Judith A. Walmsley
Areas of Specialization
• Biomolecular Structure
• Inorganic and Bioinorganic Chemistry
• Nucleotide Structures
My research has been directed at two rather different types of chemistry. One type is the synthesis and characterization of transition metal complexes containing biologically active ligands. These have included various nucleotides, proflavine, and other nitrogen-containing heterocycles. Cytotoxicity studies have shown that several Pd(II) complexes of proflavine have better activity against certain breast cancer cell lines than cis-platin (Fig. 1). Other research in this area involves the synthesis of complex multinuclear metal species formed by the use of ligands capable of bridging between metal ions. (Fig. 2).
A second area is an investigation of the structure of the supramolecular species formed by guanosine 5’-monophosphate in aqueous solution in the presence of Na+, K+, or Rb+. The 5’-GMP forms cyclic tetramers held together by hydrogen bonds between the guanine bases with the cations located in the central cavity of the tetramers. Stacking of the tetramers leads to very large columnar structures whose exact structures are still only partially understood. NMR and CD spectroscopy and scanning electron microscopy are used to characterize the structures
Fig 1.Two possible structures for the DMSO solution of polymeric [Pd(proflavine)Cl2] as modeled with Spartan.
Fig. 2. View of the dication complex in 2 showing the disk geometry of the ion and the nearly planar arrangement of the Cu. Hydrogen atoms have been omitted for clarity.
Color code: C, gray; Cu, green; N, blue; O, red.
“Dinuclear and Heptanuclear Complexes of Copper(II) with 7-Azaindole Ligand: Synthesis, Characterization, Magnetic Properties and Biological Activity”.
Journal of Inorganic Biochemistry 2013, 127, 175-181
Przyojski, J. A.; Myers, N. N.; Arman, H. D.; Prosvirin, A.; Dunbar, K. R.; Natarajan, M.; Krishman, M.; Mohan, S. Walmsley, J. A.
”Circular Dichroism Study of Supramolecular Assemblies of Guanosine 5’-Monophosphate”.
Panda, M.; Walmsley, J. A.
Journal of Physical Chemistry, B 2011, 115, 6377-6383.
“Synthesis, Characterization and Cytotoxicity Studies of Palladium(II)-Proflavine Complexes".
Polyanskaya, T. V.; Kashdan, I.; Motley, D. M.; Walmsley, J. A.
Journal of Inorganic Biochemistry 2010, 104, 1205-1213.
"Supramolecular Structure and Polymorphism of Alkali Metal Salts of Guanosine 5-Monophosphate: SEM and NMR Study”.
Hightower, J. B.; Olmos, D. R .; Walmsley, J. A.
Journal of Physical Chemistry, B 2009, 113, 12214-12219.
“Crystal and Molecular Structure of Dichloro(ethylenediamine)gold(III) Nitrate: [Au(NH2CH2CH2NH2)Cl2]NO3.
Motley, D. M.; Walmsley, J. A.; Zukerman-Schpector, J.; Tiekink, E. R. T.
IJournal of Chemical Crystallography, 2009,39, 364-367.
“Interactions of 1,5-Naphthyridine with Pd(en)Cl2 or [Pd(en)(H2O)2](NO3)2 in Aqueous Solution”.
Zhu, S.; Moreno, K. X.; Jenkins, R. M.; Walmsley, J. A
Journal of the Chemical Society, Dalton Transactions 2008, 6401-6408.
“Palladium(II) Complexes of 1,10- Phenanthroline: Synthesis and X-ray Crystal Structure Determination”.
Adrian, R. A.; Broker, G. A.; Tiekink, E. R. T.; Walmsley, J. A.
Inorganica Chimica Acta, 2008, 361, 1261-1266.
“Cyclic Tetranuclear and Hexanuclear Palladium(II) Complexes and Their Host-Guest Chemistry”.
Walmsley, J. A.; Zhu, S.; Matilla, A.; Donowick, T. G.; Cramp. J. E.; Tercero, J. M.; Dalrymple, T.
Inorganic Chemistry 2007, 46, 9945-9953.
“Dinuclear Palladium(II) Complexes with Bridging Amidate Ligands”.
Adrian, R. A.; Zhu, S.; Powell, D. R.; Broker, G. A.; Tiekink, E. R. T.; Walmsley, J. A.
Journal of the Chemical Society, Dalton Transactions 2007, 4399-4404.
”Synthesis and X-ray Crystal Structure Determination of Monomeric cis-Pd(2,2’-bipyridine)(NO3)2”.
Adrian, R. A.; Zhu, S.; Klausmeyer, K. K.; Walmsley, J. A.
Inorganic Chemistry Communications, 2007, 10, 1527-1530.
"Synthesis, Structures, and Electrochemistry of Au(III)-ethylenediamine Complexes and Their Interaction with Guaniosine 5’- Monophosphate”.
Zhu, S., Gorski, W., Powell, D. R., Walmsley, J. A.
Inorganic Chemistry, 2006, 45, 2688-2694.