Home · About the Department · Site map · Contact

Oleg Larionov
Assistant Professor

Office Phone: (210) 458-6050
Office: BSE 4.117
E-Mail: oleg.larionov@utsa.edu


Larionov Group Homepage

Areas of Specialization
• Medicinal chemistry
• Synthesis of biologically active natural products
• Enantioselective catalysis

Research Interests

The research in my group spans methodology and complex molecule synthesis. In this context, the development of novel selective and efficient reactions will be followed by their implementation in the total synthesis of biologically active natural products and analogs, with a special focus on compounds targeting cancer. In our search for new reactions we strive to develop catalytic and generally applicable processes with potential to streamline present day synthetic approaches and solve their long-standing problems.
In total synthesis we accentuate brevity, efficiency and flexibility in generation of molecular complexity.


Selected Publications




Three-component reaction of small-ring cyclic amines with arynes and acetonitrile.
Stephens, D.; Zhang, Y.; Cormier, M.; Chavez, G.; Arman, H.; Larionov, O. V.
Chem. Comm. 2013, 49, 6558–6560.





Catalytic Diastereo and Enantioselective Annualations between Transient Nitrosoalkenes and Indoles.
Zhang, Y.; Stephens, D.; Hernandez, G.; Mendoza, R.; Larionov, O. V.
Chem. Eur. J. 2012, 18, 16612–16615




An Unconventional Approach to the Enantioselective Synthesis of Caryophylloids
Larionov, O. V.; Corey, E. J.
J. Am. Chem. Soc. 2008, 130, 2954–2955




What is Amphidinolide V? Report on a Likely Conquest.
Fürstner, A.; Larionov, O.; Flügge, S.
Angew. Chem. Int. Ed. 2007, 46, 5545–5548.





Novel Inhibitor Binding Mode of Homobelactosin C to Proteasomes: New Insights into Class I MHC Ligand Generation.
Groll, M.; Larionov, O. V.; de Meijere, A.; Huber, R.
Proc. Natl. Acad. Sci. USA (PNAS) 2006, 103, 4576–4579.





Versatile Direct Synthesis of Oligosubstituted Pyrroles by Cycloaddition of alpha-Metallated Isocyanides to Acetylenes.
Larionov, O. V.; de Meijere, A.
Angew. Chem. 2005, 117, 5809–5813; Angew. Chem. Int. Ed. 2005, 44, 5664–5667.





One UTSA Circle * San Antonio, TX 78249
DOC Office (210) 458-5469 Fax (210) 458-7428