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Faculty

Judith A. Walmsley, Ph.D.

Professor Emeritus

Email: judith.walmsley@utsa.edu

Areas of Specialization

» Biomolecular structure
» Inorganic and bioinorganic chemistry
» Nucleotide structures


Education

Ph.D. in Chemistry; University of North Carolina
B.A. in Chemistry; Florida State University

 

Research Interests

Although I no longer have an active research laboratory, my recent research efforts have been directed at two rather different types of chemistry. One type is the synthesis and characterization of transition metal complexes containing biologically active ligands. These have included various nucleotides, proflavine, and other nitrogen-containing heterocycles. Cytotoxicity studies have shown that several Pd(II) complexes of proflavine have better activity against certain breast cancer cell lines than cis-platin (Fig. 1). Other research in this area involves the synthesis of complex multinuclear metal species formed by the use of ligands capable of bridging between metal ions. (Fig. 2).

 

A second area is an investigation of the structure of the supramolecular species formed by guanosine 5'-monophosphate in aqueous solution in the presence of Na+, K+, or Rb+. The 5'-GMP forms cyclic tetramers held together by hydrogen bonds between the guanine bases with the cations located in the central cavity of the tetramers. Stacking of the tetramers leads to very large columnar structures whose exact structures are still only partially understood. NMR and CD spectroscopy and scanning electron microscopy are used to characterize the structure.

 

Publications

Przyojski, J.A.; Myers, N.N.; Arman, H.D.; Prosvirin, A.; Dunbar, K.R.; Natarajan, M.; Krishnan, M.; Mohnan, S.; Walmsley, J.A. "Dinuclear and Heptanuclear Complexes of Copper(II) with 7-AzaindoleLligand: Synthesis, Characterization,Magnetic Properties, and Biological Activity" Journal of Inorganic Biochemistry 2013, 127, 175-181.
» abstract

Panda, M.; Walmsley, J.A. "Circular Dichroism Study of Supramolecular Assemblies of Guanosine 5’-Monophosphate" Journal of Physical Chemistry B 2011, 115, 6377-6383.
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Thomas, J.C.; Tiekink, E.R.T.; Walmsley, J.A. "[4’-(4-’Aminophenyl)-2,2’:6’,2”-terpyridine]chloridopalladium(II) chloride" Acta Cryst., Sec. E 2011, E67, m773- m774.
» abstract

Polysanskaya, T.V.; Kazhdan, I.; Motley, D.M.; Walmsley, J.A. "Synthesis, Characterization and Cytotoxicity Studies of Palladium(II)-Proflavine Complexes" Journal of Inorganic Biochemistry 2010, 104, 1205-1213.
» abstract

Hightower, J.B.; Olmos, D.R .; Walmsley, J.A. "Supramolecular Structure and Polymorphism of Alkali Metal Salts of Guanosine 5’-Monophosphate: SEM and NMR Study" Journal of Physical Chemistry B 2009, 113, 12214-12219.
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Zhu, S.; Moreno, K.X.; Jenkins, R.M.; Walmsley, J.A. "Interactions of 1,5-Naphthyridine with Pd(en)Cl2 or [Pd(en)(H2O)2](NO3)2 in Aqueous Solution" Journal of the Chemical Society, Dalton Transactions 2008, 6401-6408.
» abstract

Adrian, R.A.; Broker, G.A.; Tiekink, E.R.T.; Walmsley, J.A. "Palladium(II) Complexes of 1,10- Phenanthroline: Synthesis and X-ray Crystal Structure Determination" Inorganica Chimica Acta 2008, 361, 1261-1266.
» abstract

Walmsley, J.A.; Zhu, S.; Matilla, A.; Donowick, T.G.; Cramp. J.E.; Tercero, J.M.; Dalrymple, T. "Cyclic Tetranuclear and Hexanuclear Palladium(II) Complexes and Their Host-Guest Chemistry" Inorganic Chemistry 2007, 46, 9945-9953.
» abstract

Adrian, R.A.; Zhu, S.; Powell, D.R.; Broker, G.A.; Tiekink, E.R.T.; Walmsley, J.A. "Dinuclear Palladium(II) Complexes with Bridging Amidate Ligands" Journal of the Chemical Society, Dalton Transactions 2007, 4399-4404.
» abstract

Zhu, S., Gorski, W., Powell, D.R., Walmsley, J.A. "Synthesis, Structures, and Electrochemistry of Au(III)-ethylenediamine Complexes and Their Interaction with Guaniosine 5’-Monophosphate" Inorganic Chemistry 2006, 45, 2688-2694.
» abstract