Office: BSE 4.117
Office Phone: (210) 458-6050
Larionov Group Homepage: http://larionovgroup.com
Areas of Specialization
• Medicinal chemistry
• Synthesis of biologically active natural products
• Enantioselective catalysis
The research in my group spans methodology and complex molecule synthesis. In this context, the development of novel selective and efficient reactions will be followed by their implementation in the total synthesis of biologically active natural products and analogs, with a special focus on compounds targeting cancer. In our search for new reactions we strive to develop catalytic and generally applicable processes with potential to streamline present day synthetic approaches and solve their long-standing problems. In total synthesis we accentuate brevity, efficiency and flexibility in generation of molecular complexity.
Stephens, D.E.; Lakey-Beitia, J.; Atesin, A.C.; Atesin, T.A.; Chavez, G.; Arman, H.D.; Larionov, O.V. Palladium-Catalyzed C8-Selective C–H Arylation of Quinoline N-Oxides: Insights into the Electronic, Steric and Solvation Effects on the Site-Selectivity by Mechanistic and DFT Computational Studies. ACS Catal. 2014, DOI: 10.1021/cs501813v.
Stephens, D.E.; Chavez, G.; Valdes, M.; Dovalina, M.; Arman, H.D.; Larionov, O.V. Synthetic and Mechanistic Aspects of the Regioselective Base-Mediated Reaction of Perfluoroalkyl- and Perfluoroarylsilanes with Heterocyclic N-Oxides. Org. Biomol. Chem. 2014, 12, 6190-6199.
Stephens, D.E.; Larionov, O.V. Straightforward Access to Hexahydropyrrolo[2,3-b]indole Core by a Regioselective C3-Azo Coupling Reaction of Arenediazonium Compounds with Tryptamines. Eur. J. Org. Chem. 2014, 3662–3670.
Jia, Y.; Larionov, O.; Jarrett, H.W.J. Coupling of deoxyribonucleic acid to solid supports using 3' terminal ribose incorporation. Chromatogr. A 2014, 1339, 73–79.
Larionov, O.V.; Stephens, D.; Chavez, G.; Mfuh, A.; Hadi, A.; Naumova, A.; Skenderi, B. Insights into the Mechanistic and Synthetic Aspects of the Mo/P-Catalyzed Oxidation of N-Heterocycles. Org. Biomol. Chem. 2014, 12, 3026–3036.
Larionov, O.V.; Stephens, D.; Mfuh, A.; Chavez, G. Direct, Catalytic, and Regioselective Synthesis of 2-Alkyl-, Aryl-, and Alkenyl-Substituted N-Heterocycles from N-Oxides. Org. Lett. 2014, 16, 864–867.
Stephens, D.; Zhang, Y.; Cormier, M.; Chavez, G.; Arman, H.; Larionov, O.V. Three-component reaction of small-ring cyclic amines with arynes and acetonitrile. Chem. Comm. 2013, 49, 6558–6560.
Zhang, Y.; Stephens, D.; Hernandez, G.; Mendoza, R.; Larionov, O.V. Catalytic Diastereo and Enantioselective Annualations between Transient Nitrosoalkenes and Indoles. Chem. Eur. J. 2012, 18, 16612–16615.
Larionov, O.V.; Corey, E.J. An Unconventional Approach to the Enantioselective Synthesis of Caryophylloids. J. Am. Chem. Soc. 2008, 130, 2954–2955.
Fürstner, A.; Larionov, O.; Flügge, S. What is Amphidinolide V? Report on a Likely Conquest. Angew. Chem. Int. Ed. 2007, 46, 5545–5548.
Groll, M.; Larionov, O.V.; de Meijere, A.; Huber, R. Novel Inhibitor Binding Mode of Homobelactosin C to Proteasomes: New Insights into Class I MHC Ligand Generation. Proc. Natl. Acad. Sci. USA (PNAS) 2006, 103, 4576–4579.
Larionov, O.V.; de Meijere, A. Versatile Direct Synthesis of Oligosubstituted Pyrroles by Cycloaddition of α-Metallated Isocyanides to Acetylenes. Angew. Chem. 2005, 117, 5809–5813; Angew. Chem. Int. Ed. 2005, 44, 5664–5667.