George Perry, Ph.D.
Areas of Specialization
» Alzheimer's disease
» Oxidative stress
Ph.D. in Marine Biology; Scripps Institution of Oceanography
B.A. in Zoology; University of California, Santa Barbara
Dr. Perry’s studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease. The lab has shown that oxidative damage is the initial cytopathology in Alzheimer disease. They are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Current studies focus on the:
- mechanism for RNA-based redox metal binding
- consequences of RNA oxidation on protein synthesis rate and fidelity
- role of redox active metals in mediating prooxidant and antioxidant properties
- signal transduction pathways altered in Alzheimer disease that allow neurons to evade apoptosis
- mechanism of phosphorylation control of oxidative damage to neurofilament proteins
Click here for a list of publications.