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Carlos D. Garcia

Office Phone: (210) 458-5774
Office: BSE 1.104L
E-Mail: carlos.garcia@utsa.edu

Areas of Specialization
• Microfluidic devices and microfabrication
• Electrochemistry
• Interaction of proteins with nanomaterials

Laboratory web page



Research Interests

Microchips are one of the most promising analytical platforms due to the great advantages with respect to conventional bench-top equipment. Microfluidic devices are able to offer custom design, high throughput, sensitivity, selectivity and portability. In order to achieve a real point-of-care measurement device, simple instrumentation has to be integrated to drive the injection and separation. Electrochemical detection (ECD) methods have been widely applied for the detection of bio-compounds because they are less susceptible to decreases in signal magnitude during miniaturization and are already portable and inexpensive. For these reasons, we are very interested in studying the design, operation and biological applications of microchips and capillary electrophoresis. In addition, we are also interested in the rational design of biosensors.


Recent Publications (2013 - date)


arrow Acid-responsive nanospheres from an asparagine-derived amphiphile
Adelphe M. Mfuh, Mathew P. D. Mahindaratne, Audrey E. Yñigez-Gutierrez, Juan R. Ramos Dominguez, Jefferson T. Bedell II, Carlos D. Garcia, and George R. Negrete
RSC Advances (2015) - accepted.


arrow Importance of Protein Adsorption onto Nanomaterials for the Development of Biosensors and Analytical Devices
Samir Bhakta, Elizabeth Evans, Tomas E. Benavides, and Carlos D. Garcia
Analytica Chimica Acta (2015) - in press.


arrow Modification of Paper-Based Microfluidic Devices with Silica Nanoparticles
Elizabeth Evans, Ellen Flavia Moreira-Gabriel, Tomas E. Benavides, Wendell K. T. Coltro, and Carlos D. Garcia
Analyst 139 (2014) 5560 - 5567.


a Adsorption and Catalytic Activity of Glucose Oxidase Accumulated on OTCE upon the Application of External Potential
Tomas Benavidez, Daniel Torrente, Marcelo Marucho, and Carlos D. Garcia
Journal of Colloid & Interface Science 435 (2014) 164–170


a A Handheld Stamping Process to Fabricate Microfluidic Paper-Based Analytical Devices with Chemically Modified Surface for Clinical Assays
Paulo de T. Garcia, Thiago M. G. Cardoso, Carlos D. Garcia, E. Carrilho and Wendell K. T. Coltro
RSC Advances 4 (2014) 37637–37644


arrow Getting started with Open-Source Hardware: Development and Control of PDMS-Based Pumps for Microfluidic Devices
Eric Tavares da Costa, Maria F. Mora, Peter A. Willis, Claudimir L. do Lago, Hong Jiao, and Carlos D. Garcia
Electrophoresis 35 (2014) 2370–2377.



arrow Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving
Ellen Flavia Moreira-Gabriel, Wendell Karlos Tomazelli-Coltro, and Carlos D. Garcia
Electrophoresis 35 (2014) 2325–2332.


a Immobilization of Glucose Oxidase to Nanostructured Films of Polystyrene-block-poly(2-vinylpyridine)
Samir A Bhakta, Tomas Benavidez, and Carlos D. Garcia
Journal of Colloid & Interface Science 430 (2014) 351–356.


a Rational Selection of Substrates to Improve Color Intensity and Uniformity on Microfluidic Paper-Based Analytical Devices
Elizabeth Evans, Ellen Flavia Moreira-Gabriel, Wendell Karlos Tomazelli-Coltro, Carlos D. Garcia
Analyst 139 (2014) 2127-2132.


a Determination of Nitrite in Saliva using Microfluidic Paper-Based Analytical Devices
Samir A. Bhakta, Rubiane Borba, Mario Taba Jr, Carlos D. Garcia, and Emanuel Carrilho
Analytica Chimica Acta 809 (2014) 117-122.


a Potential-Assisted Adsorption of Bovine Serum Albumin onto Optically-Transparent Carbon Electrodes
Tomas E. Benavidez and Carlos D. Garcia
Langmuir 29 (2013) 14154–14162.


a Simultaneous Solid Phase Extraction and Derivatization of Aliphatic Primary Amines Prior to Separation and UV-Absorbance Detection
Jessica L. Felhofer, Karen Scida, Mark Penick, Peter Willis and Carlos D. Garcia
Talanta 115 (2013) 688 - 693.


a Spectroscopic and Electrochemical Characterization of Nanostructured Optically-Transparent Carbon Electrodes
Tomas E. Benavidez and Carlos D. Garcia
Electrophoresis 34 (2013) 1998 - 2006.


a Ultra-Thin Optically Transparent Carbon Electrodes Produced from Layers of Adsorbed Proteins
Sarah Alharthi, Tomas E. Benavidez and Carlos D. Garcia a
Langmuir 29 (2013) 3320 - 3327.


a Microfab-less Microfluidic Capillary Electrophoresis Devices
Thiago P. Segato, Samir A. Bhakta, Matthew Gordon, Emanuel Carrilho, Peter A. Willis, Hong Jiao, and Carlos D. Garcia
Analytical Methods 5 (2013) 1652 - 1657.


a Computational, Electrochemical, and Spectroscopic, Studies of Acetycholinesterase Covalently Attached to CNT
Murilo F. Cabral, Joseph D. Barrios, Érica M. Kataoka, Sergio A. S. Machado, Emanuel Carrilho, Carlos D. Garcia, and Arturo A. Ayon
Colloids and Surfaces B: Biointerfaces 103 (2013) 624-629.





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