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Faculty
     
 

Oleg Larionov
Assistant Professor

Office Phone: (210) 458-6050
Office: BSE 4.117
E-Mail: oleg.larionov@utsa.edu

 

Larionov Group Homepage




Areas of Specialization
• Medicinal chemistry
• Synthesis of biologically active natural products
• Enantioselective catalysis





Research Interests

The research in my group spans methodology and complex molecule synthesis. In this context, the development of novel selective and efficient reactions will be followed by their implementation in the total synthesis of biologically active natural products and analogs, with a special focus on compounds targeting cancer. In our search for new reactions we strive to develop catalytic and generally applicable processes with potential to streamline present day synthetic approaches and solve their long-standing problems.
In total synthesis we accentuate brevity, efficiency and flexibility in generation of molecular complexity.







 



Selected Publications

 

 

 

Three-component reasction of small-ring cyclic amines with arynes and acetonitrile.
Stephens, D.; Zhang, Y.; Cormier, M.; Chavez, G.; Arman, H.; Larionov, O. V.
Chem. Comm. 2013, 49, 6558–6560.

 

 

 

 

Catalytic Diastereo-and Enantioselective Annualations between Transient Nitrosoalkenes and Indoles.
Zhang, Y.; Stephens, D.; Hernandez, G.; Mendoza, R.; Larionov, O. V.
Chem. Eur. J. 2012, 18, 16612–16615

 

 


 

An Unconventional Approach to the Enantioselective Synthesis of Caryophylloids
Larionov, O. V.; Corey, E. J.
J. Am. Chem. Soc. 2008, 130, 2954–2955

 

 


 

What is Amphidinolide V? Report on a Likely Conquest.
Fürstner, A.; Larionov, O.; Flügge, S.
Angew. Chem. Int. Ed. 2007, 46, 5545–5548.


 

 

 

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Novel Inhibitor Binding Mode of Homobelactosin C to Proteasomes: New Insights into Class I MHC Ligand Generation.
Groll, M.; Larionov, O. V.; de Meijere, A.; Huber, R.
Proc. Natl. Acad. Sci. USA (PNAS) 2006, 103, 4576–4579.

 

 

 

 

Versatile Direct Synthesis of Oligosubstituted Pyrroles by Cycloaddition of alpha-Metallated Isocyanides to Acetylenes.
Larionov, O. V.; de Meijere, A.
Angew. Chem. 2005, 117, 5809–5813; Angew. Chem. Int. Ed. 2005, 44, 5664–5667.

 

 

 

 

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