Office Phone: (210) 458-6050
Office: BSE 4.117
Larionov Group Homepage
Areas of Specialization
• Medicinal chemistry
• Synthesis of biologically active natural products
• Enantioselective catalysis
The research in my group spans methodology and complex molecule synthesis. In this context, the development of novel selective and efficient reactions will be followed by their implementation in the total synthesis of biologically active natural products and analogs, with a special focus on compounds targeting cancer. In our search for new reactions we strive to develop catalytic and generally applicable processes with potential to streamline present day synthetic approaches and solve their long-standing problems.
In total synthesis we accentuate brevity, efficiency and flexibility in generation of molecular complexity.
Three-component reaction of small-ring cyclic amines with arynes and acetonitrile.
Stephens, D.; Zhang, Y.; Cormier, M.; Chavez, G.; Arman, H.; Larionov, O. V.
Chem. Comm. 2013, 49, 6558–6560.
Catalytic Diastereo and Enantioselective Annualations between Transient Nitrosoalkenes and Indoles.
Zhang, Y.; Stephens, D.; Hernandez, G.; Mendoza, R.; Larionov, O. V.
Chem. Eur. J. 2012, 18, 16612–16615
An Unconventional Approach to the Enantioselective Synthesis of Caryophylloids
Larionov, O. V.; Corey, E. J.
J. Am. Chem. Soc. 2008, 130, 2954–2955
What is Amphidinolide V? Report on a Likely Conquest.
Fürstner, A.; Larionov, O.; Flügge, S.
Angew. Chem. Int. Ed. 2007, 46, 5545–5548.
Novel Inhibitor Binding Mode of Homobelactosin C to Proteasomes: New Insights into Class I MHC Ligand Generation.
Groll, M.; Larionov, O. V.; de Meijere, A.; Huber, R.
Proc. Natl. Acad. Sci. USA (PNAS) 2006, 103, 4576–4579.
Versatile Direct Synthesis of Oligosubstituted Pyrroles by Cycloaddition of alpha-Metallated Isocyanides to Acetylenes.
Larionov, O. V.; de Meijere, A.
Angew. Chem. 2005, 117, 5809–5813; Angew. Chem. Int. Ed. 2005, 44, 5664–5667.