimination and inequity. UTSA, a premier public research university, fosters academic excellence through a community of dialogue, discovery and innovation that embraces the uniqueness of each voice.